{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:02:15Z","timestamp":1793026935831,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T00:00:00Z","timestamp":1528934400000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006150","name":"Office of Policy and International Affairs","doi-asserted-by":"publisher","award":["R01 AG 042437"],"award-info":[{"award-number":["R01 AG 042437"]}],"id":[{"id":"10.13039\/100006150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006150","name":"Office of Policy and International Affairs","doi-asserted-by":"publisher","award":["P50 AG05136"],"award-info":[{"award-number":["P50 AG05136"]}],"id":[{"id":"10.13039\/100006150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006150","name":"Office of Policy and International Affairs","doi-asserted-by":"publisher","award":["R01 AG029672"],"award-info":[{"award-number":["R01 AG029672"]}],"id":[{"id":"10.13039\/100006150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>There may be biologically relevant heterogeneity within typical late\u2010onset Alzheimer's dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed cognitive data from people with incident late\u2010onset Alzheimer's dementia from a prospective cohort study. We determined individual averages across memory, visuospatial functioning, language, and executive functioning. We identified domains with substantial impairments relative to that average. We compared demographic, neuropathology, and genetic findings across groups defined by relative impairments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 32,286 person\u2010years of follow\u2010up, 869 people developed Alzheimer's dementia. There were 393 (48%) with no domain with substantial relative impairments. Some participants had isolated relative impairments in memory (148, 18%), visuospatial functioning (117, 14%), language (71, 9%), and executive functioning (66, 8%). The group with isolated relative memory impairments had higher proportions with \u2265 <jats:italic>APOE<\/jats:italic> \u03b54 allele, more extensive Alzheimer's\u2010related neuropathology, and higher proportions with other Alzheimer's dementia genetic risk variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>A cognitive subgrouping strategy may identify biologically distinct subsets of people with Alzheimer's dementia.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2017.04.011","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T11:15:39Z","timestamp":1497611739000},"page":"1307-1316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Incidence of cognitively defined late\u2010onset Alzheimer's dementia subgroups from a prospective cohort study"],"prefix":"10.1002","volume":"13","author":[{"given":"Paul K.","family":"Crane","sequence":"first","affiliation":[{"name":"Department of Medicine University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Trittschuh","sequence":"additional","affiliation":[{"name":"VA Puget Sound Health Care System Geriatric Research Education and Clinical Center  Seattle WA USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhabrata","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Saykin","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Sciences and the Indiana Alzheimer's Disease Center Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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