{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:06:39Z","timestamp":1790154399932,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T00:00:00Z","timestamp":1499817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 NS048005"],"award-info":[{"award-number":["T32 NS048005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001157","name":"Harvard NeuroDiscovery Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001157","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007299","name":"Harvard Catalyst","doi-asserted-by":"publisher","award":["UL1 TR001102"],"award-info":[{"award-number":["UL1 TR001102"]}],"id":[{"id":"10.13039\/100007299","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To examine the risk of Alzheimer's disease (AD) among cancer survivors in a national database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort of 3,499,378 mostly male US veterans aged \u226565 years were followed between 1996 and 2011. We used Cox models to estimate risk of AD and alternative outcomes (non\u2010AD dementia, osteoarthritis, stroke, and macular degeneration) in veterans with and without a history of cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Survivors of a wide variety of cancers had modestly lower AD risk, but increased risk of the alternative outcomes. Survivors of screened cancers, including prostate cancer, had a slightly increased AD risk. Cancer treatment was independently associated with decreased AD risk; those who received chemotherapy had a lower risk than those who did not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Survivors of some cancers have a lower risk of AD but not other age\u2010related conditions, arguing that lower AD diagnosis is not simply due to bias. Cancer treatment may be associated with decreased risk of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2017.04.012","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T05:05:41Z","timestamp":1499922341000},"page":"1364-1370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Association of cancer and Alzheimer's disease risk in a national cohort of veterans"],"prefix":"10.1002","volume":"13","author":[{"given":"Laura","family":"Frain","sequence":"first","affiliation":[{"name":"Division of Aging Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Swanson","sequence":"additional","affiliation":[{"name":"Oslo Centre for Biostatistics and Epidemiology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Aging Brigham and Women's Hospital  Boston MA USA"},{"name":"Massachusetts Veterans Epidemiology and Resource Information Center (MAVERIC), VA Boston Healthcare System (VABHS)  Jamaica Plain MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Massachusetts Veterans Epidemiology and Resource Information Center (MAVERIC), VA Boston Healthcare System (VABHS)  Jamaica Plain MA USA"},{"name":"Boston University School of Public Health  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun Ping","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Beth Israel Deaconess Medical Center  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Betensky","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T.H. Chan School of Public Health  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Driver","sequence":"additional","affiliation":[{"name":"Division of Aging Brigham and Women's Hospital  Boston MA USA"},{"name":"Massachusetts Veterans Epidemiology and Resource Information Center (MAVERIC), VA Boston Healthcare System (VABHS)  Jamaica Plain MA USA"},{"name":"Geriatric Research Education and Clinical Center, VABHS  Jamaica Plain MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9497-6"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000356498"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e1442"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829c5ec1"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000341411"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152889.94785.51"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c91873"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720509788486608"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2011.11.007"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3464"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004173"},{"key":"e_1_2_8_13_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000355899","article-title":"Alzheimer's disease and cancer: current epidemiological evidence for a mutual protection","volume":"42","author":"Catala\u2010Lopez F","year":"2014","journal-title":"Neuroepidemiology"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000086"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm286"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00423"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182941990"},{"key":"e_1_2_8_18_2","doi-asserted-by":"crossref","unstructured":"HAHanson KPHorn KMRasmussen JMHoffman KRSmith.Is cancer protective for subsequent Alzheimer's disease risk? 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