{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:49:35Z","timestamp":1793393375274,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004785","name":"NordForsk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["311492"],"award-info":[{"award-number":["311492"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003128","name":"Ty\u00f6suojelurahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Higher midlife body mass index (BMI) is suggested to increase the risk of dementia, but weight loss during the preclinical dementia phase may mask such effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined this hypothesis in 1,349,857 dementia\u2010free participants from 39 cohort studies. BMI was assessed at baseline. Dementia was ascertained at follow\u2010up using linkage to electronic health records (N\u00a0=\u00a06894). We assumed BMI is little affected by preclinical dementia\u00a0when assessed decades before dementia onset and much affected when assessed nearer diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Hazard ratios per 5\u2010kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      increase in BMI for dementia were 0.71 (95% confidence interval\u00a0=\u00a00.66\u20130.77), 0.94 (0.89\u20130.99), and 1.16 (1.05\u20131.27) when BMI was assessed 10\u00a0years, 10\u201020\u00a0years, and &gt;20\u00a0years before dementia diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The association between BMI and dementia is likely to be attributable to two different processes: a harmful effect of higher BMI, which is observable in long follow\u2010up, and a reverse\u2010causation effect that makes a higher BMI to appear protective when the follow\u2010up is short.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2017.09.016","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T01:30:15Z","timestamp":1511314215000},"page":"601-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":428,"title":["Body mass index and risk of dementia: Analysis of individual\u2010level data from 1.3 million individuals"],"prefix":"10.1002","volume":"14","author":[{"given":"Mika","family":"Kivim\u00e4ki","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Public Health University College London  London UK"},{"name":"Clinicum, Department of Public Health, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Finnish Institute of Occupational Health  Helsinki and Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritva","family":"Luukkonen","sequence":"additional","affiliation":[{"name":"Clinicum, Department of Public Health, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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