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Pathology began in the young\u2010adult entorhinal cortex with protein kinase A\u2010phosphorylation of tau, progressing to fibrillation with paired helical filaments and mature tangles in oldest animals. Tau pathology in the dorsolateral prefrontal cortex paralleled but lagged behind the entorhinal cortex, not afflicting the primary visual cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The aging rhesus macaque provides the long\u2010sought animal model for exploring the etiology of late\u2010onset Alzheimer's disease and for testing preventive strategies.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2017.11.005","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T09:26:54Z","timestamp":1512984414000},"page":"680-691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["The aged rhesus macaque manifests Braak stage III\/IV Alzheimer's\u2010like pathology"],"prefix":"10.1002","volume":"14","author":[{"given":"Constantinos D.","family":"Paspalas","sequence":"first","affiliation":[{"name":"Department of Neuroscience Yale School of Medicine  New Haven 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