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On the other hand, the rs4837766 variant, which is among the best cis\u2010expression quantitative trait loci in the <jats:italic>CDK5RAP2<\/jats:italic> gene, is associated with lower mild cognitive impairment\/AD risk and conversion rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The rs10984186 risk and rs4837766 protective polymorphic variants of the <jats:italic>CDK5RAP2<\/jats:italic> gene might act as potent genetic modifiers for AD risk and\/or conversion by modulating the expression of this gene.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2017.12.004","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T04:57:53Z","timestamp":1516337873000},"page":"787-796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<i>CDK5RAP2<\/i> gene and tau pathophysiology in late\u2010onset sporadic Alzheimer's 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