{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:08:41Z","timestamp":1790708921220,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Diagnostic relevance of plasma amyloid \u03b2 (A\u03b2) for Alzheimer's disease (AD) process yields conflicting results. The objective of the study was to assess plasma levels of A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      and A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      in amnestic mild cognitive impairment (MCI), nonamnestic MCI, and AD patients and to investigate relationships between peripheral and central biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One thousand forty participants (417 amnestic MCI, 122 nonamnestic MCI, and 501 AD) from the Biomarker of AmyLo\u00efd pepTide and AlZheimer's diseAse Risk multicenter prospective study with cognition, plasma, cerebrospinal fluid (CSF), and magnetic resonance imaging assessments were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma A\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      and A\u03b2\n                      <jats:sub>1\u201340<\/jats:sub>\n                      were lower in AD (36.9 [11.7] and 263 [80] pg\/mL) than in amnestic MCI (38.2 [11.9] and 269 [68] pg\/mL) than in nonamnestic MCI (39.7 [10.5] and 272 [52] pg\/mL), respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01 for overall difference between groups for A\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04 for A\u03b2\n                      <jats:sub>1\u201340<\/jats:sub>\n                      ). Globally, plasma A\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      correlated with age, Mini\u2013Mental State Examination, and\n                      <jats:italic>APOE<\/jats:italic>\n                      \u00a0\u03b54 allele. Plasma A\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      correlated with all CSF biomarkers in MCI but only with CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      in AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Plasma A\u03b2 was associated with cognitive status and CSF biomarkers, suggesting the interest of plasma amyloid biomarkers for diagnosis purpose.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2018.01.004","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T12:46:43Z","timestamp":1518871603000},"page":"858-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Plasma amyloid levels within the Alzheimer's process and correlations with central 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