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Understanding within\u2010person biomarker(s) change over time is critical for trial enrollment and design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Longitudinal cerebrospinal fluid samples from the Alzheimer's Disease Neuroimaging Initiative were assayed for novel markers of neuronal\/synaptic injury (visinin\u2010like protein 1, Ng, and SNAP\u201025) and neuroinflammation (YKL\u201040) and compared with \u03b2 amyloid 42, tau, and phospho\u2010tau181. General linear mixed models were used to compare within\u2010person rates of change in three clinical groups (cognitively normal, mild cognitive impairment, and Alzheimer's disease) further defined by \u03b2 amyloid status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Levels of injury markers were highly positively correlated. Despite elevated baseline levels as a function of clinical status and amyloid\u2010positivity, within\u2010person decreases in these measures were observed in the early symptomatic, amyloid\u2010positive Alzheimer's disease group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Knowledge of within\u2010person biomarker change will impact interpretation of biomarker outcomes in clinical trials that are dependent on disease stage.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2018.01.012","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T18:27:15Z","timestamp":1521829635000},"page":"869-879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":146,"title":["Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer's disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Courtney 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