{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:47:45Z","timestamp":1792234065823,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The \u03b54 allele of the apolipoprotein E (<jats:italic>APOE<\/jats:italic>) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of <jats:italic>APOE<\/jats:italic> polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The \u03b54 allele was associated with reduced longevity as \u03b54 versus \u03b53 homozygotes lived on average 2.6\u00a0years shorter (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). In AD, \u03b54 carriers lived 1.0\u00a0years shorter than noncarriers (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.028). The \u03b54 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The <jats:italic>APOE<\/jats:italic> \u03b54 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2018.02.003","type":"journal-article","created":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T12:09:16Z","timestamp":1520942956000},"page":"895-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Apolipoprotein E genotypes and longevity across dementia disorders"],"prefix":"10.1002","volume":"14","author":[{"given":"Tobias","family":"Skillb\u00e4ck","sequence":"first","affiliation":[{"name":"Department of Neurochemistry Institute of Neuroscience and Physiology The 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