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The recent identification of reduced <jats:italic>APOE<\/jats:italic> DNA methylation in AD postmortem brains prompted this study to investigate <jats:italic>APOE<\/jats:italic> methylation in LBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genomic DNA from postmortem brain tissues (frontal lobe and cerebellum) of neuropathological pure (np) controls and npAD, LBD\u00a0+\u00a0AD, and npLBD subjects were bisulfite pyrosequenced. DNA methylation levels of two <jats:italic>APOE<\/jats:italic> subregions were then compared for these groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>APOE<\/jats:italic> DNA methylation was significantly reduced in npLBD compared with np controls, and methylation levels were lowest in the LBD\u00a0+\u00a0AD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Given that npLBD and npAD postmortem brains shared a similar reduction in <jats:italic>APOE<\/jats:italic> methylation, it is possible that an aberrant epigenetic change in <jats:italic>APOE<\/jats:italic> is linked to risk for both diseases.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2018.02.005","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T17:47:11Z","timestamp":1521395231000},"page":"889-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["<i>APOE<\/i> DNA methylation is altered in Lewy body dementia"],"prefix":"10.1002","volume":"14","author":[{"given":"Jessica","family":"Tulloch","sequence":"first","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center VA Puget Sound Health Care System Seattle WA USA"},{"name":"Division of Gerontology and Geriatric Medicine Department of Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Leong","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine Department of Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine Department of Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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