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Generalized estimating equation models were used to assess <jats:italic>APOE<\/jats:italic> \u03b54 prevalence in relation to age, sex, education, and geographical location.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>APOE<\/jats:italic> \u03b54 prevalence was 66% in AD\u2010type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in A\u03b2+ cognitively normal and A\u03b2+ mild cognitive impairment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) but not in A\u03b2+ AD dementia (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.66). The prevalence was highest in Northern Europe but did not vary by sex or education.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The <jats:italic>APOE<\/jats:italic> \u03b54 prevalence in AD was higher than that in previous studies, which did not require presence of A\u03b2 pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2018.02.009","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T06:23:03Z","timestamp":1522218183000},"page":"913-924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":84,"title":["Prevalence of the apolipoprotein E \u03b54 allele in amyloid \u03b2 positive subjects across the spectrum of Alzheimer's disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Niklas","family":"Mattsson","sequence":"first","affiliation":[{"name":"Clinical Memory Research Unit Clinical Sciences Malm\u00f6 Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Groot","sequence":"additional","affiliation":[{"name":"Department of Neurology and Alzheimer Center VU University Medical Center Neuroscience Campus 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