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The ability to image\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      the pathological substrates of degenerative diseases and visualize their downstream impact has led to improved models of pathogenesis, better differential diagnosis of atypical conditions, as well as focused subject selection and monitoring of treatment in clinical trials aimed at delaying or preventing the symptomatic phase of Alzheimer's disease. In this article, we present the main molecular imaging techniques used in research and practice. We further summarize the key findings brought about by each technique individually and more recently, as adjuncts to each other. Specific limitations of each imaging modality are discussed, as well as recommendations to overcome them. A nonvalidated clinical algorithm is proposed for earlier and more accurate identification of complex\/atypical neurodegenerative diseases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2018.06.2855","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T10:09:47Z","timestamp":1531908587000},"page":"1522-1552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Molecular imaging in dementia: Past, present, and future"],"prefix":"10.1002","volume":"14","author":[{"suffix":"Jr.","given":"Robert","family":"Laforce","sequence":"first","affiliation":[{"name":"Clinique Interdisciplinaire de M\u00e9moire CHU de Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Soucy","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre Montreal Neurological Institute McGill 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