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Previous studies reported a trend toward increased cerebrospinal fluid (CSF) \u03b1\u2010synuclein (\u03b1\u2010syn) concentrations in AD compared with other neurodegenerative diseases and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The pathophysiological role of CSF \u03b1\u2010syn in asymptomatic subjects at risk of AD has not been explored. We performed a large\u2010scale cross\u2010sectional observational monocentric study of preclinical individuals at risk for AD (INSIGHT\u2010preAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a positive association between CSF \u03b1\u2010syn concentrations and brain \u03b2\u2010amyloid deposition measures as mean cortical standard uptake value ratios. We demonstrate positive correlations between CSF \u03b1\u2010syn and both CSF t\u2010tau and p\u2010tau<jats:sub>181<\/jats:sub> concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Animal models presented evidence, indicating that \u03b1\u2010syn may synergistically and directly induce fibrillization of both tau and \u03b2\u2010amyloid. Our data indicate an association of CSF \u03b1\u2010syn with AD\u2010related pathophysiological mechanisms, during the preclinical phase of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2018.06.3053","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:05:05Z","timestamp":1532563505000},"page":"1623-1631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Association of cerebrospinal fluid \u03b1\u2010synuclein with total and phospho\u2010tau<sub>181<\/sub> protein concentrations and brain amyloid load in cognitively normal subjective memory complainers stratified by Alzheimer's disease biomarkers"],"prefix":"10.1002","volume":"14","author":[{"given":"Andrea","family":"Vergallo","sequence":"first","affiliation":[{"name":"AXA Research Fund &amp; Sorbonne University Chair Paris France"},{"name":"Sorbonne University GRC n\u00b0 21 Alzheimer Precision Medicine (APM) AP\u2010HP Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Boulevard de l'h\u00f4pital Paris France"},{"name":"Brain &amp; Spine Institute (ICM) INSERM U 1127 CNRS UMR 7225 Boulevard de l'h\u00f4pital Paris France"},{"name":"Institute of Memory and Alzheimer's Disease (IM2A) Department of Neurology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital AP\u2010HP Boulevard de l'h\u00f4pital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9\u2010Sosata","family":"Bun","sequence":"additional","affiliation":[{"name":"AXA Research Fund &amp; Sorbonne University Chair Paris France"},{"name":"Sorbonne University GRC n\u00b0 21 Alzheimer Precision Medicine (APM) AP\u2010HP Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Boulevard de l'h\u00f4pital Paris France"},{"name":"Brain &amp; Spine Institute (ICM) INSERM U 1127 CNRS UMR 7225 Boulevard de l'h\u00f4pital Paris France"},{"name":"Institute of Memory and Alzheimer's Disease (IM2A) Department of Neurology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital AP\u2010HP Boulevard de l'h\u00f4pital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Toschi","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention University of Rome \u201cTor Vergata\u201d Rome Italy"},{"name":"Department of Radiology \u201cAthinoula A. 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