{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:31:54Z","timestamp":1792859514995,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T00:00:00Z","timestamp":1536883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The objective of this study was to examine the prevalence of the coexistence of parkinsonism in patients with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Outpatients were evaluated with Mini\u2013Mental State Examination, Clinical Dementia Rating Scale, NIA\u2010AA criteria, MRI, and\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010IMP SPECT (3D\u2010SSP). Parkinsonism in patients diagnosed with MCI (Mini\u2013Mental State Examination \u226524, n\u00a0=\u00a063) or mild AD (Mini\u2013Mental State Examination 20\u201323, n\u00a0=\u00a043) was examined using the Unified Parkinson's Disease Rating Scale\u2013III and\n                      <jats:sup>123<\/jats:sup>\n                      I\u2010FP\u2010CIT dopamine transporter SPECT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred six patients (60\u201397\u00a0years) were enrolled. Fifty\u2010six patients (52.8%) were diagnosed as having concomitant parkinsonism with rigidity and resting tremor and dopamine transporter reduction in the basal ganglia. The mean (SD) age (n\u00a0=\u00a056) was 80.6 (6.1) years, significantly older than patients without parkinsonism [77.6 (7.0) years, n\u00a0=\u00a050] (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). The mean (SD) UPDRS\u2013III score was 5.8 (2.4).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence rate of the coexistence of mild parkinsonism in MCI or mild AD may be higher than previously recognized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2018.06.3054","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T08:45:51Z","timestamp":1536914751000},"page":"1615-1622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["High prevalence of parkinsonism in patients with MCI or mild Alzheimer's disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Shoichi","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Neurology Agano City Hospital Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520420071025"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.12.2300"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550200033007"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199601020-00008"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.61.7.944"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.196"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.8.1114"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000138440.39918.0C"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1986.00520070020010"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240110"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000158423.05224.7F"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00269.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2935"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"e_1_2_5_18_2","first-page":"153","volume-title":"Recent Developments in Parkinson's Disease","author":"Fahn S.","year":"1987"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601113340202"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21433"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.12.1503"},{"key":"e_1_2_5_22_2","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1212\/01.WNL.0000156157.97411.5E","article-title":"Association between mild parkinsonian signs and mild cognitive impairment in a community","volume":"12","author":"Louis E.D.","year":"2005","journal-title":"Neurology"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000188878.81385.73"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2184"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/089198879300600306"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.8.1298"},{"key":"e_1_2_5_27_2","first-page":"555","volume-title":"Neurodegenerative diseases","author":"Rajput A.H.","year":"1994"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.11.1739"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.3_Part_1.500"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb09766.x"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70471-9"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu035"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.6.1150"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.5.1346"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.6.1583"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131289"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410312"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370306"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90341-0"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199005000-00003"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1526-9"}],"container-title":["Alzheimer's &amp; 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