{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:21:25Z","timestamp":1790256085626,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005224","name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Little is known about effects of physical activity (PA) in genetically driven early\u2010onset autosomal dominant Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross\u2010sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD\u2010like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1\u00a0years later compared with low exercisers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2018.06.3059","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T05:14:54Z","timestamp":1537852494000},"page":"1427-1437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease"],"prefix":"10.1002","volume":"14","author":[{"given":"Stephan","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Section for Dementia Research Department of Cellular Neurology Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Preische","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid R.","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"Centre of Excellence for Alzheimer's Disease Research and Care School of Medical and Health Sciences Edith Cowan University Perth Australia"},{"name":"Department of Biomedical Sciences Macquarie 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Salloway","sequence":"additional","affiliation":[{"name":"Department of Neurology The Warren Alpert Medical School of Brown University Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjie","family":"Xiong","sequence":"additional","affiliation":[{"name":"Division of Biostatistics The Knight Alzheimer's Disease Research Center Washington University School of Medicine St Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie","family":"Benzinger","sequence":"additional","affiliation":[{"name":"Department of Neurology Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Buckles","sequence":"additional","affiliation":[{"name":"Department of Neurology Knight Alzheimer's Disease Research Center 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