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We hypothesize that multimodal interventions that address many risk factors simultaneously and are individually tailored to patients may help reduce AD risk. We describe a novel clinical methodology used to evaluate and treat patients at two Alzheimer's Prevention Clinics. The framework applies evidence\u2010based principles of clinical precision medicine to tailor individualized recommendations, follow patients longitudinally to continually refine the interventions, and evaluate N\u2010of\u20101 effectiveness (trial registered at ClinicalTrials.gov NCT03687710). Prior preliminary results suggest that the clinical practice of AD risk reduction is feasible, with measurable improvements in cognition and biomarkers of AD risk. We propose using these early findings as a foundation to evaluate the comparative effectiveness of personalized risk management within an international network of clinician researchers in a cohort study possibly leading to a randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2018.08.004","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T04:31:18Z","timestamp":1542083478000},"page":"1663-1673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["The clinical practice of risk reduction for Alzheimer's disease: A precision medicine approach"],"prefix":"10.1002","volume":"14","author":[{"given":"Richard S.","family":"Isaacson","sequence":"first","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine and NewYork\u2010Presbyterian New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Ganzer","sequence":"additional","affiliation":[{"name":"School of Nursing Hunter College City University of New York New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hollie","family":"Hristov","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine and NewYork\u2010Presbyterian New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hackett","sequence":"additional","affiliation":[{"name":"Department of Psychology Temple University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Caesar","sequence":"additional","affiliation":[{"name":"Loyola School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Crystal Run Healthcare Middletown NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kachko","sequence":"additional","affiliation":[{"name":"Inner Source Health New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Mel\u00e9ndez\u2010Cabrero","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine San Juan PR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneela","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine and NewYork\u2010Presbyterian New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Scheyer","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine and NewYork\u2010Presbyterian New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu Ji","family":"Hwang","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine\u2010Qatar Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Berkowitz","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Hendrix","sequence":"additional","affiliation":[{"name":"Biostatistics Pentara Corporation Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Mureb","sequence":"additional","affiliation":[{"name":"Department of Neurology Weill Cornell Medicine and NewYork\u2010Presbyterian New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Schelke","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University College of Physicians &amp; 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