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Excluding \u03b52\/\u03b54 carriers, multivariable regressions for each CVD\u2010related neuropathology compared \u03b54 and \u03b52 carriers to \u03b53\/\u03b53 carriers adjusting for confounders including age and Alzheimer's neuropathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred forty\u2010two individuals (24.7%; \u223c87.7\u00a0years at death; 39.9% nondemented) were \u03b53\/\u03b54 or \u03b54\/\u03b54, and 180 (13.0%; \u223c89.9\u00a0years at death; 66.6% nondemented) were \u03b52\/\u03b53 or \u03b52\/\u03b52. \u03b54 carriers had higher odds of macroinfarcts (odds ratio\u00a0=\u00a01.41, 95% confidence interval: 1.02\u20131.94, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03), whereas \u03b52 carriers had higher odds of moderate\u2010to\u2010severe arteriolosclerosis (odds ratio\u00a0=\u00a01.68, 95% confidence interval: 1.15\u20132.45, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006) compared to \u03b53\/\u03b53 carriers. Age\u2010stratified analyses suggested that these relationships were driven by \u03b54 carriers &lt;90\u00a0years at death and \u03b52 carriers \u226590\u00a0years at death, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p><jats:italic>APOE<\/jats:italic> differentially affects type and timing of CVD\u2010related neuropathology.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2018.08.007","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T16:53:09Z","timestamp":1539363189000},"page":"258-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["<i>APOE<\/i> genotypes as a risk factor for age\u2010dependent accumulation of cerebrovascular disease in older adults"],"prefix":"10.1002","volume":"15","author":[{"given":"Melissa","family":"Lamar","sequence":"first","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center 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