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We leveraged the National Alzheimer's Coordinating Center to examine the association between self\u2010reported TBI with loss of consciousness and AD neuropathologic changes, and with baseline and longitudinal clinical status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The sample included 4761 autopsy participants (453 with remote TBI with loss of consciousness; 2822 with AD neuropathologic changes) from National Alzheimer's Coordinating Center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Self\u2010reported TBI did not predict AD neuropathologic changes (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u00a0.10). Reported TBI was not associated with baseline or change in dementia severity or cognitive function in participants with or without autopsy\u2010confirmed AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Self\u2010reported TBI with loss of consciousness may not be an independent risk factor for clinical or pathological AD. Research that evaluates number and severity of TBIs is needed to clarify the neuropathological links between TBI and dementia documented in other large clinical databases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2018.12.015","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T23:31:36Z","timestamp":1551915096000},"page":"686-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Failure to detect an association between self\u2010reported traumatic brain injury and Alzheimer's disease neuropathology and dementia"],"prefix":"10.1002","volume":"15","author":[{"given":"Michael A.","family":"Sugarman","sequence":"first","affiliation":[{"name":"Boston University Alzheimer's Disease Center and CTE Center Boston University School of Medicine Boston MA USA"},{"name":"Edith Nourse Rogers Memorial Veterans Hospital Department of Neuropsychology Bedford MA 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