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CSF SNAP\u201025, VILIP\u20101, and YKL\u201040 were altered very early in the AD time course, approximately 15\u201319\u00a0years before estimated symptom onset. All CSF biomarkers predicted important AD\u2010related outcomes including performance on a cognitive composite, brain amyloid burden as measured by amyloid positron emission tomography, and the estimated years from symptom onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Early abnormalities in CSF tTau, pTau, SNAP\u201025, VILIP\u20101, and YKL\u201040 suggest that synaptic damage, neuronal injury, and neuroinflammation begin shortly after the commencement of brain amyloid accumulation.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2018.12.019","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T16:40:49Z","timestamp":1551717649000},"page":"655-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease"],"prefix":"10.1002","volume":"15","author":[{"given":"Suzanne 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