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Assessments included global cognitive function and executive function (primary outcomes) and brain functional connectivity and structural changes (secondary outcomes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty patients were randomized across three medical centers in Beijing. At the end of the intervention, the cognitive training group showed significant improvement in Montreal Cognitive Assessment relative to the active control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.013) and significantly increased functional connectivity between the left dorsolateral prefrontal cortex and medial prefrontal cortex, which was significantly correlated with Montreal Cognitive Assessment change (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2019.01.009","type":"journal-article","created":{"date-parts":[[2019,3,17]],"date-time":"2019-03-17T16:40:43Z","timestamp":1552840843000},"page":"605-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["The effects of 7\u2010week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog\u2010VACCINE study): A randomized controlled trial"],"prefix":"10.1002","volume":"15","author":[{"given":"Yi","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Innovation Center for Neurological Disorders Xuanwu Hospital Capital Medical University Beijing China"},{"name":"Key Laboratory of Neurodegenerative Diseases Ministry of Education of the People's Republic of China Beijing 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