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On the other hand, high sU is associated with increased cardiovascular risk which might increase the risk of dementia, especially for vascular dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 1968\u20131969, a population\u2010based sample of 1462 women aged 38 to 60\u00a0years was examined and were followed up over 44\u00a0years (mean 33.1\u00a0years). We examined whether sU (determined in 1968\u20131969 and 1992\u20131994) is associated with risk of late\u2010life dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 44 years of follow\u2010up, a higher sU (per standard deviation of 76.5\u00a0\u03bcmol\/L) was associated with lower risk for dementia (n\u00a0=\u00a0320; hazard ratio [HR] 0.81; confidence interval [CI] 0.72\u20130.91), Alzheimer's disease (n\u00a0=\u00a0152; HR 0.78; CI 0.66\u20130.91), and vascular dementia (n\u00a0=\u00a052; HR 0.66; CI 0.47\u20130.94).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings support the hypothesis that sU has a protective role in the development of dementia, regardless of dementia subtype. This may have important implications in the treatment of dementia and treatment goals for hyperuricemia in patients with gout.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2019.01.014","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T07:52:55Z","timestamp":1556783575000},"page":"754-763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Urate and risk of Alzheimer's disease and vascular dementia: A population\u2010based study"],"prefix":"10.1002","volume":"15","author":[{"given":"Lieke E.J.M.","family":"Scheepers","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Inflammation Research Institute of Medicine The Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart T.H.","family":"Jacobsson","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and 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