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Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n\u00a0=\u00a0242), had mild cognitive impairment (n\u00a0=\u00a0236), or had AD\u2010type dementia (n\u00a0=\u00a0115). Logistic regressions were carried out between plasma metabolites (n\u00a0=\u00a0883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight metabolites were associated with amyloid \u03b2 and one with t\u2010tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>PFAMs have been found increased and associated with amyloid \u03b2 burden in CSF and clinical measures.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2019.03.004","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T19:41:24Z","timestamp":1557344484000},"page":"817-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort"],"prefix":"10.1002","volume":"15","author":[{"given":"Min","family":"Kim","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Science King's College London London UK"},{"name":"Steno 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