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There were no cross\u2010sectional differences, however, apolipoprotein E \u03b54 (<jats:italic>APOE<\/jats:italic>\u00a0\u03b54) carriers demonstrated slower increase in FC in frontal lobes. There was no impact of individual brain amyloid load status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>For the first time, we demonstrated that the pleiotropic biological effect of the <jats:italic>APOE<\/jats:italic> \u03b54 allele impacts the dynamic trajectory of the DMN during aging. Dynamic functional biomarkers may\u00a0become useful surrogate outcomes for the development of preclinical targeted therapeutic interventions.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2019.03.006","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T07:31:47Z","timestamp":1558164707000},"page":"940-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease"],"prefix":"10.1002","volume":"15","author":[{"given":"Patrizia A.","family":"Chiesa","sequence":"first","affiliation":[{"name":"Sorbonne University, GRC no 21 Alzheimer Precision Medicine (APM), AP\u2010HP Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Boulevard de l'h\u00f4pital Paris France"},{"name":"Brain &amp; Spine Institute (ICM), INSERM U 1127, CNRS UMR 7225 Boulevard de l'h\u00f4pital Paris 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