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Association of cognitive (logical memory, clinical dementia rating, cognitive complaint severity, and Mini\u2013Mental State Examination) and motoric factors (gait velocity) with dementia risk was computed using Cox models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 156 incident dementias (134 Alzheimer's disease). In the pooled sample, logical memory (adjusted hazard ratio [aHR] 0.91), cognitive complaint severity (aHR 1.53), and Mini\u2013Mental State Examination (aHR 0.75) predicted transition of MCR to dementia. Clinical dementia rating score \u22650.5 predicted dementia (aHR 3.18) in one cohort. Gait velocity did not predict dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>While MCR is a motoric\u2010based predementia syndrome, severity of cognitive but not motoric impairments predicts conversion to dementia.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2019.03.011","type":"journal-article","created":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T07:32:19Z","timestamp":1559374339000},"page":"870-877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Motoric cognitive risk syndrome and predictors of transition to dementia: A multicenter study"],"prefix":"10.1002","volume":"15","author":[{"given":"Joe","family":"Verghese","sequence":"first","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine Bronx NY USA"},{"name":"Department of Medicine Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Neurology Rush Alzheimer's Disease Center Rush University Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine Bronx NY USA"},{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mindy J.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmeline","family":"Ayers","sequence":"additional","affiliation":[{"name":"Department of Neurology Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000717"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls191"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150154"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.1.121"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5332-y"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00580.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.106914"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-179939"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322573"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.02962.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12633"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1001090"},{"key":"e_1_2_6_14_2","volume-title":"WMS\u2010R: Wechsler memory scale\u2010revised: manual","author":"Wechsler D","year":"1984"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000096129"},{"key":"e_1_2_6_17_2","volume-title":"Applications of Item Response Theory to Practical Testing Problems","author":"FM L","year":"1980"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.2.198"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.2.262"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv126"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.5.713"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293396"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.1974"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.05.005"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70678-0"},{"key":"e_1_2_6_26_2","article-title":"A gray matter volume covariance network associated with the motoric cognitive risk syndrome: a multi\u2010cohort MRI study","author":"Blumen HM","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-018-9871-7"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv092"}],"container-title":["Alzheimer's &amp; 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