{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:50:19Z","timestamp":1772121019322,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG045390"],"award-info":[{"award-number":["AG045390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001167","name":"Larry L. 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Familial frontotemporal lobar degeneration offers a unique opportunity to develop predictors of symptom onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We created dementia risk scores in 268 familial frontotemporal lobar degeneration family members by entering covariate\u2010adjusted standardized estimates of brain atrophy into a logistic regression to classify asymptomatic versus demented participants. The score's predictive value was tested in a separate group who were followed up longitudinally (stable vs. converted to dementia) using Cox proportional regressions with dementia risk score as the predictor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cross\u2010validated logistic regression achieved good separation of asymptomatic versus demented (accuracy\u00a0=\u00a090%, SE\u00a0=\u00a00.06). Atrophy scores predicted conversion from asymptomatic or mildly\/questionably symptomatic to dementia (HR\u00a0=\u00a01.51, 95% CI: [1.16,1.98]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Individualized quantification of baseline brain atrophy is a promising predictor of progression in asymptomatic familial frontotemporal lobar degeneration mutation carriers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2019.04.007","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T17:00:27Z","timestamp":1562000427000},"page":"37-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration"],"prefix":"10.1002","volume":"16","author":[{"given":"Adam 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