{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T19:04:06Z","timestamp":1770491046915,"version":"3.49.0"},"reference-count":70,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01AG054700"],"award-info":[{"award-number":["K01AG054700"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We classified individuals based on their baseline performance on cognitive measures and investigated the association between cognitive classifications and neuropathological findings \u223c7 years later, as an external validator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Brain autopsies of 779 decedents were examined. Baseline latent class analysis on 10 neuropsychological measures was previously assigned: mixed\u2010domains impairment (n = 39, 5%), memory\u2010specific impairment (n = 210, 27%), frontal impairment (n = 113, 14.5%), average cognition (n = 360, 46.2%), and superior cognition (n = 57, 7.3%). Linear regressions and risks ratios were used to examine the relation of latent class assignment at enrollment with neuropathological indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amyloid \u03b2, tau, and transactive response DNA\u2010binding protein 43 were associated with mixed\u2010domains impairment and memory\u2010specific impairment classes \u223c7 years before death. Moderate arteriolosclerosis was associated with membership in the frontal impairment class.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings support the use of latent class models that incorporate more comprehensive neuropsychological measures to classify cognitive impairment.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2019.05.012","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T17:15:10Z","timestamp":1565716510000},"page":"1195-1207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neuropsychological latent classes at enrollment and postmortem neuropathology"],"prefix":"10.1002","volume":"15","author":[{"given":"Andrea R.","family":"Zammit","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B.","family":"Hall","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ezzati","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mindy J.","family":"Katz","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Muniz\u2010Terrera","sequence":"additional","affiliation":[{"name":"University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m09989"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-179939"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4668"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140276"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.57.102904.190024"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-008-9054-1"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21706"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322618"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219668.47116.e6"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003326"},{"key":"e_1_2_8_12_2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3233\/JAD-132147","article-title":"Neuropsychological syndromes associated with Alzheimer's\/vascular dementia: a latent class analysis","volume":"42","author":"Libon D.J.","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.04.451"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199812000-00009"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f39adc"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10161"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.3.370"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.5.758"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200205000-00014"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25123"},{"key":"e_1_2_8_21_2","first-page":"804","article-title":"Varied effects of age\u2010related neuropathologies on the trajectory of late life cognitive decline","volume":"140","author":"Boyle P.A.","year":"2017","journal-title":"Brain"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2012.740001"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180604"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180737"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471721182"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511499531.004"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10940-010-9113-7"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713002225"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2016.10.011"},{"key":"e_1_2_8_30_2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S0954579403000105","article-title":"Developmental trajectories of boys' delinquent group membership and facilitation of violent behaviors during adolescence","volume":"15","author":"Lacourse E.","year":"2003","journal-title":"Dev Psychopathol"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.39.2.222"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agy074"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322663"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.2307\/271063"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01246098"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/pan\/mph001"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-013-0385-x"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1080\/10705511.2014.915181"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/pan\/mpq025"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/10705511.2013.742377"},{"key":"e_1_2_8_41_2","article-title":"Robustness of stepwise latent class modeling with continuous distal outcomes","volume":"23","author":"Bakk Z.","year":"2015","journal-title":"Struct Equ Modeling"},{"key":"e_1_2_8_42_2","volume-title":"Wechsler Memory Scale \u2010 Revised","author":"Wechsler D.","year":"1987"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688638408401233"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.9.1159"},{"key":"e_1_2_8_45_2","volume-title":"The Boston Naming Test","author":"Kaplan E.F.","year":"1983"},{"key":"e_1_2_8_46_2","volume-title":"Adult Intelligence Scale\u2010III","author":"Wechsler D.","year":"1997"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/17.6.547"},{"key":"e_1_2_8_48_2","unstructured":"Raven J Raven JC Court JH. Manual for Raven's progressive matrices and vocabulary scales. Oxford: Oxford Psychologists Press; 1998."},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500300038006"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2005.07.003"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24388"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003610"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12365"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.595082"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000042478.08543.F7"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002175"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.623462"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000150886.50187.30"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000055863.87435.B2"},{"key":"e_1_2_8_60_2","unstructured":"Muth\u00e9n LK Muth\u00e9n BO. Mplus User's Guide: Statistical Analysis with Latent Variables (7th ed.). Los Angeles CA: Muth\u00e9n & Muth\u00e9n; 1998\u20102016."},{"key":"e_1_2_8_61_2","volume-title":"SPSS Inc. IBM SPSS Statistics for Windows","year":"2016"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.14.2.295"},{"key":"e_1_2_8_63_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jns.2004.11.029","article-title":"Understanding the pathology of vascular cognitive impairment","volume":"229","author":"Jellinger K.A.","year":"2005","journal-title":"J Neurol Sci"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1017\/S135561771700100X"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.241"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152982.47274.9E"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.3.378"},{"key":"e_1_2_8_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00135-0"},{"key":"e_1_2_8_69_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510370056032"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70191-6"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.4103\/2229-3485.179436"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526019301530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1552526019301530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.jalz.2019.05.012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.jalz.2019.05.012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T19:21:42Z","timestamp":1759864902000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1016\/j.jalz.2019.05.012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,13]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1016\/j.jalz.2019.05.012"],"URL":"https:\/\/doi.org\/10.1016\/j.jalz.2019.05.012","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,13]]},"assertion":[{"value":"2019-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}