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Most such biomarker studies are targeted to specific proteins or are biased toward high abundant proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>4001 plasma proteins were measured in two groups of participants (discovery group\u00a0=\u00a0516, replication group\u00a0=\u00a0365) selected from the European Medical Information Framework for Alzheimer's disease Multimodal Biomarker Discovery study, all of whom had measures of amyloid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A panel of proteins (n\u00a0=\u00a044), along with age and apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54, predicted brain amyloid deposition with good performance in both the discovery group (area under the curve\u00a0=\u00a00.78) and the replication group (area under the curve\u00a0=\u00a00.68). Furthermore, a causal relationship between amyloid and tau was confirmed by Mendelian randomization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The results suggest that high\u2010dimensional plasma protein testing could be a useful and reproducible approach for measuring brain amyloid deposition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2019.06.4951","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T17:55:37Z","timestamp":1567706137000},"page":"1478-1488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan 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