{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:27:19Z","timestamp":1787761639319,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001961","name":"AXA Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001961","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Successful development of effective \u03b2\u2010site amyloid precursor protein cleaving enzyme 1 (BACE1)\u2013targeted therapies for early stages of Alzheimer's disease requires biomarker\u2010guided intervention strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated whether key biological factors such as sex, apolipoprotein E (<jats:italic>APOE \u03b54<\/jats:italic>) allele, and age affect longitudinal plasma BACE1 concentrations in a large monocenter cohort of individuals at risk for Alzheimer's disease. We explored the relationship between plasma BACE1 concentrations and levels of brain amyloid\u2010\u03b2 (A\u03b2) deposition, using positron emission tomography global standard uptake value ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline and longitudinal mean concentrations of plasma BACE1 were significantly higher in women than men. We also found a positive significant impact of plasma BACE1 on baseline A\u03b2\u2013positron emission tomography global standard uptake value ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our results suggest a sexual dimorphism in BACE1\u2010related upstream mechanisms of brain A\u03b2 production and deposition. We argue that plasma BACE1 should be considered in further biomarker validation and qualification studies as well as in BACE1 clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2019.07.001","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T05:03:30Z","timestamp":1571115810000},"page":"1274-1285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Brain A\u03b2 load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD"],"prefix":"10.1002","volume":"15","author":[{"given":"Andrea","family":"Vergallo","sequence":"first","affiliation":[{"name":"Sorbonne University, GRC n\u00b0 21, Alzheimer Precision Medicine (APM), AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Boulevard de l'h\u00f4pital Paris France"},{"name":"Brain and Spine Institute (ICM), INSERM U 1127, CNRS UMR 7225, Boulevard de 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