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Whether Gd accumulates in brains of individuals with an age\u2010dependent BBB breakdown and\/or mild cognitive impairment remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed T1\u2010weighted magnetic resonance imaging (MRI) scans from 52 older participants with BBB breakdown in the hippocampus 19\u201028 months after either cyclic or linear Gd agent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no change in T1\u2010weighted signal intensity between the baseline contrast MRI and unenhanced MRI on re\u2010examination in any of the studied 10 brain regions with either Gd agent suggesting undetectable Gd brain retention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Gd does not accumulate in brains of older individuals with a BBB breakdown in the hippocampus. Thus, Gd agents can be used without risk of brain retention within a \u223c2\u2010year follow\u2010up to study BBB in the aging human brain in relation to cognition and\/or other pathologies.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2019.07.012","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T03:02:22Z","timestamp":1576551742000},"page":"1568-1575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Undetectable gadolinium brain retention in individuals with an age\u2010dependent blood\u2010brain barrier breakdown in the hippocampus and mild cognitive impairment"],"prefix":"10.1002","volume":"15","author":[{"given":"Axel","family":"Montagne","sequence":"first","affiliation":[{"name":"Zilkha Neurogenetic Institute Department of Physiology and Neuroscience Keck School of Medicine University of Southern California Los Angeles CA 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