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We aimed to investigate the ability of A\u03b2 misfolding in blood plasma, <jats:italic>APOE4<\/jats:italic> status, and dementia risk factors to predict diagnosis of AD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Within a community\u2010based cohort, A\u03b2 misfolding in plasma measured by immuno\u2010infrared sensor and <jats:italic>APOE<\/jats:italic> genotype were determined at baseline in 770 participants followed over 14\u00a0years. Associations between A\u03b2 misfolding, <jats:italic>APOE4<\/jats:italic>, and other predictors with clinical AD, vascular dementia, and mixed dementia diagnoses were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A\u03b2 misfolding was associated with a 23\u2010fold increased odds of clinical AD diagnosis within 14\u00a0years. No association was observed with vascular dementia\/mixed dementia diagnoses. <jats:italic>APOE4<\/jats:italic>\u2010positive participants had a 2.4\u2010fold increased odds of clinical AD diagnosis within 14\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>A\u03b2 misfolding in blood plasma was a strong, specific risk prediction marker for clinical AD even many years before diagnosis in a community\u2010based setting.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2019.08.189","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T08:00:59Z","timestamp":1570780859000},"page":"283-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Prediction of Alzheimer's disease diagnosis within 14\u00a0years through A\u03b2 misfolding in blood plasma compared to <i>APOE4<\/i> status, and other risk 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