{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:48:31Z","timestamp":1786686511664,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Innovative Medicines Initiative Joint Undertaking","award":["115568"],"award-info":[{"award-number":["115568"]}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Synaptic damage, axonal neurodegeneration, and neuroinflammation are common features in Alzheimer's disease (AD), frontotemporal dementia (FTD), and Creutzfeldt\u2010Jakob disease (CJD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Unicentric cohort of 353 participants included healthy control (HC) subjects, AD continuum stages, genetic AD and FTD, and FTD and CJD. We measured cerebrospinal fluid neurofilament light (NF\u2010L), neurogranin (Ng), 14\u20103\u20103, and YKL\u201040 proteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biomarkers showed differences in HC subjects versus AD, FTD, and CJD. Disease groups differed between them except AD versus FTD for YKL\u201040. Only NF\u2010L differed between all stages within the AD continuum. AD and FTD symptomatic mutation carriers presented differences with respect to HC subjects. Applying the AT(N) system, 96% subjects were positive for neurodegeneration if 14\u20103\u20103 was used, 94% if NF\u2010L was used, 62% if Ng was used, and 53% if YKL\u201040 was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Biomarkers of synapse and neurodegeneration differentiate HC subjects from neurodegenerative dementias and between AD, FTD, and CJD. NF\u2010L and 14\u20103\u20103 performed similar to total tau when AT(N) system was applied.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.jalz.2019.09.001","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T18:29:45Z","timestamp":1571941785000},"page":"262-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias"],"prefix":"10.1002","volume":"16","author":[{"given":"Anna","family":"Antonell","sequence":"first","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit Hospital Cl\u00ednic Fundaci\u00f3 Cl\u00ednic per a la Recerca Biom\u00e8dica Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona  Barcelona 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