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Trophic factor was elevated in both AD groups and associated with cognition and gray matter volumes. Degenerative factor was elevated in EOAD, with higher levels associated with worse functioning in this group. Biomarkers of inflammation were not significantly different between groups and were only associated with age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Disucssion<\/jats:title>\n                    <jats:p>\n                      Plasma proteomic biomarkers provide novel means of investigating molecular processes\n                      <jats:italic>in\u00a0vivo<\/jats:italic>\n                      and their contributions to clinical outcomes. We present initial investigations of several of these fluid biomarkers, capturing aspects of astrocytopathy, neuronal injury, cellular plasticity, and inflammation in EOAD versus LOAD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2019.09.004","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T23:29:35Z","timestamp":1577143775000},"page":"681-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":231,"title":["Plasma biomarkers of astrocytic and neuronal dysfunction in early\u2010 and late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"16","author":[{"given":"Fanny M.","family":"Elahi","sequence":"first","affiliation":[{"name":"Department of Neurology Memory and Aging Center University of California, San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin 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