{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:55:48Z","timestamp":1792522548296,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["1R01MH106577"],"award-info":[{"award-number":["1R01MH106577"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Preventing dementia, or modifying disease course, requires identification of presymptomatic or minimally symptomatic high\u2010risk individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used longitudinal electronic health records from two large academic medical centers and applied a validated natural language processing tool to estimate cognitive symptomatology. We used survival analysis to examine the association of cognitive symptoms with incident dementia diagnosis during up to 8\u00a0years of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 267,855 hospitalized patients with 1,251,858 patient years of follow\u2010up data, 6516 (2.4%) received a new diagnosis of dementia. In competing risk regression, an increasing cognitive symptom score was associated with earlier dementia diagnosis (HR 1.63; 1.54\u20131.72). Similar results were observed in the second hospital system and in subgroup analysis of younger and older patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>A cognitive symptom measure identified in discharge notes facilitated stratification of risk for dementia up to 8\u00a0years before diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2019.09.084","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T03:02:43Z","timestamp":1576551763000},"page":"531-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Stratifying risk for dementia onset using large\u2010scale electronic health record data: A retrospective cohort study"],"prefix":"10.1002","volume":"16","author":[{"suffix":"Jr.","given":"Thomas H.","family":"McCoy","sequence":"first","affiliation":[{"name":"Center for Quantitative Health, Massachusetts General Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Harvard T.H. Chan School of Public Health  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia M.","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Center for Quantitative Health, Massachusetts General Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolph E.","family":"Tanzi","sequence":"additional","affiliation":[{"name":"Genetics and Aging Research Unit McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease Department of Neurology Massachusetts General Hospital  Charlestown MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Berretta","sequence":"additional","affiliation":[{"name":"Translational Neuroscience Lab. 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