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whether alcohol consumption, alcohol dependence, or Alcohol Use Disorder Identification Test (AUDIT) scores were causally associated with the risk of Late\u2010Onset Alzheimer's disease (LOAD) or Alzheimer's disease age of onset survival (AAOS). Additionally, \u03b3\u2010glutamyltransferase levels were included as a positive control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no evidence of a causal association between alcohol consumption, alcohol dependence, or AUDIT, and LOAD. Alcohol consumption was associated with an earlier AAOS and increased \u03b3\u2010glutamyltransferase blood concentrations. Alcohol dependence was associated with a delayed AAOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>MR found robust evidence of a causal association between alcohol consumption and an earlier AAOS, but not alcohol intake and LOAD risk. The protective effect of alcohol dependence is potentially due to survivor bias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.jalz.2019.09.086","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T10:20:16Z","timestamp":1574850016000},"page":"345-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study"],"prefix":"10.1002","volume":"16","author":[{"given":"Shea J.","family":"Andrews","sequence":"first","affiliation":[{"name":"Ronald M. Loeb Center for Alzheimer's disease Department of Neuroscience Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Goate","sequence":"additional","affiliation":[{"name":"Ronald M. 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