{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:30:18Z","timestamp":1761514218652},"reference-count":44,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","jamda.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Medical Directors Association"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jamda.2018.04.017","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T11:55:38Z","timestamp":1528458938000},"page":"936-941","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Safety of Direct Oral Anticoagulants and Vitamin K Antagonists in Oldest Old Patients: A Prospective Study"],"prefix":"10.1016","volume":"19","author":[{"given":"Carlos","family":"Rodr\u00edguez-Pascual","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivett","family":"Torres-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"G\u00f3mez-Quintanilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Isabel","family":"Ferrero-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagdish","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Guiti\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carmen","family":"Basalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Montero-Magan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Vilches-Moraga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Teresa","family":"Olcoz-Chiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Paredes-Gal\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Rodr\u00edguez-Artalejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jamda.2018.04.017_bib1","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: The AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study","volume":"285","author":"Go","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jamda.2018.04.017_bib2","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1161\/01.CIR.0000140263.20897.42","article-title":"Lifetime risk for development of atrial fibrillation: The Framingham Heart Study","volume":"110","author":"Lloyd-Jones","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jamda.2018.04.017_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1161\/CIRCULATIONAHA.105.595140","article-title":"Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence","volume":"114","author":"Miyasaka","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jamda.2018.04.017_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2147\/CLEP.S47385","article-title":"Epidemiology of atrial fibrillation: European perspective","volume":"6","author":"Zoni-Berisso","year":"2014","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.jamda.2018.04.017_bib5","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: The Framingham study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"10.1016\/j.jamda.2018.04.017_bib6","first-page":"e28","article-title":"American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics\u20142014 update: A report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jamda.2018.04.017_bib7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/eurheartj\/ehs314","article-title":"The CHA2DS2-VASc score identifies those patients with atrial fibrillation and a CHADS2 score of 1 who are unlikely to benefit from oral anticoagulant therapy","volume":"34","author":"Coppens","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jamda.2018.04.017_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1161\/STROKEAHA.114.007199","article-title":"Stroke and major bleeding risk in elderly patients aged >75 years with atrial fibrillation: The Loire Valley atrial fibrillation project","volume":"46","author":"Lip","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.jamda.2018.04.017_bib9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.7326\/0003-4819-151-5-200909010-00003","article-title":"The net clinical benefit of warfarin anticoagulation in atrial fibrillation","volume":"151","author":"Singer","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jamda.2018.04.017_bib10","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1161\/CIRCULATIONAHA.111.055079","article-title":"Net clinical benefit of warfarin in patients with atrial fibrillation: A report from the Swedish Atrial Fibrillation Cohort Study","volume":"125","author":"Friberg","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jamda.2018.04.017_bib11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.7326\/0003-4819-146-12-200706190-00007","article-title":"Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation","volume":"146","author":"Hart","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jamda.2018.04.017_bib12","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1001\/archinte.1993.00410130073007","article-title":"Bleeding complications in oral anticoagulant therapy. An analysis of risk factors","volume":"153","author":"Van der Meer","year":"1993","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jamda.2018.04.017_bib13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2165\/00002512-199914040-00005","article-title":"Safety of treatment with oral anticoagulants in the elderly. A systematic review","volume":"14","author":"Hutten","year":"1999","journal-title":"Drugs Aging"},{"key":"10.1016\/j.jamda.2018.04.017_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jamacardio.2015.0345","article-title":"Incidence and determinants of traumatic intracranial bleeding among older veterans receiving warfarin for atrial fibrillation","volume":"1","author":"Dodson","year":"2016","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jamda.2018.04.017_bib15","doi-asserted-by":"crossref","first-page":"927","DOI":"10.7326\/0003-4819-131-12-199912210-00004","article-title":"Warfarin use among ambulatory patients with nonvalvular atrial fibrillation: The AnTicoagulation and Risk factors In Atrial fibrillation (ATRIA) study","volume":"131","author":"Go","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jamda.2018.04.017_bib16","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/01.STR.0000209239.71702.ce","article-title":"Translating the results of randomized trials into clinical practice: the challenge of warfarin candidacy among hospitalized elderly patients with atrial fibrillation","volume":"37","author":"Hylek","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.jamda.2018.04.017_bib17","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1093\/eurheartj\/ehl015","article-title":"Euro Heart Survey Investigators. Antithrombotic treatment in real-life atrial fibrillation patients: a report from the Euro Heart Survey on Atrial Fibrillation","volume":"27","author":"Nieuwlaat","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jamda.2018.04.017_bib18","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1161\/CIRCULATIONAHA.110.004747","article-title":"Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the Randomized Evaluation of Long-term anticoagulant therapY (RE-LY) trial","volume":"123","author":"Eikelboom","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jamda.2018.04.017_bib19","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCULATIONAHA.113.005008","volume":"130","author":"Halperin","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jamda.2018.04.017_bib20","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1093\/eurheartj\/ehu046","article-title":"Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial","volume":"35","author":"Halvorsen","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jamda.2018.04.017_bib21","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1136\/heartjnl-2016-310358","article-title":"Effects of dabigatran according to age in atrial fibrillation","volume":"103","author":"Lauw","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.jamda.2018.04.017_bib22","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1253\/circj.CJ-13-0465","article-title":"Stroke prevention with oral anticoagulation therapy in patients with atrial fibrillation\u2014focus on the elderly","volume":"77","author":"Lip","year":"2013","journal-title":"Circ J"},{"key":"10.1016\/j.jamda.2018.04.017_bib23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.beha.2013.07.011","article-title":"New oral anticoagulants in elderly patients","volume":"26","author":"Barco","year":"2013","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1016\/j.jamda.2018.04.017_bib24","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1161\/CIRCULATIONAHA.114.013267","article-title":"Efficacy and harms of direct oral anticoagulants in the elderly for stroke prevention in atrial fibrillation and secondary prevention of venous thromboembolism: Systematic review and meta-analysis","volume":"132","author":"Sharma","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jamda.2018.04.017_bib25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/CIRCOUTCOMES.115.002369","article-title":"Dabigatran versus warfarin for atrial fibrillation in real-world clinical practice: A systematic review and meta-analysis","volume":"9","author":"Romanelli","year":"2016","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.jamda.2018.04.017_bib26","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1055\/s-0035-1550158","article-title":"Direct oral anticoagulants in frail older adults: A geriatric perspective","volume":"41","author":"Ho","year":"2015","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jamda.2018.04.017_bib27","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A\u00a0new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J\u00a0Chronic Dis"},{"key":"10.1016\/j.jamda.2018.04.017_bib28","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/geront\/10.1_Part_1.20","article-title":"Progress in the development of the index of ADL","volume":"10","author":"Katz","year":"1970","journal-title":"Gerontologist"},{"key":"10.1016\/j.jamda.2018.04.017_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: Self-maintaining and instrumental activities of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"key":"10.1016\/j.jamda.2018.04.017_bib30","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1176\/ajp.139.9.1136","article-title":"The global deterioration scale for assessment of primary degenerative dementia","volume":"139","author":"Reisberg","year":"1982","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jamda.2018.04.017_bib31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7326\/0003-4819-145-4-200608150-00004","article-title":"Chronic kidney disease epidemiology collaboration. Using standardized serum creatinine values in the Modification of Diet in Renal Disease study equation for estimating glomerular filtration rate","volume":"145","author":"Levey","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jamda.2018.04.017_bib32","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1001\/jama.285.22.2864","article-title":"Validation of clinical classification schemes for predicting stroke: Results from the National Registry of Atrial Fibrillation","volume":"285","author":"Gage","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jamda.2018.04.017_bib33","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1378\/chest.09-1584","article-title":"Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: The Euro Heart Survey on Atrial Fibrillation","volume":"137","author":"Lip","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.jamda.2018.04.017_bib34","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1378\/chest.10-0134","article-title":"A\u00a0novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: The Euro Heart Survey","volume":"138","author":"Pisters","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.jamda.2018.04.017_bib35","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/ageing\/afn293","article-title":"The impact of frailty on the utilization of antithrombotic therapy in older patients with atrial fibrillation","volume":"38","author":"Perera","year":"2009","journal-title":"Age Ageing"},{"issue":"9921","key":"10.1016\/j.jamda.2018.04.017_bib36","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: A meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jamda.2018.04.017_bib37","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/jgs.12799","article-title":"New oral anticoagulants in elderly adults: Evidence from a meta-analysis of randomized trials","volume":"62","author":"Sardar","year":"2014","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jamda.2018.04.017_bib38","doi-asserted-by":"crossref","first-page":"1103.e1","DOI":"10.1016\/j.jamda.2015.09.008","article-title":"Clinical and safety outcomes of oral antithrombotics for stroke prevention in atrial fibrillation: A systematic review and network meta-analysis","volume":"16","author":"Lin","year":"2015","journal-title":"J\u00a0Am Med Dir Assoc"},{"key":"10.1016\/j.jamda.2018.04.017_bib39","first-page":"767","article-title":"Effectiveness and safety of oral anticoagulants in older patients with atrial fibrillation: A systematic review and meta-regression analysis","volume":"5","author":"Bai","year":"2017","journal-title":"Age Ageing"},{"key":"10.1016\/j.jamda.2018.04.017_bib40","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1160\/TH15-03-0247","article-title":"Dabigatran use in elderly patients with atrial fibrillation","volume":"115","author":"Avgil-Tsadok","year":"2016","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jamda.2018.04.017_bib41","doi-asserted-by":"crossref","first-page":"h1857","DOI":"10.1136\/bmj.h1857","article-title":"Comparative risk of gastrointestinal bleeding with dabigatran, rivaroxaban, and warfarin: Population based cohort study","volume":"350","author":"Abraham","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.jamda.2018.04.017_bib42","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1053\/j.gastro.2016.12.018","article-title":"Gastrointestinal safety of direct oral anticoagulants: A large population-based study","volume":"152","author":"Abraham","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jamda.2018.04.017_bib43","doi-asserted-by":"crossref","first-page":"j510","DOI":"10.1136\/bmj.j510","article-title":"Effectiveness and safety of reduced dose non-vitamin K antagonist oral anticoagulants and warfarin in patients with atrial fibrillation: propensity weighted nationwide cohort study","volume":"356","author":"Nielsen","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.jamda.2018.04.017_bib44","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1136\/heartjnl-2017-311162","article-title":"Oral anticoagulation for elderly patients with non-valvular atrial fibrillation: Recent insights from randomised trials and the \u201creal world\u201d","volume":"103","author":"Voukalis","year":"2017","journal-title":"Heart"}],"container-title":["Journal of the American Medical Directors Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525861018302342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525861018302342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T12:43:15Z","timestamp":1717332195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525861018302342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S1525861018302342"],"URL":"https:\/\/doi.org\/10.1016\/j.jamda.2018.04.017","relation":{},"ISSN":["1525-8610"],"issn-type":[{"value":"1525-8610","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of Direct Oral Anticoagulants and Vitamin K Antagonists in Oldest Old Patients: A Prospective Study","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Medical Directors Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jamda.2018.04.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 AMDA - The Society for Post-Acute and Long-Term Care Medicine.","name":"copyright","label":"Copyright"}]}}