{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:30:54Z","timestamp":1786991454574,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100013206","name":"Food Institutional Research Measure","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008303","name":"Department for Employment and Learning, Northern Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008303","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jamda.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Medical Directors Association"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jamda.2018.11.031","type":"journal-article","created":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T03:52:58Z","timestamp":1548561178000},"page":"551-557.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["B-vitamins in Relation to Depression in Older Adults Over 60\u00a0Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-4295","authenticated-orcid":false,"given":"Katie","family":"Moore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine F.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leane","family":"Hoey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6470-1728","authenticated-orcid":false,"given":"Mary","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conal","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Strain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"McCarroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam C.","family":"Casey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergal","family":"Tracey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eamon","family":"Laird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"O'Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"McNulty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jamda.2018.11.031_bib1","series-title":"World Population Prospects: The 2015 Revision, Key Findings and Advance Tables","year":"2015"},{"key":"10.1016\/j.jamda.2018.11.031_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1192\/bjp.bp.115.180463","article-title":"Prevalence of mental disorders in elderly people: The European MentDis_ICF65+ study","volume":"210","author":"Andreas","year":"2016","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jamda.2018.11.031_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jamda.2014.10.023","article-title":"Depression, frailty, and all-cause mortality: A cohort study of men older than 75 years","volume":"16","author":"Almeida","year":"2015","journal-title":"J\u00a0Am Med Dir Assoc"},{"key":"10.1016\/j.jamda.2018.11.031_bib5","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jamda.2018.11.031_bib6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1017\/S0029665117004177","article-title":"Diet, nutrition and the ageing brain: Current evidence and new directions","volume":"77","author":"Moore","year":"2018","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.jamda.2018.11.031_bib7","first-page":"1636","article-title":"Biomarkers of nutrition for development\u2014folate review","volume":"145","author":"Bailey","year":"2015","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.jamda.2018.11.031_bib8","series-title":"Folate in Health and Disease","article-title":"Folate and neurological disease","author":"Bottiglieri","year":"2005"},{"key":"10.1016\/j.jamda.2018.11.031_bib9","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1136\/bmj.4.5578.512","article-title":"Serum folate values in 423 psychiatric patients","volume":"4","author":"Carney","year":"1967","journal-title":"Br Med J"},{"key":"10.1016\/j.jamda.2018.11.031_bib10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1192\/S0007125000193250","article-title":"Folate deficiency in depressive illness","volume":"117","author":"Reynolds","year":"1970","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jamda.2018.11.031_bib11","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1136\/bmj.281.6247.1036","article-title":"The neuropsychiatry of megaloblastic anaemia","volume":"281","author":"Shorvon","year":"1980","journal-title":"Br Med J"},{"key":"10.1016\/j.jamda.2018.11.031_bib12","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1080\/13607863.2015.1049115","article-title":"Folate and B12 serum levels\u00a0in\u00a0association with depression in the aged: A systematic review and meta-analysis","volume":"20","author":"Petridou","year":"2016","journal-title":"Aging Ment Health"},{"key":"10.1016\/j.jamda.2018.11.031_bib13","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/jgs.15258","article-title":"Impact of area-level socioeconomic deprivation on the risk of cognitive dysfunction in older adults","volume":"66","author":"McCann","year":"2018","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jamda.2018.11.031_bib14","series-title":"Community Surveys of Psychiatric Disorders","article-title":"The community mental health assessment survey and the CES-D Scale","author":"Radloff","year":"1986"},{"key":"10.1016\/j.jamda.2018.11.031_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.jamda.2018.11.031_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-Mental State.\u201d A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.jamda.2018.11.031_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0076-6879(97)81007-5","article-title":"Microbiological assay for serum, plasma, and red cell folate using cryopreserved, microtiter plate method","volume":"281","author":"Molloy","year":"1997","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jamda.2018.11.031_bib18","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1136\/jcp.44.7.592","article-title":"Microbiological assay for vitamin-B-12 performed in 96-well microtitre plates","volume":"44","author":"Kelleher","year":"1991","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.jamda.2018.11.031_bib19","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/clinchem\/45.4.569a","article-title":"Fully automated measurement of total homocysteine in plasma and serum on the Abbott IMx analyzer","volume":"45","author":"Leino","year":"1999","journal-title":"Clin Chem"},{"key":"10.1016\/j.jamda.2018.11.031_bib20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0009-8981(98)00173-9","article-title":"A\u00a0simple, sensitive and reproducible assay for pyridoxal 5'-phosphate and 4-pyridoxic acid in human plasma","volume":"280","author":"Bates","year":"1999","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jamda.2018.11.031_bib21","first-page":"413","article-title":"The relative effectiveness or iron and iron with riboflavin in correcting a microcytic anaemia in men and children in rural Gambia","volume":"37","author":"Powers","year":"1983","journal-title":"Hum Nutr Clin Nutr"},{"key":"10.1016\/j.jamda.2018.11.031_bib22","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/ajcn\/86.5.1405","article-title":"Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults","volume":"86","author":"Hoey","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jamda.2018.11.031_bib23","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1532-5415.1991.tb01616.x","article-title":"The timed \u201cup and Go\u201d: A test of basic functional mobility for frail elderly persons","volume":"39","author":"Podsiadlo","year":"1991","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jamda.2018.11.031_bib24","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/jech.2006.050385","article-title":"Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity","volume":"61","author":"Gilbody","year":"2007","journal-title":"J\u00a0Epidemiol Commun Health"},{"key":"10.1016\/j.jamda.2018.11.031_bib25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3945\/ajcn.113.062752","article-title":"Biomarker responses to folic acid intervention in healthy adults: A meta-analysis of randomized controlled trials","volume":"99","author":"Duffy","year":"2014","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jamda.2018.11.031_bib26","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3945\/ajcn.2010.29413","article-title":"Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time","volume":"92","author":"Skarupski","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jamda.2018.11.031_bib27","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/ejcn.2015.202","article-title":"Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: The Quebec Longitudinal Study on Nutrition and Aging","volume":"70","author":"Gougeon","year":"2016","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jamda.2018.11.031_bib28","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/PSY.0b013e3181f61863","article-title":"Serum folate, vitamin B-12, and homocysteine and their association with depressive symptoms among U.S. adults","volume":"72","author":"Beydoun","year":"2010","journal-title":"Psychosom Med"},{"key":"10.1016\/j.jamda.2018.11.031_bib29","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1192\/bjp.bp.107.039511","article-title":"Predictive value of folate, vitamin B-12 and homocysteine levels in late-life depression","volume":"192","author":"Kim","year":"2008","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jamda.2018.11.031_bib30","first-page":"188","article-title":"Assessing biomarker status of vitamin B12 in the laboratory: No simple solution","volume":"55","author":"McNulty","year":"2017","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.jamda.2018.11.031_bib31","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/07315724.2008.10719720","article-title":"Vitamin B6 is associated with depressive symptomatology in Massachusetts elders","volume":"27","author":"Merete","year":"2008","journal-title":"J\u00a0Am Coll Nutr"},{"key":"10.1016\/j.jamda.2018.11.031_bib32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1192\/bjp.141.3.271","article-title":"Thiamine, riboflavin and pyridoxine deficiency in psychiatric in-patients","volume":"141","author":"Carney","year":"1982","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jamda.2018.11.031_bib33","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.nut.2007.10.013","article-title":"Dietary intake of folate, other B vitamins, and omega-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults","volume":"24","author":"Murakami","year":"2008","journal-title":"Nutrition"},{"key":"10.1016\/j.jamda.2018.11.031_bib34","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/ajcn\/68.2.389","article-title":"Riboflavin and vitamin B-6 intakes and status and biochemical response to riboflavin supplementation in free-living elderly people","volume":"68","author":"Madigan","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jamda.2018.11.031_bib35","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/archpsyc.60.6.618","article-title":"Folate, vitamin B-12, homocysteine, and the MTHFR 677C -> T polymorphism in anxiety and depression\u2014the Hordaland Homocysteine Study","volume":"60","author":"Bjelland","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jamda.2018.11.031_bib36","doi-asserted-by":"crossref","first-page":"621453","DOI":"10.1155\/2013\/621453","article-title":"The effect of methylated vitamin B complex on depressive and anxiety symptoms and quality of life in adults with depression","volume":"2013","author":"Lewis","year":"2013","journal-title":"ISRN Psychiatry"},{"key":"10.1016\/j.jamda.2018.11.031_bib37","first-page":"1121","article-title":"Association between anxiety and hypertension: A\u00a0systematic review and meta-analysis of epidemiological studies","volume":"11","author":"Pan","year":"2015","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.jamda.2018.11.031_bib38","first-page":"k1334","article-title":"Do the benefits of folic acid fortification outweigh the risk of masking vitamin B12 deficiency?","volume":"360","author":"Mills","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.jamda.2018.11.031_bib39","series-title":"Basic Neurochemistry: Molecular, Cellular and Medical Aspects","article-title":"Serotonin","author":"Hensler","year":"2006"},{"key":"10.1016\/j.jamda.2018.11.031_bib40","doi-asserted-by":"crossref","first-page":"e0155431","DOI":"10.1371\/journal.pone.0155431","article-title":"Screening for depression in the general population with the center for Epidemiologic studies depression (CES-D): A systematic review with meta-analysis","volume":"11","author":"Vilagut","year":"2016","journal-title":"PLoS One"}],"container-title":["Journal of the American Medical Directors Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525861018306996?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525861018306996?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:17:41Z","timestamp":1761506261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525861018306996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S1525861018306996"],"URL":"https:\/\/doi.org\/10.1016\/j.jamda.2018.11.031","relation":{},"ISSN":["1525-8610"],"issn-type":[{"value":"1525-8610","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"B-vitamins in Relation to Depression in Older Adults Over 60\u00a0Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Medical Directors Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jamda.2018.11.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2018 Published by Elsevier Inc. on behalf of AMDA - The Society for Post-Acute and Long-Term Care Medicine.","name":"copyright","label":"Copyright"}]}}