{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:43:56Z","timestamp":1781869436867,"version":"3.54.5"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2634-F-010-001"],"award-info":[{"award-number":["MOST 110-2634-F-010-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110\\u20132634-F-010\\u2013001"],"award-info":[{"award-number":["110\\u20132634-F-010\\u2013001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2634-F-010-001"],"award-info":[{"award-number":["109-2634-F-010-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jamda.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Medical Directors Association"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jamda.2021.06.035","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T05:24:39Z","timestamp":1627363479000},"page":"468-474.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Detecting Suspected Prescribing Cascades by Prescription Sequence Symmetry Analysis of Nationwide Real-World Data"],"prefix":"10.1016","volume":"23","author":[{"given":"Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Tsung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsui-Chuan","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ning","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1660-9120","authenticated-orcid":false,"given":"Fei-Yuan","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2387-8508","authenticated-orcid":false,"given":"Liang-Kung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jamda.2021.06.035_bib1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/jgs.15800","article-title":"Assessing the scope and appropriateness of prescribing cascades","volume":"67","author":"McCarthy","year":"2019","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jamda.2021.06.035_bib2","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1111\/jgs.15543","article-title":"What is known about preventing, detecting, and reversing prescribing cascades: A scoping review","volume":"66","author":"Brath","year":"2018","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jamda.2021.06.035_bib3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0140-6736(95)92656-9","article-title":"Drug therapy","volume":"346","author":"Rochon","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jamda.2021.06.035_bib4","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/S0140-6736(17)31188-1","article-title":"The prescribing cascade revisited","volume":"389","author":"Rochon","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jamda.2021.06.035_bib5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2147\/CIA.S99097","article-title":"Hospitalization in older patients due to adverse drug reactions\u2014the need for a prediction tool","volume":"11","author":"Parameswaran Nair","year":"2016","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.jamda.2021.06.035_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1445-5994.2001.00044.x","article-title":"Adverse drug events as a cause of hospital admission in the elderly","volume":"31","author":"Chan","year":"2001","journal-title":"Intern Med J"},{"key":"10.1016\/j.jamda.2021.06.035_bib7","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/jgs.15767","article-title":"American Geriatrics Society 2019 Updated AGS Beers Criteria(R) for potentially inappropriate medication use in older adults","volume":"67","year":"2019","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.jamda.2021.06.035_bib8","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/ageing\/afm118","article-title":"START (screening tool to alert doctors to the right treatment)--an evidence-based screening tool to detect prescribing omissions in elderly patients","volume":"36","author":"Barry","year":"2007","journal-title":"Age Aging"},{"key":"10.1016\/j.jamda.2021.06.035_bib9","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1001\/jamainternmed.2019.1288","article-title":"The dangers of ignoring the Beers criteria\u2014the prescribing cascade","volume":"179","author":"DeRhodes","year":"2019","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jamda.2021.06.035_bib10","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10654-017-0281-8","article-title":"Sequence symmetry analysis in pharmacovigilance and pharmacoepidemiologic studies","volume":"32","author":"Lai","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jamda.2021.06.035_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2147\/CLEP.S196293","article-title":"Taiwan's national health insurance research database: Past and future","volume":"11","author":"Hsieh","year":"2019","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.jamda.2021.06.035_bib12","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/pds.3417","article-title":"The validity of sequence symmetry analysis (SSA) for adverse drug reaction signal detection","volume":"22","author":"Wahab","year":"2013","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jamda.2021.06.035_bib13","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/pds.3780","article-title":"Prescription sequence symmetry analysis: Assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries","volume":"24","author":"Pratt","year":"2015","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jamda.2021.06.035_bib14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1365-2125.2009.03571.x","article-title":"Misdiagnosis and mistreatment of a common side-effect--angiotensin-converting enzyme inhibitor-induced cough","volume":"69","author":"Vegter","year":"2010","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jamda.2021.06.035_bib15","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s40264-013-0085-z","article-title":"Angiotensin-converting enzyme inhibitor treatment and the development of urinary tract infections: A prescription sequence symmetry analysis","volume":"36","author":"Pouwels","year":"2013","journal-title":"Drug Saf"},{"key":"10.1016\/j.jamda.2021.06.035_bib16","doi-asserted-by":"crossref","first-page":"762","DOI":"10.5414\/CP202113","article-title":"Association of statin use with storage lower urinary tract symptoms (LUTS): Data mining of prescription database","volume":"52","author":"Fujimoto","year":"2014","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1016\/j.jamda.2021.06.035_bib17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1099-1557(199811\/12)7:6<399::AID-PDS385>3.0.CO;2-C","article-title":"Cholesterol-lowering drugs and antidepressants--a study of prescription symmetry","volume":"7","author":"Lindberg","year":"1998","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jamda.2021.06.035_bib18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s40264-014-0163-x","article-title":"Association of statin use with sleep disturbances: Data mining of a spontaneous reporting database and a prescription database","volume":"37","author":"Takada","year":"2014","journal-title":"Drug Saf"},{"key":"10.1016\/j.jamda.2021.06.035_bib19","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2147\/TCRM.S204860","article-title":"Association of atorvastatin with the risk of hepatotoxicity: A pilot prescription sequence symmetry analysis","volume":"15","author":"Zhang","year":"2019","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.jamda.2021.06.035_bib20","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/pds.1250","article-title":"Statins and nonsteroidal anti-inflammatory drugs-an analysis of prescription symmetry","volume":"15","author":"Silwer","year":"2006","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jamda.2021.06.035_bib21","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1111\/bcp.14077","article-title":"A\u00a0sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections","volume":"85","author":"Ko","year":"2019","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jamda.2021.06.035_bib22","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1002\/pds.4052","article-title":"Association between statins and infections among patients with diabetes: A cohort and prescription sequence symmetry analysis","volume":"25","author":"Pouwels","year":"2016","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jamda.2021.06.035_bib23","doi-asserted-by":"crossref","first-page":"807","DOI":"10.5414\/CP201914","article-title":"Difference between the frequencies of antisecretory drug prescriptions in users of buffered vs. enteric-coated low-dose aspirin therapies","volume":"51","author":"Hachiken","year":"2013","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1016\/j.jamda.2021.06.035_bib24","doi-asserted-by":"crossref","first-page":"e1918425","DOI":"10.1001\/jamanetworkopen.2019.18425","article-title":"Magnitude of and characteristics associated with the treatment of calcium channel blocker-induced lower-extremity edema with loop diuretics","volume":"2","author":"Vouri","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jamda.2021.06.035_bib25","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.japh.2018.06.014","article-title":"An evaluation of a potential calcium channel blocker-lower-extremity edema-loop diuretic prescribing cascade","volume":"58","author":"Vouri","year":"2018","journal-title":"J\u00a0Am Pharm Assoc"},{"key":"10.1016\/j.jamda.2021.06.035_bib26","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ijmedinf.2015.06.001","article-title":"NHI-PharmaCloud in Taiwan--A preliminary evaluation using the RE-AIM framework and lessons learned","volume":"84","author":"Huang","year":"2015","journal-title":"Int J Med Inform"},{"key":"10.1016\/j.jamda.2021.06.035_bib28","first-page":"532","article-title":"Physicians' adherence to guidelines for empirical treatment of urinary tract infection in Taiwan","volume":"40","author":"Jan","year":"2007","journal-title":"J\u00a0Microbiol Immunol Infect"}],"container-title":["Journal of the American Medical Directors Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525861021006010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525861021006010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:49:53Z","timestamp":1778816993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525861021006010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1525861021006010"],"URL":"https:\/\/doi.org\/10.1016\/j.jamda.2021.06.035","relation":{},"ISSN":["1525-8610"],"issn-type":[{"value":"1525-8610","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detecting Suspected Prescribing Cascades by Prescription Sequence Symmetry Analysis of Nationwide Real-World Data","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Medical Directors Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jamda.2021.06.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 AMDA - The Society for Post-Acute and Long-Term Care Medicine.","name":"copyright","label":"Copyright"}]}}