{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:27:59Z","timestamp":1793975279298,"version":"4.8.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["JPMH20FA1006"],"award-info":[{"award-number":["JPMH20FA1006"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jamda.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Medical Directors Association"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jamda.2023.09.028","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T18:01:46Z","timestamp":1698861706000},"page":"417-430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Dose-Response Relationship of Physical Activity with All-Cause Mortality among Older Adults: An Umbrella Review"],"prefix":"10.1016","volume":"25","author":[{"given":"Noritoshi","family":"Fukushima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Sasai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Kiyohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu S.","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Machida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Amagasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1931-2613","authenticated-orcid":false,"given":"Shigeru","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jamda.2023.09.028_bib1","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1136\/bjsports-2014-094306","article-title":"Even a low-dose of moderate-to-vigorous physical activity reduces mortality by 22% in adults aged \u226560 years: a systematic review and meta-analysis","volume":"49","author":"Hupin","year":"2015","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib2","doi-asserted-by":"crossref","first-page":"7704","DOI":"10.18632\/aging.103057","article-title":"Physical activity and successful aging among middle-aged and older adults: a systematic review and meta-analysis of cohort studies","volume":"12","author":"Lin","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jamda.2023.09.028_bib3","first-page":"359","article-title":"Definitions of successful ageing: a brief review of a multidimensional concept","volume":"90","author":"Urtamo","year":"2019","journal-title":"Acta Biomed"},{"key":"10.1016\/j.jamda.2023.09.028_bib6","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1139\/apnm-2020-0467","article-title":"Canadian 24-hour movement guidelines for adults aged 18-64 years and adults aged 65 years or older: an integration of physical activity, sedentary behaviour, and sleep","volume":"45","author":"Ross","year":"2020","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.jamda.2023.09.028_bib7","series-title":"2018 Physical Activity Guidelines Advisory Committee Scientific Report","year":"2018"},{"key":"10.1016\/j.jamda.2023.09.028_bib8","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","article-title":"World Health Organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Bull","year":"2020","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib9","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.1038\/s41467-021-24956-2","article-title":"Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function","volume":"12","author":"Grevendonk","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jamda.2023.09.028_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/jcsm.12139","article-title":"The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men","volume":"8","author":"St-Jean-Pelletier","year":"2017","journal-title":"J\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jamda.2023.09.028_bib11","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jamda.2023.09.028_bib12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"key":"10.1016\/j.jamda.2023.09.028_bib13","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"Amstar 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.jamda.2023.09.028_bib14","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.jamda.2023.09.028_bib16","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1249\/MSS.0000000000000517","article-title":"Definition, measurement, and health risks associated with sedentary behavior","volume":"47","author":"Gibbs","year":"2015","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jamda.2023.09.028_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ypmed.2020.106356","article-title":"Objectively measured physical activity and all cause mortality: a systematic review and meta-analysis","volume":"143","author":"Ramakrishnan","year":"2021","journal-title":"Prev Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib18","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1177\/2047487318795194","article-title":"Associations of leisure-time physical activity with cardiovascular mortality: a systematic review and meta-analysis of 44 prospective cohort studies","volume":"25","author":"Cheng","year":"2018","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jamda.2023.09.028_bib19","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s10654-018-0374-z","article-title":"Lifestyle factors, cardiovascular disease and all-cause mortality in middle-aged and elderly women: a systematic review and meta-analysis","volume":"33","author":"Colpani","year":"2018","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.jamda.2023.09.028_bib20","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/ije\/dyr112","article-title":"Domains of physical activity and all-cause mortality: systematic review and dose-response meta-analysis of cohort studies","volume":"40","author":"Samitz","year":"2011","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jamda.2023.09.028_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/ije\/dyq104","article-title":"Non-vigorous physical activity and all-cause mortality: systematic review and meta-analysis of cohort studies","volume":"40","author":"Woodcock","year":"2011","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jamda.2023.09.028_bib22","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1136\/bjsports-2018-100393","article-title":"Association of high amounts of physical activity with mortality risk: a systematic review and meta-analysis","volume":"54","author":"Blond","year":"2020","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cmpb.2009.11.005","article-title":"From floated to conventional confidence intervals for the relative risks based on published dose-response data","volume":"98","author":"Orsini","year":"2010","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1016\/j.jamda.2023.09.028_bib24","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jclinepi.2013.11.007","article-title":"Systematic review finds overlapping reviews were not mentioned in every other overview","volume":"67","author":"Pieper","year":"2014","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jamda.2023.09.028_bib25","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/ije\/dyy024","article-title":"Association of leisure-time physical activity with total and cause-specific mortality: a pooled analysis of nearly a half million adults in the Asia Cohort Consortium","volume":"47","author":"Liu","year":"2018","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jamda.2023.09.028_bib26","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1001\/jamainternmed.2018.5406","article-title":"Association of long-term exercise training with risk of falls, fractures, hospitalizations, and mortality in older adults: a systematic review and meta-analysis","volume":"179","author":"de Souto Barreto","year":"2019","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib27","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s40279-020-01259-y","article-title":"Safety and effectiveness of long-term exercise interventions in older adults: a systematic review and meta-analysis of randomized controlled trials","volume":"50","author":"Garc\u00eda-Hermoso","year":"2020","journal-title":"Sports Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101061","article-title":"Instrumented measures of sedentary behaviour and physical activity are associated with mortality in community-dwelling older adults: a systematic review, meta-analysis and meta-regression analysis","volume":"61","author":"Rojer","year":"2020","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jamda.2023.09.028_bib29","first-page":"517","article-title":"The effect of therapeutic exercise interventions on physical and psychosocial outcomes in adults aged 80 years and older: a systematic review and meta-analysis","volume":"30","author":"Nicolson","year":"2022","journal-title":"J\u00a0Aging Phys Act"},{"key":"10.1016\/j.jamda.2023.09.028_bib30","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1080\/02640414.2022.2099186","article-title":"Dose-response association between the daily step count and all-cause mortality: a systematic review and meta-analysis","volume":"40","author":"Liu","year":"2022","journal-title":"J\u00a0Sports Sci"},{"key":"10.1016\/j.jamda.2023.09.028_bib31","doi-asserted-by":"crossref","first-page":"774","DOI":"10.33963\/KP.a2022.0120","article-title":"Accelerometer-measured light-intensity physical activity and the risk of cardiovascular disease or death in older adults: a meta-analysis","volume":"80","author":"Bo","year":"2022","journal-title":"Kardiol Pol"},{"key":"10.1016\/j.jamda.2023.09.028_bib32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s40279-021-01536-4","article-title":"Daily step count and all-cause mortality: a dose-response meta-analysis of prospective cohort studies","volume":"52","author":"Jayedi","year":"2021","journal-title":"Sports Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib33","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jamainternmed.2015.0533","article-title":"Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship","volume":"175","author":"Arem","year":"2015","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001335","article-title":"Leisure time physical activity of moderate to vigorous intensity and mortality: a large pooled cohort analysis","volume":"9","author":"Moore","year":"2012","journal-title":"PLoS Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0028-1128150","article-title":"Physical activity and all-cause mortality: an updated meta-analysis with different intensity categories","volume":"30","author":"L\u00f6llgen","year":"2009","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib36","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1249\/MSS.0000000000001939","article-title":"Physical activity, all-cause and cardiovascular mortality, and cardiovascular Disease","volume":"51","author":"Kraus","year":"2019","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jamda.2023.09.028_bib37","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.amepre.2010.12.016","article-title":"Physical activity in U.S.: adults compliance with the physical activity guidelines for Americans","volume":"40","author":"Tucker","year":"2011","journal-title":"Am J Prev Med"},{"key":"10.1016\/j.jamda.2023.09.028_bib38","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/aje\/kwm148","article-title":"The role of measurement error in estimating levels of physical activity","volume":"166","author":"Ferrari","year":"2007","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jamda.2023.09.028_bib40","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.3390\/ijerph18073577","article-title":"Normative data of objectively measured physical activity and sedentary time in community-dwelling older Japanese","volume":"18","author":"Yatsugi","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jamda.2023.09.028_bib41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1249\/MSS.0b013e3182a0595f","article-title":"Comparison of self-reported versus accelerometer-measured physical activity","volume":"46","author":"Dyrstad","year":"2014","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jamda.2023.09.028_bib42","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/jech.2003.008466","article-title":"Bias","volume":"58","author":"Delgado-Rodr\u00edguez","year":"2004","journal-title":"J\u00a0Epidemiol Community Health"},{"key":"10.1016\/j.jamda.2023.09.028_bib43","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/aje\/kwx246","article-title":"Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population","volume":"186","author":"Fry","year":"2017","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jamda.2023.09.028_bib44","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/aje\/kws125","article-title":"Patterns of 12-year change in physical activity levels in community-dwelling older women: can modest levels of physical activity help older women live longer?","volume":"176","author":"Xue","year":"2012","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jamda.2023.09.028_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0286527","article-title":"Comparison of mortality and hospitalizations of older adults living in residential care facilities versus nursing homes or the community. A systematic review","volume":"18","author":"Boucaud-Maitre","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.jamda.2023.09.028_bib46","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jamda.2021.05.037","article-title":"Impact of tailored multicomponent exercise for preventing weakness and falls on nursing home residents' functional capacity","volume":"23","author":"Courel-Ib\u00e1\u00f1ez","year":"2022","journal-title":"J\u00a0Am Med Dir Assoc"},{"key":"10.1016\/j.jamda.2023.09.028_bib47","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1249\/mss.0b013e31815a51b3","article-title":"Physical activity in the United States measured by accelerometer","volume":"40","author":"Troiano","year":"2008","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.jamda.2023.09.028_bib48","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12966-018-0695-z","article-title":"Is objectively measured light-intensity physical activity associated with health outcomes after adjustment for moderate-to-vigorous physical activity in adults? A systematic review","volume":"15","author":"Amagasa","year":"2018","journal-title":"Int J Behav Nutr Phys Act"},{"key":"10.1016\/j.jamda.2023.09.028_bib49","doi-asserted-by":"crossref","first-page":"l2323","DOI":"10.1136\/bmj.l2323","article-title":"Physical activity trajectories and mortality: population based cohort study","volume":"365","author":"Mok","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.jamda.2023.09.028_bib50","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.0355","article-title":"Association of leisure-time physical activity across the adult life course with all-cause and cause-specific mortality","volume":"2","author":"Saint-Maurice","year":"2019","journal-title":"JAMA Netw Open"}],"container-title":["Journal of the American Medical Directors Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525861023008356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525861023008356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:33:27Z","timestamp":1761507207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525861023008356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1525861023008356"],"URL":"https:\/\/doi.org\/10.1016\/j.jamda.2023.09.028","relation":{},"ISSN":["1525-8610"],"issn-type":[{"value":"1525-8610","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose-Response Relationship of Physical Activity with All-Cause Mortality among Older Adults: An Umbrella Review","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Medical Directors Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jamda.2023.09.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of AMDA \u2013 The Society for Post-Acute and Long-Term Care Medicine.","name":"copyright","label":"Copyright"}]}}