{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:31:22Z","timestamp":1787160682779,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","jamda.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Medical Directors Association"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jamda.2024.105239","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:47:28Z","timestamp":1725410848000},"page":"105239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Frailty in Persons with Down Syndrome: Results from the REVIVIS Study"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8801-0294","authenticated-orcid":false,"given":"Federico","family":"Bellelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Consorti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Garlini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Recalcati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Froldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Proietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Cesari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jamda.2024.105239_bib1","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1056\/NEJMra1706537","article-title":"Down syndrome","volume":"382","author":"Bull","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jamda.2024.105239_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abi4888","article-title":"Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity","volume":"14","author":"Lambert","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jamda.2024.105239_bib3","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/ajmg.a.38512","article-title":"Co-occurring medical conditions in adults with Down syndrome: a systematic review toward the development of health care guidelines","volume":"176","author":"Capone","year":"2018","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jamda.2024.105239_bib4","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/alz.12112","article-title":"Further understanding the connection between Alzheimer\u2019s disease and Down syndrome","volume":"16","author":"Snyder","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jamda.2024.105239_bib5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00281-020-00804-1","article-title":"Down syndrome, accelerated aging and immunosenescence","volume":"42","author":"Gensous","year":"2020","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jamda.2024.105239_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.dhjo.2020.100947","article-title":"Cause of death in adults with Down syndrome in the United States","volume":"13","author":"Landes","year":"2020","journal-title":"Disabil Health J"},{"key":"10.1016\/j.jamda.2024.105239_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12903","article-title":"Accelerated bio-cognitive aging in Down syndrome: state of the art and possible deceleration strategies","volume":"18","author":"Franceschi","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.jamda.2024.105239_bib8","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1100\/tsw.2002.861","article-title":"The accumulation of deficits with age and possible invariants of aging","volume":"2","author":"Mitnitski","year":"2002","journal-title":"Sci World J"},{"key":"10.1016\/j.jamda.2024.105239_bib9","first-page":"489","article-title":"A\u00a0global clinical measure of fitness and frailty in elderly people","volume":"173","author":"Rockwood","year":"2005","journal-title":"J\u00a0Assoc Medicale Can"},{"key":"10.1016\/j.jamda.2024.105239_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2318-8-24","article-title":"A\u00a0standard procedure for creating a frailty index","volume":"8","author":"Searle","year":"2008","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.jamda.2024.105239_bib11","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.ridd.2014.05.022","article-title":"Predicting disabilities in daily functioning in older people with intellectual disabilities using a frailty index","volume":"35","author":"Schoufour","year":"2014","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.jamda.2024.105239_bib12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ageing\/afaa219","article-title":"Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies","volume":"50","author":"O\u2019Caoimh","year":"2021","journal-title":"Age Ageing"},{"key":"10.1016\/j.jamda.2024.105239_bib13","first-page":"326","article-title":"Relationship among age, education and frailty in older persons","volume":"12","author":"Bellelli","year":"2023","journal-title":"J\u00a0Frailty Aging"},{"key":"10.1016\/j.jamda.2024.105239_bib14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1741-7015-10-4","article-title":"Frailty in primary care: a review of its conceptualization and implications for practice","volume":"10","author":"Lacas","year":"2012","journal-title":"BMC Med"},{"key":"10.1016\/j.jamda.2024.105239_bib15","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3390\/ijerph18031263","article-title":"Relation among caregivers\u2019 burden, abuse and behavioural disorder in people with dementia","volume":"18","author":"Gimeno","year":"2021","journal-title":"Int J Environ Res Publ Health"},{"key":"10.1016\/j.jamda.2024.105239_bib16","author":"Alliance"},{"key":"10.1016\/j.jamda.2024.105239_bib17","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1590\/2237-6089-2016-0085","article-title":"High burden and frailty: association with poor cognitive performance in older caregivers living in rural areas","volume":"39","author":"Brigola","year":"2017","journal-title":"Trends Psychiatry Psychother"},{"key":"10.1016\/j.jamda.2024.105239_bib18","first-page":"699","article-title":"Caregiver care","volume":"99","author":"Swartz","year":"2019","journal-title":"Am Fam Physician"}],"container-title":["Journal of the American Medical Directors Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525861024006613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525861024006613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:43:13Z","timestamp":1730940193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525861024006613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1525861024006613"],"URL":"https:\/\/doi.org\/10.1016\/j.jamda.2024.105239","relation":{},"ISSN":["1525-8610"],"issn-type":[{"value":"1525-8610","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frailty in Persons with Down Syndrome: Results from the REVIVIS Study","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Medical Directors Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jamda.2024.105239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Post-Acute and Long-Term Care Medical Association.","name":"copyright","label":"Copyright"}],"article-number":"105239"}}