{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:04:50Z","timestamp":1779782690827,"version":"3.53.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18dk0207027h0003"],"award-info":[{"award-number":["18dk0207027h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H06286"],"award-info":[{"award-number":["17H06286"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K23845"],"award-info":[{"award-number":["24K23845"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jamda.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Medical Directors Association"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jamda.2025.105855","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:16:26Z","timestamp":1758068186000},"page":"105855","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relative Hypothermia and Gray Matter Atrophy in Older Adults: A Cross-Sectional Study"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9468-3783","authenticated-orcid":false,"given":"Daiki","family":"Yamagiwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoma","family":"Akaida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jamda.2025.105855_bib1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jns.2017.06.030","article-title":"Worldwide trends in the prevalence of dementia","volume":"379","author":"Cova","year":"2017","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jamda.2025.105855_bib2","series-title":"Handbook of Clinical Neurology","first-page":"231","article-title":"Chapter 13 - Alzheimer's disease","author":"Soria Lopez","year":"2019"},{"key":"10.1016\/j.jamda.2025.105855_bib3","first-page":"123","article-title":"Alzheimer's disease - why we need early diagnosis","volume":"9","author":"Rasmussen","year":"2019","journal-title":"Degener Neurol Neuromuscul Dis"},{"key":"10.1016\/j.jamda.2025.105855_bib4","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1002\/alz.12837","article-title":"Improving community health-care systems' early detection of cognitive decline and dementia","volume":"18","year":"2022","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jamda.2025.105855_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105748","article-title":"Association between lower body temperature and increased tau pathology in cognitively normal older adults","volume":"171","author":"Blessing","year":"2022","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jamda.2025.105855_bib6","doi-asserted-by":"crossref","first-page":"105472","DOI":"10.1016\/j.jamda.2024.105472","article-title":"Association between relative hypothermia and cognitive function in older adults: a cross-sectional study","volume":"26","author":"Yamagiwa","year":"2025","journal-title":"J Am Med Dir Assoc"},{"key":"10.1016\/j.jamda.2025.105855_bib7","article-title":"Structure and pathology of tau protein in Alzheimer disease","volume":"2012","author":"Kolarova","year":"2012","journal-title":"Int J Alzheimers Dis"},{"key":"10.1016\/j.jamda.2025.105855_bib8","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.ijbiomac.2020.07.327","article-title":"Role of tau protein in Alzheimer's disease: the prime pathological player","volume":"163","author":"Muralidar","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jamda.2025.105855_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.21037\/atm.2018.04.23","article-title":"Tau in neurodegenerative disease","volume":"6","author":"Gao","year":"2018","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jamda.2025.105855_bib10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.psc.2022.07.010","article-title":"Cognitive impairment in older adults: epidemiology, diagnosis, and treatment","volume":"45","author":"P\u00e9rez Palmer","year":"2022","journal-title":"Psychiatr Clin North Am"},{"key":"10.1016\/j.jamda.2025.105855_bib11","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrneurol.2013.107","article-title":"Ushering in the study and treatment of preclinical Alzheimer disease","volume":"9","author":"Langbaum","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jamda.2025.105855_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1515\/REVNEURO.2010.21.3.187","article-title":"Structural brain changes in aging: courses, causes and cognitive consequences","volume":"21","author":"Fjell","year":"2010","journal-title":"Rev Neurosci"},{"key":"10.1016\/j.jamda.2025.105855_bib13","doi-asserted-by":"crossref","first-page":"825.e25-36","DOI":"10.1016\/j.neurobiolaging.2011.05.018","article-title":"Structural MRI changes detectable up to ten years before clinical Alzheimer's disease","volume":"33","author":"Tondelli","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jamda.2025.105855_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2022.886619","article-title":"Brain structural and functional changes in cognitive impairment due to Alzheimer's disease","volume":"13","author":"\u00c1vila-Villanueva","year":"2022","journal-title":"Front Psychol"},{"key":"10.1016\/j.jamda.2025.105855_bib15","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.neuropsychologia.2004.02.009","article-title":"Memory and executive function in older adults: relationships with temporal and prefrontal gray matter volumes and white matter hyperintensities","volume":"42","author":"Van Petten","year":"2004","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.jamda.2025.105855_bib16","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bandc.2010.11.008","article-title":"Correlation between gray\/white matter volume and cognition in healthy elderly people","volume":"75","author":"Taki","year":"2011","journal-title":"Brain Cogn"},{"key":"10.1016\/j.jamda.2025.105855_bib17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tins.2008.04.001","article-title":"White matter in learning, cognition and psychiatric disorders","volume":"31","author":"Fields","year":"2008","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jamda.2025.105855_bib18","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1152\/jn.00221.2016","article-title":"White matter and cognition: making the connection","volume":"116","author":"Filley","year":"2016","journal-title":"J Neurophysiol"},{"issue":"Pt 3","key":"10.1016\/j.jamda.2025.105855_bib19","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/brain\/awl377","article-title":"The topography of grey matter involvement in early and late onset Alzheimer's disease","volume":"130","author":"Frisoni","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.jamda.2025.105855_bib20","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1093\/cercor\/bhv105","article-title":"Altered gray matter structural covariance networks in early stages of Alzheimer's disease","volume":"26","author":"Montembeault","year":"2016","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.jamda.2025.105855_bib21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3389\/fneur.2019.00401","article-title":"Modifiable lifestyle factors and cognitive function in older people: a cross-sectional observational study","volume":"10","author":"Kimura","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.jamda.2025.105855_bib22","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.5719","article-title":"Association of modifiable lifestyle factors with cortical amyloid burden and cerebral glucose metabolism in older adults with mild cognitive impairment","volume":"3","author":"Kimura","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jamda.2025.105855_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0304-3940(01)02483-1","article-title":"Frequency-dependent spatial distribution of human somatosensory evoked neuromagnetic fields","volume":"318","author":"Hirata","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jamda.2025.105855_bib24","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3174\/ajnr.A2935","article-title":"Automatic voxel-based morphometry of structural MRI by SPM8 plus diffeomorphic anatomic registration through exponentiated lie algebra improves the diagnosis of probable Alzheimer disease","volume":"33","author":"Matsuda","year":"2012","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.jamda.2025.105855_bib25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/psyg.12370","article-title":"A comparative study: visual rating scores and the voxel-based specific regional analysis system for Alzheimer's disease on magnetic resonance imaging among subjects with Alzheimer's disease, mild cognitive impairment, and normal cognition","volume":"19","author":"Li","year":"2019","journal-title":"Psychogeriatrics"},{"key":"10.1016\/j.jamda.2025.105855_bib26","doi-asserted-by":"crossref","DOI":"10.1177\/0300060520917270","article-title":"Utility of VSRAD for diagnosing Alzheimer's disease in patients screened for dementia","volume":"48","author":"Oshikubo","year":"2020","journal-title":"J Int Med Res"},{"key":"10.1016\/j.jamda.2025.105855_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/jdi.13622","article-title":"Voxel-based specific regional analysis system for Alzheimer's disease utility as a screening tool for unrecognized cognitive dysfunction of elderly patients in diabetes outpatient clinics: multicenter retrospective exploratory study","volume":"13","author":"Ueba","year":"2022","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.jamda.2025.105855_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.arr.2016.01.003","article-title":"MRI morphometry in Alzheimer's disease","volume":"30","author":"Matsuda","year":"2016","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jamda.2025.105855_bib29","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/jnnp-2016-313476","article-title":"Association between naturally occurring anti-amyloid \u03b2 autoantibodies and medial temporal lobe atrophy in Alzheimer's disease","volume":"88","author":"Kimura","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jamda.2025.105855_bib30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.14336\/AD.2017.0818","article-title":"Voxel-based specific regional analysis system for Alzheimer's disease (VSRAD) on 3-tesla normal database: diagnostic accuracy in two independent cohorts with early alzheimer's disease","volume":"9","author":"Sone","year":"2018","journal-title":"Aging Dis"},{"key":"10.1016\/j.jamda.2025.105855_bib31","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.apmr.2011.07.195","article-title":"The association between decline in physical functioning and atrophy of medial temporal areas in community-dwelling older adults with amnestic and nonamnestic mild cognitive impairment","volume":"92","author":"Makizako","year":"2011","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.jamda.2025.105855_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.xkme.2022.100593","article-title":"CKD, brain atrophy, and white matter lesion volume: the Japan prospective studies collaboration for aging and dementia","volume":"5","author":"Maki","year":"2023","journal-title":"Kidney Med"},{"key":"10.1016\/j.jamda.2025.105855_bib33","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1007\/s10072-023-06854-1","article-title":"Association of smoking with brain gray and white matter volume: a Mendelian randomization study","volume":"44","author":"Lin","year":"2023","journal-title":"Neurol Sci"},{"key":"10.1016\/j.jamda.2025.105855_bib34","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1093\/gerona\/glac150","article-title":"Objective physical activity accumulation and brain volume in older adults: an MRI and whole-brain volume study","volume":"78","author":"Melo Neves","year":"2023","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jamda.2025.105855_bib35","first-page":"709","article-title":"Geriatric depression scale","volume":"24","author":"Yesavage","year":"1988","journal-title":"Psychopharmacol Bull"},{"issue":"Suppl 2","key":"10.1016\/j.jamda.2025.105855_bib36","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.neurobiolaging.2014.03.034","article-title":"Physical activity, fitness, and gray matter volume","volume":"35","author":"Erickson","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jamda.2025.105855_bib37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1613\/jair.953","article-title":"SMOTE: synthetic minority over-sampling technique","volume":"16","author":"Chawla","year":"2002","journal-title":"J Artif Intell Res"},{"key":"10.1016\/j.jamda.2025.105855_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-78519-8","article-title":"Robust diabetic prediction using ensemble machine learning models with synthetic minority over-sampling technique","volume":"14","author":"Sampath","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jamda.2025.105855_bib39","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1440-1789.2007.00794.x","article-title":"The role of neuroimaging in mild cognitive impairment","volume":"27","author":"Matsuda","year":"2007","journal-title":"Neuropathology"},{"key":"10.1016\/j.jamda.2025.105855_bib40","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1097\/JTO.0b013e3181ec173d","article-title":"Receiver operating characteristic curve in diagnostic test assessment","volume":"5","author":"Mandrekar","year":"2010","journal-title":"J Thorac Oncol"}],"container-title":["Journal of the American Medical Directors Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152586102500372X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152586102500372X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:35:05Z","timestamp":1779780905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152586102500372X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S152586102500372X"],"URL":"https:\/\/doi.org\/10.1016\/j.jamda.2025.105855","relation":{},"ISSN":["1525-8610"],"issn-type":[{"value":"1525-8610","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relative Hypothermia and Gray Matter Atrophy in Older Adults: A Cross-Sectional Study","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Medical Directors Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jamda.2025.105855","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Post-Acute and Long-Term Care Medical Association.","name":"copyright","label":"Copyright"}],"article-number":"105855"}}