{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:06:08Z","timestamp":1775819168953,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR-2016-02361123"],"award-info":[{"award-number":["GR-2016-02361123"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["andjrnl.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the Academy of Nutrition and Dietetics"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jand.2023.07.008","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T12:08:21Z","timestamp":1689595701000},"page":"1772-1780","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prebiotics and the Risk of Upper Digestive Tract and Stomach Cancers: The PrebiotiCa Study"],"prefix":"10.1016","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5841-5773","authenticated-orcid":false,"given":"Federica","family":"Turati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6777-2924","authenticated-orcid":false,"given":"Federica","family":"Concina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Bertuccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Fiori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1309-4467","authenticated-orcid":false,"given":"Maria","family":"Parpinel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Garavello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Crispo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Libra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Negri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Serraino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jand.2023.07.008_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/nrgastro.2015.47","article-title":"Towards a more comprehensive concept for prebiotics","volume":"12","author":"Bindels","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.jand.2023.07.008_bib2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.jand.2023.07.008_bib3","doi-asserted-by":"crossref","first-page":"nzy005","DOI":"10.1093\/cdn\/nzy005","article-title":"Health effects and sources of prebiotic dietary fiber","volume":"2","author":"Carlson","year":"2018","journal-title":"Curr Dev Nutr"},{"key":"10.1016\/j.jand.2023.07.008_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev-food-081315-032749","article-title":"A\u00a0critical look at prebiotics within the dietary fiber concept","volume":"7","author":"Verspreet","year":"2016","journal-title":"Annu Rev Food Sci Technol"},{"key":"10.1016\/j.jand.2023.07.008_bib5","article-title":"Role of microbiota-derived short-chain fatty acids in cancer development and prevention","volume":"139","author":"Mirzaei","year":"2021","journal-title":"Biomed Pharmacother"},{"issue":"7","key":"10.1016\/j.jand.2023.07.008_bib6","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.4161\/cbt.6.7.4318","article-title":"Short-chain fatty acid modulation of apoptosis in the Kato III human gastric carcinoma cell line","volume":"6","author":"Matthews","year":"2007","journal-title":"Cancer Biol Ther"},{"issue":"9","key":"10.1016\/j.jand.2023.07.008_bib7","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1002\/ijc.32162","article-title":"Fiber intake and the risk of head and neck cancer in the prostate, lung, colorectal and ovarian (PLCO) cohort","volume":"145","author":"Kawakita","year":"2019","journal-title":"Int J Cancer"},{"issue":"9","key":"10.1016\/j.jand.2023.07.008_bib8","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/ijc.30886","article-title":"Dietary fiber intake and head and neck cancer risk: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium","volume":"141","author":"Kawakita","year":"2017","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.jand.2023.07.008_bib9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ijc.10341","article-title":"Dietary risk factors for upper aerodigestive tract cancers","volume":"99","author":"Kasum","year":"2002","journal-title":"Int J Cancer"},{"issue":"13","key":"10.1016\/j.jand.2023.07.008_bib10","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1080\/10408398.2015.1067596","article-title":"Dietary fiber intake reduces risk for Barrett's esophagus and esophageal cancer","volume":"57","author":"Sun","year":"2017","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"10.1016\/j.jand.2023.07.008_bib11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.gastro.2013.04.001","article-title":"Dietary fiber intake reduces risk for gastric cancer: a meta-analysis","volume":"145","author":"Zhang","year":"2013","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jand.2023.07.008_bib12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12937-021-00667-8","article-title":"Dietary fiber intake from fresh and preserved food and risk of nasopharyngeal carcinoma: observational evidence from a Chinese population","volume":"20","author":"Mai","year":"2021","journal-title":"Nutr J"},{"issue":"16","key":"10.1016\/j.jand.2023.07.008_bib13","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1021\/jf070623x","article-title":"Fructan and free fructose content of common Australian vegetables and fruit","volume":"55","author":"Muir","year":"2007","journal-title":"J\u00a0Agric Food Chem"},{"issue":"2","key":"10.1016\/j.jand.2023.07.008_bib14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-277X.2010.01139.x","article-title":"Quantification of fructans, galacto-oligosacharides and other short-chain carbohydrates in processed grains and cereals","volume":"24","author":"Biesiekierski","year":"2011","journal-title":"J\u00a0Hum Nutr Diet"},{"issue":"7 Suppl","key":"10.1016\/j.jand.2023.07.008_bib15","first-page":"1407S","article-title":"Presence of inulin and oligofructose in the diets of Americans","volume":"129","author":"Moshfegh","year":"1999","journal-title":"J\u00a0Nutr"},{"issue":"8","key":"10.1016\/j.jand.2023.07.008_bib16","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1021\/jf970087g","article-title":"Selected fructooligosaccharide (1-kestose, nystose, and 1F-\u03b2-fructofuranosylnystose) composition of foods and feeds","volume":"45","author":"Campbell","year":"1997","journal-title":"J\u00a0Agric Food Chem"},{"issue":"11","key":"10.1016\/j.jand.2023.07.008_bib17","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/ecco-jcc\/jjv136","article-title":"Dietary intake of inulin-type fructans in active and inactive Crohn's disease and healthy controls: a case-control study","volume":"9","author":"Anderson","year":"2015","journal-title":"J\u00a0Crohns Colitis"},{"issue":"6","key":"10.1016\/j.jand.2023.07.008_bib18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/10408399509527714","article-title":"On the presence of inulin and oligofructose as natural ingredients in the Western diet","volume":"35","author":"van Loo","year":"1995","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"16","key":"10.1016\/j.jand.2023.07.008_bib19","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/0959-8049(93)90225-5","article-title":"Reproducibility of an Italian food frequency questionnaire for cancer studies: results for specific food items","volume":"29A","author":"Franceschi","year":"1993","journal-title":"Eur J Cancer"},{"issue":"2","key":"10.1016\/j.jand.2023.07.008_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/1047-2797(95)00129-8","article-title":"Validation of a food-frequency questionnaire to assess dietary intakes in cancer studies in Italy. Results for specific nutrients","volume":"6","author":"Decarli","year":"1996","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.jand.2023.07.008_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.oraloncology.2016.11.012","article-title":"Adherence to the World Cancer Research Fund\/American Institute for Cancer Research recommendations and head and neck cancers risk","volume":"64","author":"Bravi","year":"2017","journal-title":"Oral Oncol"},{"issue":"2","key":"10.1016\/j.jand.2023.07.008_bib22","first-page":"89","article-title":"Adherence to the Mediterranean diet and nasopharyngeal cancer risk in Italy","volume":"28","author":"Turati","year":"2017","journal-title":"Cancer Causes Control"},{"issue":"2","key":"10.1016\/j.jand.2023.07.008_bib23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/1097-0215(20000715)87:2<289::AID-IJC22>3.0.CO;2-9","article-title":"Food groups and risk of squamous cell esophageal cancer in northern Italy","volume":"87","author":"Bosetti","year":"2000","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.jand.2023.07.008_bib24","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/annonc\/mdn536","article-title":"Dietary intake of selected micronutrients and gastric cancer risk: an Italian case-control study","volume":"20","author":"Pelucchi","year":"2009","journal-title":"Ann Oncol"},{"issue":"5","key":"10.1016\/j.jand.2023.07.008_bib25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/01635580802054512","article-title":"Food groups and alcoholic beverages and the risk of stomach cancer: a case-control study in Italy","volume":"60","author":"Lucenteforte","year":"2008","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.jand.2023.07.008_bib26","series-title":"Banca di composizione degli alimenti per studi epidemiologici in Italia","author":"Salvini","year":"1998"},{"issue":"3-4","key":"10.1016\/j.jand.2023.07.008_bib27","first-page":"502","article-title":"The update of the of the Italian food composition database","volume":"17","author":"Gnagnarella","year":"2004","journal-title":"J\u00a0Food Comp Anal"},{"issue":"3","key":"10.1016\/j.jand.2023.07.008_bib28","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.foodchem.2008.05.112","article-title":"Food composition databases: the EuroFIR approach to develop tools to assure the quality of the data compilation process","volume":"113","author":"Westenbrink","year":"2009","journal-title":"Food Chem"},{"key":"10.1016\/j.jand.2023.07.008_bib29","article-title":"Quantification of naturally occurring prebiotic fiber in Italian foods","volume":"112","author":"Fiori","year":"2022","journal-title":"J\u00a0Food Comp Anal"},{"issue":"11","key":"10.1016\/j.jand.2023.07.008_bib30","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1158\/1055-9965.EPI-09-0782","article-title":"Nutrient dietary patterns and gastric cancer risk in Italy","volume":"18","author":"Bertuccio","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"26","key":"10.1016\/j.jand.2023.07.008_bib31","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa025039","article-title":"Adherence to a Mediterranean diet and survival in a Greek population","volume":"348","author":"Trichopoulou","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jand.2023.07.008_bib32","unstructured":"SAS. Version 9.4. SAS Institute Inc; Cary, NC, USA. www.sas.com"},{"issue":"1","key":"10.1016\/j.jand.2023.07.008_bib33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00394-022-02984-y","article-title":"Association of prebiotic fiber intake with colorectal cancer risk: the PrebiotiCa study","volume":"62","author":"Turati","year":"2023","journal-title":"Eur J Nutr"},{"issue":"2","key":"10.1016\/j.jand.2023.07.008_bib34","first-page":"977","article-title":"Intake of prebiotic fibers and the risk of laryngeal cancer: the PrebiotiCa study","volume":"62","author":"Turati","year":"2023","journal-title":"Eur J Nutr"},{"issue":"12","key":"10.1016\/j.jand.2023.07.008_bib35","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1017\/S1368980009005035","article-title":"The Italian National Food Consumption Survey INRAN-SCAI 2005-06: main results in terms of food consumption","volume":"12","author":"Leclercq","year":"2009","journal-title":"Public Health Nutr"},{"issue":"9","key":"10.1016\/j.jand.2023.07.008_bib36","first-page":"1605","article-title":"Legume intake and the risk of cancer: a multisite case-control study in Uruguay","volume":"20","author":"Aune","year":"2009","journal-title":"Cancer Causes Control"},{"issue":"6","key":"10.1016\/j.jand.2023.07.008_bib37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/CEJ.0000000000000371","article-title":"Adherence to Mediterranean diet and risk of gastric cancer: results of a case-control study in Italy","volume":"26","author":"Stojanovic","year":"2017","journal-title":"Eur J Cancer Prev"},{"issue":"1","key":"10.1016\/j.jand.2023.07.008_bib38","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12937-020-00556-6","article-title":"Association of whole grains intake and the risk of digestive tract cancer: a systematic review and meta-analysis","volume":"19","author":"Zhang","year":"2020","journal-title":"Nutr J"},{"issue":"1","key":"10.1016\/j.jand.2023.07.008_bib39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1368-8375(98)00060-8","article-title":"Diet and risk of cancer of the upper aerodigestive tract\u2014I. Foods","volume":"35","author":"De Stefani","year":"1999","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.jand.2023.07.008_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1079\/PNS2002235","article-title":"Session: whole cereal grains, fibre and human cancer wholegrain cereals and cancer in Italy","volume":"62","author":"La Vecchia","year":"2003","journal-title":"Proc Nutr Soc"},{"issue":"5","key":"10.1016\/j.jand.2023.07.008_bib41","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/CEJ.0000000000000277","article-title":"Association between Mediterranean diet and head and neck cancer: results of a large case-control study in Italy","volume":"26","author":"Giraldi","year":"2017","journal-title":"Eur J Cancer Prev"},{"issue":"12","key":"10.1016\/j.jand.2023.07.008_bib42","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.3390\/nu12123756","article-title":"Whole grains, refined grains, and cancer risk: a systematic review of meta-analyses of observational studies","volume":"12","author":"Gaesser","year":"2020","journal-title":"Nutrients"},{"issue":"3 Supple","key":"10.1016\/j.jand.2023.07.008_bib43","doi-asserted-by":"crossref","first-page":"439S","DOI":"10.1093\/ajcn\/70.3.439s","article-title":"Legumes and soybeans: overview of their nutritional profiles and health effects","volume":"70","author":"Messina","year":"1999","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.jand.2023.07.008_bib44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/oxfordjournals.aje.a114366","article-title":"Total energy intake: implications for epidemiologic analyses","volume":"124","author":"Willett","year":"1986","journal-title":"Am J Epidemiol"}],"container-title":["Journal of the Academy of Nutrition and Dietetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212267223012753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2212267223012753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T20:34:46Z","timestamp":1761942886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2212267223012753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S2212267223012753"],"URL":"https:\/\/doi.org\/10.1016\/j.jand.2023.07.008","relation":{},"ISSN":["2212-2672"],"issn-type":[{"value":"2212-2672","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prebiotics and the Risk of Upper Digestive Tract and Stomach Cancers: The PrebiotiCa Study","name":"articletitle","label":"Article Title"},{"value":"Journal of the Academy of Nutrition and Dietetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jand.2023.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the Academy of Nutrition and Dietetics.","name":"copyright","label":"Copyright"}]}}