{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T03:53:41Z","timestamp":1780804421965,"version":"3.54.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA016520"],"award-info":[{"award-number":["P30 CA016520"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017006","name":"Abramson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","japha.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Pharmacists Association"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.japh.2025.102990","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T02:59:45Z","timestamp":1762570785000},"page":"102990","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patient and provider perspectives on the implementation of DPYD testing in oncology care clinics in an academic health system"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4886-2171","authenticated-orcid":false,"given":"Victoria","family":"Wittner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9133-7467","authenticated-orcid":false,"given":"Jasmine","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5345-6154","authenticated-orcid":false,"given":"Mari","family":"Cayabyab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7199-2196","authenticated-orcid":false,"given":"Glenda","family":"Hoffecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Kalman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursina","family":"Teitelbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4089-856X","authenticated-orcid":false,"given":"Robert","family":"Schnoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine A.","family":"Rendle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-3289","authenticated-orcid":false,"given":"Sony","family":"Tuteja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2D","key":"10.1016\/j.japh.2025.102990_bib1","doi-asserted-by":"crossref","DOI":"10.6004\/jnccn.2024.0029","article-title":"Colon cancer, version 3.2024, NCCN clinical practice guidelines in oncology","volume":"22","author":"Benson","year":"2024","journal-title":"J Natl Compr Canc Netw"},{"issue":"4","key":"10.1016\/j.japh.2025.102990_bib2","doi-asserted-by":"crossref","first-page":"439","DOI":"10.6004\/jnccn.2021.0017","article-title":"Pancreatic adenocarcinoma, version 2.2021, NCCN clinical practice guidelines in oncology","volume":"19","author":"Tempero","year":"2021","journal-title":"J Natl Compr Canc Netw"},{"issue":"5","key":"10.1016\/j.japh.2025.102990_bib3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.6004\/jnccn.2024.0035","article-title":"Breast cancer, version 3.2024, NCCN clinical practice guidelines in oncology","volume":"22","author":"Gradishar","year":"2024","journal-title":"J Natl Compr Canc Netw"},{"issue":"2","key":"10.1016\/j.japh.2025.102990_bib4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.6004\/jnccn.2025.0007","article-title":"NCCN guidelines\u00ae insights: head and neck cancers, version 2.2025: featured updates to the NCCN guidelines","volume":"23","author":"Colevas","year":"2025","journal-title":"J Natl Compr Canc Netw"},{"issue":"12","key":"10.1016\/j.japh.2025.102990_bib5","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/onco.13967","article-title":"Pathogenic DPYD variants and treatment-related mortality in patients receiving fluoropyrimidine chemotherapy: a systematic review and meta-analysis","volume":"26","author":"Sharma","year":"2021","journal-title":"Oncologist"},{"issue":"8","key":"10.1016\/j.japh.2025.102990_bib6","doi-asserted-by":"crossref","DOI":"10.1200\/PO.23.00623","article-title":"Real-world impact of an in-house dihydropyrimidine dehydrogenase (DPYD) genotype test on fluoropyrimidine dosing, toxicities, and hospitalizations at a multisite cancer center","volume":"22","author":"Nguyen","year":"2024","journal-title":"JCO Precis Oncol"},{"issue":"2","key":"10.1016\/j.japh.2025.102990_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/cts.13704","article-title":"Real-world implementation of DPYD and UGT1A1 pharmacogenetic testing in a community-based cancer center","volume":"17","author":"Muldoon","year":"2024","journal-title":"Clin Translational Sci"},{"issue":"11","key":"10.1016\/j.japh.2025.102990_bib8","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S1470-2045(18)30686-7","article-title":"DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis","volume":"19","author":"Henricks","year":"2018","journal-title":"Lancet Oncol"},{"issue":"18","key":"10.1016\/j.japh.2025.102990_bib9","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1002\/cncr.30766","article-title":"North Central Cancer Treatment Group N0543 (Alliance): a phase 2 trial of pharmacogenetic-based dosing of irinotecan, oxaliplatin, and capecitabine as first-line therapy for patients with advanced small bowel adenocarcinoma","volume":"123","author":"McWilliams","year":"2017","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.japh.2025.102990_bib10","first-page":"497","article-title":"Strategies for DPYD testing prior to fluoropyrimidine chemotherapy in the US","volume":"32","author":"Tracksdorf","year":"2024","journal-title":"Support Care Cancer"},{"issue":"19","key":"10.1016\/j.japh.2025.102990_bib11","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1093\/ajhp\/zxad117","article-title":"Addressing barriers to increased adoption of DPYD genotyping at a large multisite cancer center","volume":"80","author":"Morris","year":"2023","journal-title":"Am J Health-System Pharm"},{"issue":"1","key":"10.1016\/j.japh.2025.102990_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12885-022-09171-6","article-title":"Preemptive pharmacogenetic testing to guide chemotherapy dosing in patients with gastrointestinal malignancies: a qualitative study of barriers to implementation","volume":"22","author":"Lau-Min","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.japh.2025.102990_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.859846","article-title":"Implementing pharmacogenetic testing in gastrointestinal cancers (IMPACT-GI): study protocol for a pragmatic implementation trial for establishing DPYD and UGT1A1 screening to guide chemotherapy dosing","volume":"12","author":"Varughese","year":"2022","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.japh.2025.102990_bib14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s10488-010-0327-7","article-title":"Advancing a conceptual model of evidence-based practice implementation in public service sectors","volume":"38","author":"Aarons","year":"2011","journal-title":"Adm Policy Ment Health"},{"issue":"9","key":"10.1016\/j.japh.2025.102990_bib15","doi-asserted-by":"crossref","DOI":"10.1200\/PO-25-00086","article-title":"Implementation of DPYD and UGT1A1 testing in patients with GI cancer: a prospective, nonrandomized clinical trial","author":"Tuteja","year":"2025","journal-title":"JCO Precis Oncol"},{"key":"10.1016\/j.japh.2025.102990_bib18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1748-5908-4-50","article-title":"Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science","volume":"4","author":"Damschroder","year":"2009","journal-title":"Implement Sci"},{"issue":"1","key":"10.1016\/j.japh.2025.102990_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13012-024-01397-1","article-title":"Planning for and Assessing Rigor in Rapid Qualitative Analysis (PARRQA): a consensus-based framework for designing, conducting, and reporting","volume":"19","author":"Kowalski","year":"2024","journal-title":"Implement Sci"},{"issue":"1","key":"10.1016\/j.japh.2025.102990_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13012-021-01111-5","article-title":"Rapid versus traditional qualitative analysis using the Consolidated Framework for Implementation Research (CFIR)","volume":"16","author":"Nevedal","year":"2021","journal-title":"Implementation Sci"},{"issue":"1","key":"10.1016\/j.japh.2025.102990_bib21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13012-022-01245-0","article-title":"The updated Consolidated Framework for Implementation Research based on user feedback","volume":"17","author":"Damschroder","year":"2022","journal-title":"Implementation Sci"},{"issue":"01","key":"10.1016\/j.japh.2025.102990_bib22","doi-asserted-by":"crossref","first-page":"001","DOI":"10.1055\/s-0039-3402715","article-title":"Reducing alert burden in electronic health records: state of the art recommendations from four health systems","volume":"11","author":"McGreevey","year":"2020","journal-title":"Appl Clin Inform"},{"issue":"6","key":"10.1016\/j.japh.2025.102990_bib23","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2115126119","article-title":"A 680,000-person megastudy of nudges to encourage vaccination in pharmacies","volume":"119","author":"Milkman","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.japh.2025.102990_bib24","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.0818","article-title":"Effect of an automated patient dashboard using active choice and peer comparison performance feedback to physicians on statin prescribing: the PRESCRIBE cluster randomized clinical trial","volume":"1","author":"Patel","year":"2018","journal-title":"JAMA Netw Open"},{"issue":"28","key":"10.1016\/j.japh.2025.102990_bib25","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1200\/JCO.23.00355","article-title":"Cluster randomized pragmatic clinical trial testing behavioral economic implementation strategies to improve tobacco treatment for patients with cancer who smoke","volume":"41","author":"Jenssen","year":"2023","journal-title":"JCO"},{"issue":"10","key":"10.1016\/j.japh.2025.102990_bib26","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1111\/jgs.19609","article-title":"Comparing fourteen behavioral science electronic health record deprescribing tools in older adults: NUDGE-EHR adaptive trial","volume":"73","author":"Lauffenburger","year":"2025","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.japh.2025.102990_bib27","author":"Zarkhin"},{"key":"10.1016\/j.japh.2025.102990_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.pec.2023.107904","article-title":"Patient understanding of pharmacogenomic test results in clinical care","volume":"115","author":"Doyle","year":"2023","journal-title":"Patient Educ Couns"},{"key":"10.1016\/j.japh.2025.102990_bib29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s40142-014-0037-7","article-title":"The critical challenge of educating the public about genetics","volume":"2","author":"Dougherty","year":"2014","journal-title":"Curr Genet Med Rep"},{"issue":"12","key":"10.1016\/j.japh.2025.102990_bib30","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.ajhg.2022.11.005","article-title":"Understanding changes in genetic literacy over time and in genetic research participants","volume":"109","author":"Little","year":"2022","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/j.japh.2025.102990_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/tpj.2016.72","article-title":"Are patients willing to incur out-of-pocket costs for pharmacogenomic testing?","volume":"17","author":"Bielinski","year":"2017","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.japh.2025.102990_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1384667","article-title":"Estimating preferences and willingness to pay for pharmacogenetic testing in populations who are medically underserved: a discrete choice experiment","volume":"15","author":"Gawronski","year":"2024","journal-title":"Front Pharmacol"},{"issue":"5","key":"10.1016\/j.japh.2025.102990_bib34","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/s41436-021-01117-w","article-title":"Expanding evidence leads to new pharmacogenomics payer coverage","volume":"23","author":"Empey","year":"2021","journal-title":"Genet Med"}],"container-title":["Journal of the American Pharmacists Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1544319125006697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1544319125006697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:48:11Z","timestamp":1771508891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1544319125006697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1544319125006697"],"URL":"https:\/\/doi.org\/10.1016\/j.japh.2025.102990","relation":{},"ISSN":["1544-3191"],"issn-type":[{"value":"1544-3191","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patient and provider perspectives on the implementation of DPYD testing in oncology care clinics in an academic health system","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Pharmacists Association","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.japh.2025.102990","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the American Pharmacists Association\u00ae.","name":"copyright","label":"Copyright"}],"article-number":"102990"}}