{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:20:30Z","timestamp":1792826430016,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jare.2018.05.007","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T10:39:02Z","timestamp":1531910342000},"page":"111-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Clinical characteristics and effective treatments of scrub typhus-associated hemophagocytic lymphohistiocytosis in children"],"prefix":"10.1016","volume":"15","author":[{"given":"Yi-Mei","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Shi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Rong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7181-4368","authenticated-orcid":false,"given":"Ai-Hua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jare.2018.05.007_b0005","doi-asserted-by":"crossref","first-page":"e63668","DOI":"10.1371\/journal.pone.0063668","article-title":"A case-control study of risk factors associated with scrub typhus infection in Beijing, China","volume":"8","author":"Lyu","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jare.2018.05.007_b0010","first-page":"170","article-title":"Approaches to vaccines against Orientia tsutsugamushi","volume":"2","author":"Valbuena","year":"2012","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"10.1016\/j.jare.2018.05.007_b0015","doi-asserted-by":"crossref","first-page":"368","DOI":"10.4103\/0255-0857.90166","article-title":"A rapid, sensitive and reliable diagnostic test for scrub typhus in China","volume":"29","author":"Lijuan","year":"2011","journal-title":"Indian J Med Microbiol"},{"issue":"3","key":"10.1016\/j.jare.2018.05.007_b0020","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijid.2008.07.020","article-title":"The difference in clinical characteristics between acute Q fever and scrub typhus in southern Taiwan","volume":"13","author":"Lai","year":"2009","journal-title":"Int J Infect Dis"},{"issue":"3","key":"10.1016\/j.jare.2018.05.007_b0025","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/PCC.0b013e318198868b","article-title":"An unusual cause of multiple organ dysfunction syndrome in the pediatric intensive care unit: hemophagocytic lymphohistiocytosis","volume":"10","author":"Karapinar","year":"2009","journal-title":"Pediatr Crit Care Med"},{"issue":"3","key":"10.1016\/j.jare.2018.05.007_b0030","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s12288-012-0210-7","article-title":"Hemophagocytic lymphohistiocytosis","volume":"30","author":"Narendra","year":"2014","journal-title":"Indian J Hematol Blood Transfus"},{"issue":"Pt 4","key":"10.1016\/j.jare.2018.05.007_b0035","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1099\/jmm.0.025833-0","article-title":"Haemophagocytic syndrome and rickettsial diseases","volume":"60","author":"Cascio","year":"2011","journal-title":"J Med Microbiol"},{"issue":"10","key":"10.1016\/j.jare.2018.05.007_b0040","first-page":"1324","article-title":"Secondary hemophagocytic lymphohistiocytosis in zoonoses. A systematic review","volume":"16","author":"Cascio","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.jare.2018.05.007_b0045","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1258\/td.2010.100303","article-title":"Rickettsial infection with hemophagocytosis","volume":"41","author":"Jayakrishnan","year":"2011","journal-title":"Trop Doct"},{"issue":"1","key":"10.1016\/j.jare.2018.05.007_b0050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/tropej\/fms030","article-title":"Life-threatening scrub typhus with hemophagocytosis and acute respiratory distress syndrome in an infant","volume":"59","author":"Kwon","year":"2013","journal-title":"J Trop Pediatr"},{"issue":"1","key":"10.1016\/j.jare.2018.05.007_b0055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2149\/tmh.2012-07","article-title":"Pancreatitis and MODS due to scrub typhus and dengue co-infection","volume":"40","author":"Iqbal","year":"2012","journal-title":"Trop Med Health"},{"issue":"1","key":"10.1016\/j.jare.2018.05.007_b0060","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/0972-9062.130167","article-title":"Rare concurrent infection with scrub typhus, dengue and malaria in a young female","volume":"51","author":"Kumar","year":"2014","journal-title":"J Vector Borne Dis"},{"issue":"3","key":"10.1016\/j.jare.2018.05.007_b0065","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4269\/ajtmh.2007.77.525","article-title":"Coinfection with leptospirosis and scrub typhus in Taiwanese patients","volume":"77","author":"Lee","year":"2007","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"10.1016\/j.jare.2018.05.007_b0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/0049475513512640","article-title":"Scrub typhus and malaria co-infection causing severe sepsis","volume":"44","author":"Mahajan","year":"2014","journal-title":"Trop Doct"},{"issue":"1","key":"10.1016\/j.jare.2018.05.007_b0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4269\/ajtmh.2003.68.89","article-title":"Possible scrub typhus coinfections in Thai agricultural workers hospitalized with leptospirosis","volume":"68","author":"Watt","year":"2003","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"10.1016\/j.jare.2018.05.007_b0080","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1469-0691.2009.02865.x","article-title":"A serosurvey of Orientia tsutsugamushi from patients with scrub typhus","volume":"16","author":"Kim","year":"2010","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"10.1016\/j.jare.2018.05.007_b0085","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"10.1016\/j.jare.2018.05.007_b0090","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jiph.2011.11.001","article-title":"Scrub typhus in children at a tertiary hospital in southern India: clinical profile and complications","volume":"5","author":"Kumar","year":"2012","journal-title":"J Infect Public Health"},{"issue":"4","key":"10.1016\/j.jare.2018.05.007_b0095","first-page":"538","article-title":"Serological evidence of rickettsial infections in Delhi","volume":"135","author":"Mittal","year":"2012","journal-title":"Indian J Med Res"},{"issue":"11","key":"10.1016\/j.jare.2018.05.007_b0100","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s12098-012-0721-0","article-title":"Clinical profile of scrub typhus in children","volume":"79","author":"Palanivel","year":"2012","journal-title":"Indian J Pediatr"},{"issue":"2","key":"10.1016\/j.jare.2018.05.007_b0105","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s13312-010-0024-3","article-title":"Rickettsial infections: Indian perspective","volume":"47","author":"Rathi","year":"2010","journal-title":"Indian Pediatr"},{"issue":"10","key":"10.1016\/j.jare.2018.05.007_b0110","first-page":"775","article-title":"Clinical features of four atypical pediatric cases of endemic typhus with pneumonia","volume":"51","author":"Liu","year":"2013","journal-title":"Zhonghua Er Ke Za Zhi"},{"issue":"3","key":"10.1016\/j.jare.2018.05.007_b0115","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1089\/vbz.2012.1059","article-title":"Scrub typhus cases in a teaching hospital in Penghu, Taiwan, 2006\u20132010","volume":"13","author":"Wang","year":"2013","journal-title":"Vector Borne Zoonotic Dis"},{"key":"10.1016\/j.jare.2018.05.007_b0120","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/1471-2334-14-139","article-title":"Meteorological factors and risk of scrub typhus in Guangzhou, southern China, 2006\u20132012","volume":"14","author":"Li","year":"2014","journal-title":"BMC Infect Dis"},{"issue":"5","key":"10.1016\/j.jare.2018.05.007_b0125","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s11606-015-3371-x","article-title":"Scrub typhus (Tsutsugamushi Disease) presenting as fever with an eschar","volume":"31","author":"Shikino","year":"2016","journal-title":"J Gen Intern Med"},{"issue":"6","key":"10.1016\/j.jare.2018.05.007_b0130","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s12098-014-1664-4","article-title":"Scrub typhus: audit of an outbreak","volume":"82","author":"Krishna","year":"2015","journal-title":"Indian J Pediatr"},{"issue":"4","key":"10.1016\/j.jare.2018.05.007_b0135","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/pbc.22814","article-title":"Ehrlichia-induced hemophagocytic lymphohistiocytosis in two children","volume":"56","author":"Hanson","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.jare.2018.05.007_b0140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-2334-10-108","article-title":"Clinical and laboratory findings associated with severe scrub typhus","volume":"10","author":"Kim","year":"2010","journal-title":"BMC Infect Dis"},{"issue":"5","key":"10.1016\/j.jare.2018.05.007_b0145","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10157-012-0753-9","article-title":"Acute kidney injury in scrub typhus","volume":"17","author":"Attur","year":"2013","journal-title":"Clin Exp Nephrol"},{"issue":"4","key":"10.1016\/j.jare.2018.05.007_b0150","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4103\/0028-3886.185397","article-title":"Brain MRI findings in a patient with scrub typhus infection","volume":"64","author":"Neyaz","year":"2016","journal-title":"Neurol India"},{"issue":"7","key":"10.1016\/j.jare.2018.05.007_b0155","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4103\/0366-6999.228234","article-title":"Central nervous system involvement in hemophagocytic lymphohistiocytosis in adults: a retrospective analysis of 96 patients in a single center","volume":"131","author":"Song","year":"2018","journal-title":"Chin Med J (Engl)"},{"issue":"3","key":"10.1016\/j.jare.2018.05.007_b0160","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/pbc.21564","article-title":"The role of the initial bone marrow aspirate in the diagnosis of hemophagocytic lymphohistiocytosis","volume":"51","author":"Gupta","year":"2008","journal-title":"Pediatr Blood Cancer"},{"issue":"11","key":"10.1016\/j.jare.2018.05.007_b0165","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1001\/jama.1969.03160110017004","article-title":"Statewide study of chloramphenicol therapy and fatal aplastic anemia","volume":"208","author":"Wallerstein","year":"1969","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.jare.2018.05.007_b0170","first-page":"726","article-title":"Secondary hemophagocytic lymphohistiocytosis in adults: an update on diagnosis and therapy","volume":"10","author":"Kleynberg","year":"2012","journal-title":"Clin Adv Hematol Oncol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123218300626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123218300626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T20:45:10Z","timestamp":1761857110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123218300626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":34,"alternative-id":["S2090123218300626"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2018.05.007","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical characteristics and effective treatments of scrub typhus-associated hemophagocytic lymphohistiocytosis in children","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2018.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Production and hosting by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}