{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:33:04Z","timestamp":1791541984132,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T00:00:00Z","timestamp":1570320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M601922"],"award-info":[{"award-number":["2016M601922"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018T110577"],"award-info":[{"award-number":["2018T110577"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003512","name":"State Administration of Foreign Experts Affairs","doi-asserted-by":"publisher","award":["B18056"],"award-info":[{"award-number":["B18056"]}],"id":[{"id":"10.13039\/501100003512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20170736"],"award-info":[{"award-number":["BK20170736"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011360","name":"State Key Laboratory of Natural Medicines","doi-asserted-by":"publisher","award":["SKLNMKF201708"],"award-info":[{"award-number":["SKLNMKF201708"]}],"id":[{"id":"10.13039\/501100011360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018621","name":"Program for Changjiang Scholars and Innovative Research Team in University","doi-asserted-by":"publisher","award":["IRT_15R63"],"award-info":[{"award-number":["IRT_15R63"]}],"id":[{"id":"10.13039\/501100018621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970596"],"award-info":[{"award-number":["31970596"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81430092"],"award-info":[{"award-number":["81430092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703637"],"award-info":[{"award-number":["81703637"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jare.2019.10.003","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T01:54:16Z","timestamp":1570672456000},"page":"57-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Structure-based tailoring of the first coumarins-specific bergaptol O-methyltransferase to synthesize bergapten for depigmentation disorder treatment"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8962-5212","authenticated-orcid":false,"given":"Yucheng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanze","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanlong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3143-9756","authenticated-orcid":false,"given":"Zhixiong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyi","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2019.10.003_b0005","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1021\/acs.jmedchem.7b00967","article-title":"Inhibitors of melanogenesis: an updated review","volume":"61","author":"Pillaiyar","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.jare.2019.10.003_b0010","doi-asserted-by":"crossref","first-page":"9812","DOI":"10.1002\/anie.201704616","article-title":"Structure of human Tyrosinase related protein 1 reveals a binuclear zinc active site important for Melanogenesis","volume":"56","author":"Lai","year":"2017","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.jare.2019.10.003_b0015","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.3390\/ijms19041108","article-title":"Sesamol inhibited Melanogenesis by regulating melanin-related signal transduction in B16F10 cells","volume":"19","author":"Wu","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2019.10.003_b0020","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.bioorg.2018.09.003","article-title":"Inhibitory properties of aromatic Thiosemicarbazones on mushroom Tyrosinase: synthesis, kinetic studies, molecular docking and effectiveness in melanogenesis inhibition","volume":"81","author":"Ha\u0142dys","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.jare.2019.10.003_b0025","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.3390\/ijms19123994","article-title":"Melanogenesis inhibitors from the Rhizoma of Ligusticum Sinense in B16\u2013F10 melanoma cells in vitro and Zebrafish in vivo","volume":"19","author":"Cheng","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2019.10.003_b0030","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2165\/00003495-199856040-00015","article-title":"5-methoxypsoralen: a review of its effects in psoriasis and vitiligo","volume":"56","author":"Mcneely","year":"1998","journal-title":"Drugs"},{"issue":"3","key":"10.1016\/j.jare.2019.10.003_b0035","first-page":"378","article-title":"Psoralen and bergapten: in silico metabolism and toxicophoric analysis of drugs used to treat vitiligo","volume":"12","author":"Da","year":"2009","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2019.10.003_b0040","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/jamadermatol.2017.0002","article-title":"Phototherapy for vitiligo: a systematic review and meta-analysis","volume":"153","author":"Bae","year":"2017","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jare.2019.10.003_b0045","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.seppur.2010.08.007","article-title":"Separation of minor coumarins from Peucedanum praeruptorum using HSCCC and preparative HPLC guided by HPLC\/MS","volume":"75","author":"Hou","year":"2010","journal-title":"Sep Purif Technol"},{"key":"10.1016\/j.jare.2019.10.003_b0050","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/0031-9422(95)00783-0","article-title":"Coumarins from Peucedanum praeruptorum","volume":"41","author":"Ling-Yi","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jare.2019.10.003_b0055","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.tibtech.2019.01.003","article-title":"Systems metabolic engineering strategies: integrating systems and synthetic biology with metabolic engineering","volume":"37","author":"Choi","year":"2019","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.jare.2019.10.003_b0060","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41589-019-0247-0","article-title":"Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy","volume":"15","author":"Dastmalchi","year":"2019","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.jare.2019.10.003_b0065","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1039\/C9NP00005D","article-title":"Cell factory engineering for improved production of natural products","volume":"36","author":"Nielsen","year":"2019","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.jare.2019.10.003_b0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13036-019-0174-3","article-title":"Elucidation of the biosynthesis pathway and heterologous construction of a sustainable route for producing umbelliferone","volume":"13","author":"Zhao","year":"2019","journal-title":"J Biol Eng"},{"key":"10.1016\/j.jare.2019.10.003_b0075","doi-asserted-by":"crossref","first-page":"996","DOI":"10.3389\/fpls.2015.00996","article-title":"Integration of a decrescent transcriptome and metabolomics dataset of Peucedanum praeruptorum to investigate the CYP450 and MDR genes involved in coumarins biosynthesis and transport","volume":"6","author":"Zhao","year":"2015","journal-title":"Front Plant Sci"},{"key":"10.1016\/j.jare.2019.10.003_b0080","first-page":"e2634v2631","article-title":"Defining and redefining its role in biology: Synthetic biology as an emerging field at the interface of engineering and biology","volume":"4","author":"Ng","year":"2016","journal-title":"PeerJ Preprints"},{"key":"10.1016\/j.jare.2019.10.003_b0085","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1074\/jbc.M109.036673","article-title":"Engineering monolignol 4-O-methyltransferases to modulate lignin biosynthesis","volume":"285","author":"Bhuiy","year":"2010","journal-title":"J. Bio. Chem."},{"key":"10.1016\/j.jare.2019.10.003_b0090","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1105\/tpc.112.101287","article-title":"An engineered monolignol 4-o-methyltransferase depresses lignin biosynthesis and confers novel metabolic capability in Arabidopsis","volume":"24","author":"Zhang","year":"2012","journal-title":"Plant Cell"},{"key":"10.1016\/j.jare.2019.10.003_b0095","doi-asserted-by":"crossref","first-page":"11275","DOI":"10.1073\/pnas.1816707116","article-title":"Consensus sequence design as a general strategy to create hyperstable, biologically active proteins","volume":"116","author":"Sternke","year":"2019","journal-title":"P Natl Acad Sci USA"},{"key":"10.1016\/j.jare.2019.10.003_b0100","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/s41467-019-08781-2","article-title":"Promiscuous enzymatic activity-aided multiple-pathway network design for metabolic flux rearrangement in hydroxytyrosol biosynthesis","volume":"10","author":"Chen","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2019.10.003_b0105","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fpls.2016.00722","article-title":"Cloning, functional characterization, and catalytic mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn","volume":"7","author":"Zhao","year":"2016","journal-title":"Front Plant Sci"},{"key":"10.1016\/j.jare.2019.10.003_b0110","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1107\/S0907444906019949","article-title":"HKL-3000: the integration of data reduction and structure solution\u2013from diffraction images to an initial model in minutes","volume":"62","author":"Minor","year":"2006","journal-title":"Acta Crystallogr D"},{"key":"10.1016\/j.jare.2019.10.003_b0115","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1107\/S0907444910045749","article-title":"Overview of the CCP4 suite and current developments","volume":"67","author":"Winn","year":"2011","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.jare.2019.10.003_b0120","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1105\/tpc.001412","article-title":"Structural basis for the modulation of lignin monomer methylation by caffeic acid\/5-hydroxyferulic acid 3\/5-O-methyltransferase","volume":"14","author":"Zubieta","year":"2002","journal-title":"Plant Cell"},{"key":"10.1016\/j.jare.2019.10.003_b0125","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1107\/S0907444902016657","article-title":"PHENIX: building new software for automated crystallographic structure determination","volume":"58","author":"Adams","year":"2002","journal-title":"Acta Crystallogr D"},{"key":"10.1016\/j.jare.2019.10.003_b0130","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr D"},{"key":"10.1016\/j.jare.2019.10.003_b0135","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.3390\/ijms20071533","article-title":"The molecular and structural basis of O-methylation reaction in Coumarin Biosynthesis in Peucedanum praeruptorum Dunn","volume":"20","author":"Zhao","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2019.10.003_b0140","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","article-title":"Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments","volume":"27","author":"Sastry","year":"2013","journal-title":"J Comput Aid Mol Des"},{"key":"10.1016\/j.jare.2019.10.003_b0145","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","article-title":"Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes","volume":"49","author":"Friesner","year":"2006","journal-title":"J Med Chem"},{"key":"10.1016\/j.jare.2019.10.003_b0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1747-0285.2005.00327.x","article-title":"Use of an induced fit receptor structure in virtual screening","volume":"67","author":"Sherman","year":"2006","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.jare.2019.10.003_b0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.0022-202x.2001.01377.x","article-title":"A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages","volume":"117","author":"Muller-Rover","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jare.2019.10.003_b0160","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev Dynam"},{"issue":"12","key":"10.1016\/j.jare.2019.10.003_b0165","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.phytochem.2006.05.008","article-title":"Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells","volume":"67","author":"Lee","year":"2006","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jare.2019.10.003_b0170","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.4155\/fmc-2018-0375","article-title":"Translational role of natural coumarins and their derivatives as anticancer agents","volume":"11","author":"Menezes","year":"2019","journal-title":"Future Med Chem"},{"key":"10.1016\/j.jare.2019.10.003_b0175","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/j.1432-1033.2004.03995.x","article-title":"Furanocoumarin biosynthesis in Ammi majus L","volume":"271","author":"Hehmann","year":"2004","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jare.2019.10.003_b0180","first-page":"197","article-title":"Molecular cloning and functional analysis of bergaptol-O-methyltransferase from Angelica dahurica (Bai Zhi) and using it to efficiently produce bergapten in E. coli","volume":"53","author":"Lo","year":"2012","journal-title":"Bot Stud"},{"key":"10.1016\/j.jare.2019.10.003_b0185","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00299-008-0631-9","article-title":"Constitutive expression of bergaptol O-methyltransferase in Glehnia littoralis cell cultures","volume":"28","author":"Ishikawa","year":"2009","journal-title":"Plant Cell Rep"},{"key":"10.1016\/j.jare.2019.10.003_b0190","doi-asserted-by":"crossref","first-page":"e1006636","DOI":"10.1371\/journal.pgen.1006636","article-title":"TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF","volume":"13","author":"Seberg","year":"2017","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jare.2019.10.003_b0195","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.puhe.2017.11.016","article-title":"Skin-lightening practices among female high school students in Ghana","volume":"155","author":"Osei","year":"2018","journal-title":"Public Health"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123219301614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123219301614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T20:46:33Z","timestamp":1761857193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123219301614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":39,"alternative-id":["S2090123219301614"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2019.10.003","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure-based tailoring of the first coumarins-specific bergaptol O-methyltransferase to synthesize bergapten for depigmentation disorder treatment","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2019.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}