{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:38:34Z","timestamp":1793500714842,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,22]],"date-time":"2020-03-22T00:00:00Z","timestamp":1584835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010653","name":"Masaryk University","doi-asserted-by":"publisher","award":["MUNI\/A\/0947\/2019"],"award-info":[{"award-number":["MUNI\/A\/0947\/2019"]}],"id":[{"id":"10.13039\/501100010653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jare.2020.03.007","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T02:47:00Z","timestamp":1585018020000},"page":"71-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":110,"special_numbering":"C","title":["Possible synergy effect of hydrogen sulfide and acetate produced by sulfate-reducing bacteria on inflammatory bowel disease development"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8450-7137","authenticated-orcid":false,"given":"Ivan","family":"Kushkevych","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani","family":"Dordevi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"V\u00edt\u011bzov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2020.03.007_b0005","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1574-6941.2002.tb00942.x","article-title":"Sulphate-reducing bacteria in human feces and their association with inflammatory diseases","volume":"40","author":"Loubinoux","year":"2002","journal-title":"FEMS Microbiol Ecol"},{"key":"10.1016\/j.jare.2020.03.007_b0010","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1515\/med-2018-0052","article-title":"Metabolic activity of sulfate-reducing bacteria from rodents with colitis","volume":"13","author":"Kov\u00e1\u010d","year":"2018","journal-title":"Open Med"},{"key":"10.1016\/j.jare.2020.03.007_b0015","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2754\/avb201786040405","article-title":"Kinetic properties of growth of intestinal sulphate-reducing bacteria isolated from healthy mice and mice with ulcerative colitis","volume":"86","author":"Kushkevych","year":"2017","journal-title":"Acta Vet Brno"},{"key":"10.1016\/j.jare.2020.03.007_b0020","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1574-6968.1991.tb04799.x","article-title":"Growth and activities of sulphate-reducing bacteria in gut contents of health subjects and patients with ulcerative colitis","volume":"86","author":"Gibson","year":"1991","journal-title":"FEMS Microbiol Ecol"},{"key":"10.1016\/j.jare.2020.03.007_b0025","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1128\/jcm.35.7.1805-1808.1997","article-title":"Bacteremia caused by a recently described novel Desulfovibrio species","volume":"35","author":"McDougall","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jare.2020.03.007_b0030","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1128\/JCM.38.2.931-934.2000","article-title":"Bacteremia caused by a strain of Desulfovibrio related to the provisionally named Desulfovibrio fairfieldensis","volume":"38","author":"Loubinoux","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jare.2020.03.007_b0035","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/bjs.6454","article-title":"Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis","volume":"96","author":"Rowan","year":"2009","journal-title":"Br J Surg"},{"key":"10.1016\/j.jare.2020.03.007_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/gut.39.1.1","article-title":"Hydrogen sulphide: A bacterial toxin in ulcerative colitis?","volume":"39","author":"Pitcher","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.jare.2020.03.007_b0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2754\/avb201585010003","article-title":"Activity of Na+\/K+-activated Mg2+-dependent ATP hydrolase in the cell-free extracts of the sulfate-reducing bacteria Desulfovibrio piger Vib-7 and Desulfomicrobium sp","volume":"84","author":"Kushkevych","year":"2015","journal-title":"Rod-9 Acta Vet Brno"},{"key":"10.1016\/j.jare.2020.03.007_b0050","first-page":"1037","article-title":"Activity and kinetic properties of phosphotransacetylase from intestinal sulfate-reducing bacteria","volume":"62","author":"Kushkevych","year":"2015","journal-title":"Acta Biochem Pol"},{"key":"10.1016\/j.jare.2020.03.007_b0055","doi-asserted-by":"crossref","first-page":"107","DOI":"10.33073\/pjm-2015-016","article-title":"Kinetic Properties of Pyruvate Ferredoxin Oxidoreductase of Intestinal Sulfate-Reducing Bacteria Desulfovibrio piger Vib-7 and Desulfomicrobium sp. Rod-9","volume":"64","author":"Kushkevych","year":"2015","journal-title":"Pol J Microbiol"},{"key":"10.1016\/j.jare.2020.03.007_b0060","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1574-6941.1993.tb00023.x","article-title":"Metabolic interactions involving sulphate-reducing and methanogenic bacteria in the human large intestine","volume":"12","author":"Gibson","year":"1993","journal-title":"FEMS Microbiol Ecol"},{"key":"10.1016\/j.jare.2020.03.007_b0065","first-page":"9","article-title":"Intestinal bacteria and ulcerative colitis","volume":"4","author":"Cummings","year":"2003","journal-title":"Curr Issues Intest Microbiol"},{"key":"10.1016\/j.jare.2020.03.007_b0070","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.2478\/s11756-018-0118-2","article-title":"Cross-correlation analysis of the Desulfovibrio growth parameters of intestinal species isolated from people with colitis","volume":"73","author":"Kushkevych","year":"2018","journal-title":"Biologia"},{"key":"10.1016\/j.jare.2020.03.007_b0075","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1515\/med-2019-0010","article-title":"Analysis of pH dose-dependent growth of sulfate-reducing bacteria","volume":"14","author":"Kushkevych","year":"2019","journal-title":"Open Med"},{"key":"10.1016\/j.jare.2020.03.007_b0080","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1515\/biol-2018-0057","article-title":"Analysis of physiological parameters of Desulfovibrio strains from individuals with colitis","volume":"13","author":"Kushkevych","year":"2018","journal-title":"Open Life Sci"},{"key":"10.1016\/j.jare.2020.03.007_b0085","doi-asserted-by":"crossref","unstructured":"Brenner DJ., Krieg NR, Staley JT, Garrity GM. Bergey\u2019s manual of Systematic Bacteriology. The Proteobacteria, Part C: The Alpha-, Beta-, Delta-, and Epsilonproteobacteria. Second Edition. Printed in the United States of America, 2005; 2: 1388 p.","DOI":"10.1007\/0-387-29298-5"},{"key":"10.1016\/j.jare.2020.03.007_b0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/1541-7786.MCR-05-0126","article-title":"Evidence that hydrogen sulfide is a genotoxic agent","volume":"4","author":"Attene-Ramos","year":"2006","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.jare.2020.03.007_b0095","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/10408448409029321","article-title":"A critical review of the literature on hydrogen sulfide toxicity","volume":"13","author":"Beauchamp","year":"1984","journal-title":"CRC Crit Rev Toxicol"},{"key":"10.1016\/j.jare.2020.03.007_b0100","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00726-009-0445-2","article-title":"Luminal sulfide and large intestine mucosa: Friend or foe?","volume":"39","author":"Blachier","year":"2010","journal-title":"Amino Acids"},{"key":"10.1016\/j.jare.2020.03.007_b0105","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00203-019-01625-z","article-title":"Toxicity of hydrogen sulfide toward sulfate-reducing bacteria Desulfovibrio piger Vib-7","volume":"201","author":"Kushkevych","year":"2019","journal-title":"Arch Microbiol"},{"key":"10.1016\/j.jare.2020.03.007_b0110","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.3390\/jcm8071054","article-title":"Hydrogen sulfide as a toxic product in the small-large intestine axis and its role in IBD development","volume":"8","author":"Kushkevych","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.jare.2020.03.007_b0115","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jab.2018.01.004","article-title":"Effect of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger","volume":"16","author":"Kushkevych","year":"2018","journal-title":"J Appl Biomed"},{"key":"10.1016\/j.jare.2020.03.007_b0120","first-page":"106","article-title":"Activity of selected salicylamides against intestinal sulfate-reducing bacteria","volume":"36","author":"Kushkevych","year":"2015","journal-title":"Neuroendocrinol Lett"},{"key":"10.1016\/j.jare.2020.03.007_b0125","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jab.2016.01.005","article-title":"Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria","volume":"14","author":"Kushkevych","year":"2016","journal-title":"J Appl Biomed"},{"key":"10.1016\/j.jare.2020.03.007_b0130","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s00044-017-2067-7","article-title":"Activity of ring-substituted 8-hydroxyquinoline-2-carboxanilides against intestinal sulfate-reducing bacteria Desulfovibrio piger","volume":"27","author":"Kushkevych","year":"2018","journal-title":"Med Chem Res"},{"key":"10.1016\/j.jare.2020.03.007_b0135","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1365-2672.2007.03287.x","article-title":"Microbial biofilms in the human gastrointestinal tract","volume":"102","author":"Macfarlane","year":"2007","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.jare.2020.03.007_b0140","first-page":"64","article-title":"Bacterial growth and metabolism on surfaces in the large intestine","volume":"2","author":"Macfarlane","year":"2000","journal-title":"Microb Ecol Health Dis"},{"key":"10.1016\/j.jare.2020.03.007_b0145","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/10408448409029321","article-title":"A critical review of the literature on hydrogen sulfide toxicity","volume":"13","author":"Beauchamp","year":"1984","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.jare.2020.03.007_b0150","series-title":"Proceedings of the International PhD Students Conference MendelNet, Brno, Czech Republic, 6\u20137 November 2017","first-page":"702","article-title":"New modification of cultivation medium for isolation and growth of intestinal sulfate-reducing bacteria","author":"Kov\u00e1\u010d","year":"2017"},{"key":"10.1016\/j.jare.2020.03.007_b0155","series-title":"The Sulfate Reducing Bacteria","author":"Postgate","year":"1984"},{"key":"10.1016\/j.jare.2020.03.007_b0160","unstructured":"Kushkevych I. Isolation and Purification of Sulfate-Reducing Bacteria. In: Microorganisms edited by: Dr. Miroslav Blumenberg. IntechOpen, London, UK."},{"issue":"2","key":"10.1016\/j.jare.2020.03.007_b0165","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1128\/jb.173.2.697-703.1991","article-title":"16S ribosomal DNA amplification for phylogenetic study","volume":"173","author":"Weisburg","year":"1991","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jare.2020.03.007_b0170","series-title":"Molecular Microbiology: Diagnostic Principles and Practice","first-page":"960","author":"Persing","year":"2011"},{"key":"10.1016\/j.jare.2020.03.007_b0175","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4319\/lo.1969.14.3.0454","article-title":"Spectrophotometric determination of hydrogen sulfide in natural water","volume":"14","author":"Cline","year":"1969","journal-title":"Limnol Oceanogr"},{"key":"10.1016\/j.jare.2020.03.007_b0180","series-title":"Statistical Methods in Biology","author":"Bailey","year":"1995"},{"key":"10.1016\/j.jare.2020.03.007_b0185","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.3390\/en11123270","article-title":"Variation in the distribution of hydrogen producers from the clostridiales order in biogas reactors depending on different input substrates","volume":"11","author":"\u010cern\u00fd","year":"2018","journal-title":"Energies"},{"key":"10.1016\/j.jare.2020.03.007_b0190","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1515\/biol-2017-0009","article-title":"Production of biogas: Relationship between methanogenic and sulfate-reducing microorganisms","volume":"12","author":"Kushkevych","year":"2017","journal-title":"Open Life Sci"},{"key":"10.1016\/j.jare.2020.03.007_b0195","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/0016-5085(93)91016-B","article-title":"Reducing sulfur compounds of colon impair colonocyte nutrition: implications for ulcerative colitis","volume":"104","author":"Roediger","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jare.2020.03.007_b0200","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1172\/JCI7712","article-title":"Detoxification of hydrogen sulfide and methanethiol in the cecal mucosa","volume":"104","author":"Levitt","year":"1999","journal-title":"J Clin Investing"},{"key":"10.1016\/j.jare.2020.03.007_b0205","first-page":"137","article-title":"The effect of antibiotics and bismuth on fecal hydrogen sulfide and sulfate-reducing bacteria in the rat","volume":"Vol. 228","author":"Ohge","year":"2003"},{"issue":"5","key":"10.1016\/j.jare.2020.03.007_b0210","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s002849900257","article-title":"Nutritional aspects of dissimilatory sulfate reduction in the human large intestine","volume":"35","author":"Willis","year":"1997","journal-title":"Curr Microbiol"},{"issue":"1","key":"10.1016\/j.jare.2020.03.007_b0215","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1572-0241.1998.083_c.x","article-title":"Fecal hydrogen sulfide production in ulcerative colitis","volume":"93","author":"Levine","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jare.2020.03.007_b0220","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1099\/00207713-52-4-1305","article-title":"Reclassification of the only species of the genus Desulfomonas, Desulfomonas pigra, as Desulfovibrio piger comb. nov","volume":"52","author":"Loubinoux","year":"2002","journal-title":"Int J Syst Evol Microbiol"},{"key":"10.1016\/j.jare.2020.03.007_b0225","first-page":"238","article-title":"Emendation of Bacteroidaceae and Butyrivibrio and descriptions of Desulfomonas gen. nov. and ten new species of the genera Desulfomonas, Butyrivibrio, Eubacterium, Clostridium and Ruminococcus","volume":"Vol. 26","author":"Moore","year":"1976"},{"key":"10.1016\/j.jare.2020.03.007_b0230","first-page":"1035","article-title":"Isolation of Desulfomicrobium orale sp. nov. and Desulfovibrio strain NY682, oral sulfate-reducing bacteria involved in human periodontal disease","volume":"Vol. 51","author":"Langendijk","year":"2001"},{"key":"10.1016\/j.jare.2020.03.007_b0235","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1006\/jfca.1993.1016","article-title":"Sulfate in food and beverages","volume":"6","author":"Florin","year":"1993","journal-title":"J Food Compos Anal"},{"key":"10.1016\/j.jare.2020.03.007_b0240","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1515\/biol-2018-0017","article-title":"A new combination of substrates: Biogas production and diversity of the methanogenic microorganisms","volume":"13","author":"Kushkevych","year":"2018","journal-title":"Open Life Sci"},{"key":"10.1016\/j.jare.2020.03.007_b0245","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s00203-018-1510-6","article-title":"The diversity of sulfate-reducing bacteria in the seven bioreactors","volume":"200","author":"Kushkevych","year":"2018","journal-title":"Arch Microbiol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123220300564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123220300564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T20:49:30Z","timestamp":1761857370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123220300564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":49,"alternative-id":["S2090123220300564"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2020.03.007","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible synergy effect of hydrogen sulfide and acetate produced by sulfate-reducing bacteria on inflammatory bowel disease development","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2020.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}