{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:31:14Z","timestamp":1786991474170,"version":"build-2736575974"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673554"],"award-info":[{"award-number":["81673554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jare.2020.06.020","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T21:16:06Z","timestamp":1592946966000},"page":"255-267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Quercitrin alleviates cartilage extracellular matrix degradation and delays ACLT rat osteoarthritis development: An in vivo and in vitro study"],"prefix":"10.1016","volume":"28","author":[{"given":"Hanli","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziling","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingtian","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4791-8615","authenticated-orcid":false,"given":"Lingyi","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jare.2020.06.020_b0005","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.joca.2016.07.017","article-title":"Disease-modifying treatments for osteoarthritis (Dmoads) of the knee and hip: lessons learned from failures and opportunities for the future","volume":"24","author":"Karsdal","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"10.1016\/j.jare.2020.06.020_b0010","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrrheum.2011.109","article-title":"Autophagy and cartilage homeostasis mechanisms in joint health, aging and Oa","volume":"7","author":"Lotz","year":"2011","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"10.1016\/j.jare.2020.06.020_b0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrrheum.2010.178","article-title":"Pharmacologic therapy for osteoarthritis\u2013the era of disease modification","volume":"7","author":"Hunter","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jare.2020.06.020_b0020","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (Ylds) for 1160 Sequelae of 289 diseases and injuries 1990\u20132010: a systematic analysis for the global burden of disease study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"The Lancet"},{"issue":"9991","key":"10.1016\/j.jare.2020.06.020_b0025","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"The Lancet"},{"key":"10.1016\/j.jare.2020.06.020_b0030","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.phrs.2018.09.026","article-title":"Fibroblast growth factor 18 exerts anti-osteoarthritic effects through Pi3k-Akt signaling and mitochondrial fusion and fission","volume":"139","author":"Yao","year":"2019","journal-title":"Pharmacol Res"},{"issue":"9","key":"10.1016\/j.jare.2020.06.020_b0035","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2106\/JBJS.15.00623","article-title":"Clinical outcomes and development of symptomatic osteoarthritis 2 to 24 years after surgical treatment of tarsometatarsal joint complex injuries","volume":"98","author":"Dubois-Ferriere","year":"2016","journal-title":"J Bone Joint Surg"},{"issue":"4","key":"10.1016\/j.jare.2020.06.020_b0040","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/annrheumdis-2015-209029","article-title":"Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women","volume":"75","author":"Kluzek","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"10.1016\/j.jare.2020.06.020_b0045","doi-asserted-by":"crossref","first-page":"688","DOI":"10.2106\/JBJS.15.01311","article-title":"The American academy of orthopaedic surgeons evidence-based clinical practice guideline on surgical management of osteoarthritis of the knee","volume":"98","author":"McGrory","year":"2016","journal-title":"J Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.jare.2020.06.020_b0050","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1038\/s41467-019-09839-x","article-title":"A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development","volume":"10","author":"Shi","year":"2019","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.jare.2020.06.020_b0055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.joca.2011.12.003","article-title":"Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?","volume":"20","author":"van der Kraan","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.jare.2020.06.020_b0060","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.berh.2006.06.003","article-title":"Update on the biology of the chondrocyte and new approaches to treating cartilage diseases","volume":"20","author":"Goldring","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.jare.2020.06.020_b0065","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1177\/147323000803600601","article-title":"Aggrecanase and aggrecan degradation in osteoarthritis: a review","volume":"36","author":"Huang","year":"2008","journal-title":"J Int Med Res"},{"key":"10.1016\/j.jare.2020.06.020_b0070","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/ard.61.suppl_2.ii78","article-title":"Type II collagen degradation and its regulation in articular cartilage in osteoarthritis","volume":"61","author":"Poole","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2020.06.020_b0075","first-page":"107","article-title":"Articular cartilage and changes in arthritis an introduction: cell biology of osteoarthritis","volume":"3","author":"Sandell","year":"2001","journal-title":"J Arthritis"},{"issue":"3","key":"10.1016\/j.jare.2020.06.020_b0080","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/ar2592","article-title":"Cartilage homeostasis in health and rheumatic diseases","volume":"11","author":"Goldring","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jare.2020.06.020_b0085","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0014-5793(95)01539-6","article-title":"Degradation of cartilage aggrecan by collagenase-3 (Mmp-13)","volume":"380","author":"Fosang","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jare.2020.06.020_b0090","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/ar4133","article-title":"Mmp13 is a critical target gene during the progression of osteoarthritis","volume":"15","author":"Wang","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jare.2020.06.020_b0095","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1172\/JCI118475","article-title":"Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage","volume":"97","author":"Mitchell","year":"1996","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.jare.2020.06.020_b0100","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.cell.2014.01.007","article-title":"Regulation of the catabolic cascade in osteoarthritis by the Zinc-Zip8-Mtf1 axis","volume":"156","author":"Kim","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jare.2020.06.020_b0105","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1038\/ncomms15019","article-title":"Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression","volume":"8","author":"Corciulo","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2020.06.020_b0110","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2016","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.jare.2020.06.020_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2167-7921.1000239","article-title":"Role of microrna in osteoarthritis","volume":"6","author":"Zhang","year":"2017","journal-title":"J Arthritis"},{"issue":"10","key":"10.1016\/j.jare.2020.06.020_b0120","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.joca.2017.06.002","article-title":"Intra-articular injection of Microrna-140 (Mirna-140) alleviates osteoarthritis (Oa) progression by modulating extracellular matrix (Ecm) homeostasis in rats","volume":"25","author":"Si","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jare.2020.06.020_b0125","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.18632\/aging.102194","article-title":"Mir-27a promotes the autophagy and apoptosis of Il-1\u03b2 treatedarticular chondrocytes in osteoarthritis through Pi3k_Akt_Mtor signaling","volume":"11","author":"Cai","year":"2019","journal-title":"Aging"},{"issue":"8","key":"10.1016\/j.jare.2020.06.020_b0130","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrc2664","article-title":"Targeting Pi3k signalling in cancer: opportunities challenges and limitations","volume":"9","author":"Engelman","year":"2009","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"10.1016\/j.jare.2020.06.020_b0135","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10822-017-0092-8","article-title":"Discovering new Pi3kalpha inhibitors with a strategy of combining ligand-based and structure-based virtual screening","volume":"32","author":"Yu","year":"2018","journal-title":"J Comput Aided Mol Des"},{"key":"10.1016\/j.jare.2020.06.020_b0140","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ceb.2017.02.007","article-title":"Pi3k signaling in cancer: beyond Akt","volume":"45","author":"Lien","year":"2017","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.jare.2020.06.020_b0145","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1038\/sj.onc.1210918","article-title":"Oncogenic signaling of class I Pi3k isoforms","volume":"27","author":"Denley","year":"2008","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.jare.2020.06.020_b0150","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.coph.2008.08.004","article-title":"Targeting the Pi3k-Akt-Mtor pathway_ progress, pitfalls, and promises","volume":"8","author":"Yap","year":"2008","journal-title":"Curr Opin Pharmacol"},{"issue":"3","key":"10.1016\/j.jare.2020.06.020_b0155","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1158\/1535-7163.MCT-10-0994","article-title":"Pik3ca mutations in patients with advanced cancers treated with Pi3k\/Akt\/Mtor axis inhibitors","volume":"10","author":"Janku","year":"2011","journal-title":"Mol Cancer Ther"},{"issue":"9","key":"10.1016\/j.jare.2020.06.020_b0160","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.4161\/cc.8.9.8255","article-title":"Pik3ca mutations in human solid tumors: role in sensitivity to various therapeutic approaches","volume":"8","author":"Ligresti","year":"2009","journal-title":"Cell Cycle"},{"issue":"12","key":"10.1016\/j.jare.2020.06.020_b0165","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1016\/j.ymthe.2017.08.009","article-title":"Microrna-218-5p as a potential target for the treatment of human osteoarthritis","volume":"25","author":"Lu","year":"2017","journal-title":"Mol Ther"},{"key":"10.1016\/j.jare.2020.06.020_b0170","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/art.24225","article-title":"Increased expression of the Akt_Pkb inhibitor Trb3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1\u2013mediated cell survival and proteoglycan synthesis","volume":"60","author":"Cravero","year":"2009","journal-title":"Arthrit Rheum-Arthr"},{"key":"10.1016\/j.jare.2020.06.020_b0175","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.joca.2014.02.631","article-title":"Cartilage-specific deletion of Mtor upregulates autophagy and protects mice from osteoarthritis","volume":"22","author":"Zhang","year":"2014","journal-title":"Osteoarthr Cartilage"},{"key":"10.1016\/j.jare.2020.06.020_b0180","doi-asserted-by":"crossref","first-page":"23117","DOI":"10.1038\/srep23117","article-title":"Overexpression of Microrna-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting Pik3r1","volume":"6","author":"Cui","year":"2016","journal-title":"Sci Rep"},{"issue":"30","key":"10.1016\/j.jare.2020.06.020_b0185","first-page":"918","article-title":"Treatment of Chinese medicine in early, mid-term period of knee osteoarthritis","volume":"5","author":"Liu","year":"2014","journal-title":"J Changchun Univ Traditional Chin Med"},{"key":"10.1016\/j.jare.2020.06.020_b0190","series-title":"Data mining and clinical drug efficacy analysis on Chinese medicine treatment of knee osteoarthritis [dissertation]","author":"Huang","year":"2015"},{"issue":"23","key":"10.1016\/j.jare.2020.06.020_b0195","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.5897\/AJPP12.1327","article-title":"Analgesic and anti-inflammatory activities of the ethanol extract of Taxillus sutchuenensis in mice","volume":"7","author":"Liu","year":"2013","journal-title":"Afr J Pharm Pharmacol"},{"issue":"22","key":"10.1016\/j.jare.2020.06.020_b0200","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1021\/jf034543e","article-title":"Tartary Buckwheat (Fagopyrum Tataricum Gaertn.) as a Source of Dietary Rutin and Quercitrin","volume":"51","author":"Fabjan","year":"2003","journal-title":"J Agr Food Chem"},{"key":"10.1016\/j.jare.2020.06.020_b0205","doi-asserted-by":"crossref","unstructured":"B. AW, H. GR, B. A. Health effects of quercitrin: from antioxidant to nutraceutical. Eur J Pharmacol 2008;585(2\u20133):325\u201337.","DOI":"10.1016\/j.ejphar.2008.03.008"},{"key":"10.1016\/j.jare.2020.06.020_b0210","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/978-1-4419-7756-4_38","article-title":"Antioxidant properties of quercitrin","volume":"701","author":"Zhang","year":"2011","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jare.2020.06.020_b0215","doi-asserted-by":"crossref","unstructured":"A.P. Rogerio, A. Kanashiro, C. Fontanari, E.V.G.D. Silva, Y.M. Lucisano-Valim, E.G. Soares, L.H. Faccioli. Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma. INFLAMM RES 2007;56:402\u20138.","DOI":"10.1007\/s00011-007-7005-6"},{"key":"10.1016\/j.jare.2020.06.020_b0220","doi-asserted-by":"crossref","unstructured":"B. AW, W. LC, S. EL, K. JC, B. A, H. GR. In vitro and ex vivo anti-inflammatory activity of quercitrin in healthy volunteers. Nutrition 2008;24(7\u20138):703\u201310.","DOI":"10.1016\/j.nut.2008.03.023"},{"key":"10.1016\/j.jare.2020.06.020_b0225","doi-asserted-by":"crossref","unstructured":"L. BH, J. SM, L. JH, K. JH, Y. IS, L. JH, C. SH, L. SM, C. CG, K. HC, H. Y, P. HD, K. Y, N. SY. Quercitrin inhibits the 5-hydroxytryptamine type 3 receptor-mediated ion current by interacting with pre-transmembr quercitrin domain I. Mol Cells 2005;20(1):69\u201373.","DOI":"10.1016\/S1016-8478(23)13200-6"},{"issue":"10","key":"10.1016\/j.jare.2020.06.020_b0230","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.bcp.2013.09.009","article-title":"Quercitrin and taxifolin stimulate osteoblast differentiation in Mc3t3-E1 cells and inhibit osteoclastogenesis in raw 264.7 cells","volume":"86","author":"Satue","year":"2013","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"10.1016\/j.jare.2020.06.020_b0235","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.etp.2010.08.008","article-title":"Protective effect of quercitrin against hydrogen peroxide-induced dysfunction in osteoblastic Mc3t3-E1 cells","volume":"64","author":"Choi","year":"2012","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.jare.2020.06.020_b0240","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.biopha.2017.02.073","article-title":"Quercitrin attenuates osteoporosis in ovariectomized rats by regulating mitogen-activated protein kinase (Mapk) signaling pathways","volume":"89","author":"Xing","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jare.2020.06.020_b0245","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/jor.22250","article-title":"Monosodium iodoacetate induces apoptosis via the mitochondrial pathway involving ros production and caspase activation in rat chondrocytes in vitro","volume":"31","author":"Jiang","year":"2013","journal-title":"Inc J Orthop Res"},{"key":"10.1016\/j.jare.2020.06.020_b0250","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.3390\/ijms17101522","article-title":"Cxcl12_Cxcr4 axis regulates aggrecanase activation and cartilage degradation in a post-traumatic osteoarthritis rat model","volume":"17","author":"Lu","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2020.06.020_b0255","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bbrc.2016.06.071","article-title":"Microrna-23a-3p promotes the development of osteoarthritis by directly targeting Smad3 in chondrocytes","volume":"478","author":"Kang","year":"2016","journal-title":"Biochem Bioph Res Co"},{"key":"10.1016\/j.jare.2020.06.020_b0260","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3389\/fphar.2017.00693","article-title":"Meclizine prevents ovariectomy-induced bone loss and inhibits osteoclastogenesis partially by upregulating Pxr","volume":"8","author":"Guo","year":"2017","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2020.06.020_b0265","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2019.09.024","article-title":"Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages","volume":"145","author":"Hu","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.jare.2020.06.020_b0270","doi-asserted-by":"crossref","first-page":"101965","DOI":"10.18632\/oncotarget.21949","article-title":"Tomentodione M Sensitizes multidrug resistant cancer cells by decreasing P-glycoprotein via inhibition of P38 Mapk signalling (article)","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jare.2020.06.020_b0275","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.phymed.2016.12.014","article-title":"Eucalrobusone C Suppresses cell proliferation and induces Ros-dependent mitochondrial apoptosis via the P38 Mapk pathway in hepatocellular carcinoma cells","volume":"25","author":"Jian","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jare.2020.06.020_b0280","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.canlet.2017.09.021","article-title":"Grp78 inhibition enhances Atf4-induced cell death by the deubiquitination and stabilization of chop in human osteosarcoma","volume":"410","author":"Luo","year":"2017","journal-title":"Cancer Lett"},{"issue":"8","key":"10.1016\/j.jare.2020.06.020_b0285","first-page":"1197","article-title":"Loss of Vhl in cartilage accelerated the progression of ageassociated and surgically induced murine osteoarthritis","volume":"22","author":"Weng","year":"2014","journal-title":"NIH Public Access"},{"issue":"6","key":"10.1016\/j.jare.2020.06.020_b0290","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17060943","article-title":"Inhibition of Sdf-1alpha\/Cxcr4 signalling in subchondral bone attenuates post-traumatic osteoarthritis","volume":"17","author":"Dong","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"Suppl 3","key":"10.1016\/j.jare.2020.06.020_b0295","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The Oarsi histopathology initiative \u2013 recommendations for histological assessments of osteoarthritis in the rat","volume":"18","author":"Gerwin","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"10.1016\/j.jare.2020.06.020_b0300","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1111\/jcmm.13227","article-title":"Anemonin attenuates osteoarthritis progression through inhibiting the activation of Il-1beta\/Nf-Kappab pathway","volume":"21","author":"Wang","year":"2017","journal-title":"J Cell Mol Med"},{"issue":"1","key":"10.1016\/j.jare.2020.06.020_b0305","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3892\/ijmm.2016.2618","article-title":"Microrna-34a affects chondrocyte apoptosis and proliferation by targeting the Sirt1\/P53 Signaling pathway during the pathogenesis of osteoarthritis","volume":"38","author":"Yan","year":"2016","journal-title":"Int J Mol Med"},{"issue":"6","key":"10.1016\/j.jare.2020.06.020_b0310","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00223-014-9917-9","article-title":"Osteoarthritis pathogenesis: a review of molecular mechanisms","volume":"95","author":"Xia","year":"2014","journal-title":"Calcif Tissue Int"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123220301296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123220301296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T20:50:43Z","timestamp":1761857443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123220301296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":62,"alternative-id":["S2090123220301296"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2020.06.020","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercitrin alleviates cartilage extracellular matrix degradation and delays ACLT rat osteoarthritis development: An in vivo and in vitro study","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2020.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}