{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:12:28Z","timestamp":1791000748371,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jare.2020.09.007","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T12:19:16Z","timestamp":1601295556000},"page":"33-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Melatonin as a therapy in cardiac ischemia-reperfusion injury: Potential mechanisms by which MT2 activation mediates cardioprotection"],"prefix":"10.1016","volume":"29","author":[{"given":"Kodchanan","family":"Singhanat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattayaporn","family":"Apaijai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thidarat","family":"Jaiwongkam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasiwan","family":"Kerdphoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn C.","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-718X","authenticated-orcid":false,"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jare.2020.09.007_b0005","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ejheart.2004.10.020","article-title":"Economic burden of post-acute myocardial infarction heart failure in the United Kingdom","volume":"7","author":"Lacey","year":"2005","journal-title":"Eur J Heart Fail."},{"issue":"7","key":"10.1016\/j.jare.2020.09.007_b0010","doi-asserted-by":"crossref","first-page":"A389","DOI":"10.1016\/j.jval.2015.09.857","article-title":"Economic Burden Of Acute Myocardial Infarction In Vietnam","volume":"18","author":"Nguyen","year":"2015","journal-title":"Value Health."},{"issue":"3","key":"10.1016\/j.jare.2020.09.007_b0015","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6","article-title":"Pathophysiology of ischaemia-reperfusion injury","volume":"190","author":"Carden","year":"2000","journal-title":"J Pathol."},{"issue":"5","key":"10.1016\/j.jare.2020.09.007_b0020","doi-asserted-by":"crossref","first-page":"H1723","DOI":"10.1152\/ajpheart.00553.2011","article-title":"Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures","volume":"301","author":"Sanada","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol."},{"issue":"3","key":"10.1016\/j.jare.2020.09.007_b0025","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.pneurobio.2008.04.001","article-title":"Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways","volume":"85","author":"Pandi-Perumal","year":"2008","journal-title":"Prog Neurobiol."},{"issue":"16","key":"10.1016\/j.jare.2020.09.007_b0030","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1007\/s00018-014-1579-2","article-title":"Extrapineal melatonin: sources, regulation, and potential functions","volume":"71","author":"Acuna-Castroviejo","year":"2014","journal-title":"Cell Mol Life Sci."},{"issue":"3","key":"10.1016\/j.jare.2020.09.007_b0035","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.recesp.2011.10.009","article-title":"Melatonin and cardiovascular disease: myth or reality?","volume":"65","author":"Dominguez-Rodriguez","year":"2012","journal-title":"Rev Esp Cardiol (Engl Ed)."},{"key":"10.1016\/j.jare.2020.09.007_b0040","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3389\/fphys.2018.00528","article-title":"Cardiovascular Benefits of Dietary Melatonin: A Myth or a Reality?","volume":"9","author":"Jiki","year":"2018","journal-title":"Front Physiol."},{"key":"10.1016\/j.jare.2020.09.007_b0045","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.ijcard.2016.07.108","article-title":"Melatonin effects on myocardial ischemia-reperfusion injury: Impact on the outcome in patients undergoing coronary artery bypass grafting surgery","volume":"221","author":"Dwaich","year":"2016","journal-title":"Int J Cardiol."},{"issue":"5\u20136","key":"10.1016\/j.jare.2020.09.007_b0050","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s12265-017-9768-7","article-title":"Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial","volume":"10","author":"Ekeloef","year":"2017","journal-title":"J Cardiovasc Transl Res."},{"issue":"1","key":"10.1016\/j.jare.2020.09.007_b0055","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12571","article-title":"Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia\/reperfusion injury","volume":"67","author":"Han","year":"2019","journal-title":"J Pineal Res."},{"issue":"5","key":"10.1016\/j.jare.2020.09.007_b0060","doi-asserted-by":"crossref","first-page":"491","DOI":"10.33549\/physiolres.930664","article-title":"Protective effects of melatonin on myocardial ischemia\/reperfusion induced infarct size and oxidative changes","volume":"54","author":"Sahna","year":"2005","journal-title":"Physiol Res."},{"issue":"3","key":"10.1016\/j.jare.2020.09.007_b0065","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.4238\/2015.July.3.24","article-title":"Effect of melatonin on oncosis of myocardial cells in the myocardial ischemia\/reperfusion injury rat and the role of the mitochondrial permeability transition pore","volume":"14","author":"Liu","year":"2015","journal-title":"Genet Mol Res."},{"issue":"2","key":"10.1016\/j.jare.2020.09.007_b0070","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1600-079X.2008.00654.x","article-title":"Prevention of ischemia\/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1","volume":"46","author":"Chen","year":"2009","journal-title":"J Pineal Res."},{"issue":"1","key":"10.1016\/j.jare.2020.09.007_b0075","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12413","article-title":"Melatonin protects cardiac microvasculature against ischemia\/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis","volume":"63","author":"Zhou","year":"2017","journal-title":"J Pineal Res."},{"issue":"7","key":"10.1016\/j.jare.2020.09.007_b0080","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s10495-016-1246-1","article-title":"Melatonin reduces PERK-eIF2alpha-ATF4-mediated endoplasmic reticulum stress during myocardial ischemia-reperfusion injury: role of RISK and SAFE pathways interaction","volume":"21","author":"Yu","year":"2016","journal-title":"Apoptosis"},{"issue":"2","key":"10.1016\/j.jare.2020.09.007_b0085","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.bbadis.2017.11.023","article-title":"Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation","volume":"1864","author":"Yu","year":"2017","journal-title":"Biochim Biophys Acta."},{"issue":"4","key":"10.1016\/j.jare.2020.09.007_b0090","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/MOL.0000000000000314","article-title":"Effects of melatonin on cardiovascular diseases: progress in the past year","volume":"27","author":"Sun","year":"2016","journal-title":"Curr Opin Lipidol."},{"issue":"4","key":"10.1016\/j.jare.2020.09.007_b0095","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1600-079X.2008.00615.x","article-title":"Melatonin receptor-mediated protection against myocardial ischaemia\/reperfusion injury: role of its anti-adrenergic actions","volume":"45","author":"Genade","year":"2008","journal-title":"J Pineal Res."},{"issue":"2","key":"10.1016\/j.jare.2020.09.007_b0100","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/jpi.12161","article-title":"Melatonin receptor-mediated protection against myocardial ischemia\/reperfusion injury: role of SIRT1","volume":"57","author":"Yu","year":"2014","journal-title":"J Pineal Res."},{"issue":"4","key":"10.1016\/j.jare.2020.09.007_b0105","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/jpi.12272","article-title":"Membrane receptor-dependent Notch1\/Hes1 activation by melatonin protects against myocardial ischemia-reperfusion injury: in vivo and in vitro studies","volume":"59","author":"Yu","year":"2015","journal-title":"J Pineal Res."},{"issue":"12","key":"10.1016\/j.jare.2020.09.007_b0110","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/j.hrthm.2011.06.036","article-title":"Ischemic ventricular arrhythmias: experimental models and their clinical relevance","volume":"8","author":"Di Diego","year":"2011","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.jare.2020.09.007_b0115","first-page":"68","article-title":"Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog","volume":"70","author":"Jennings","year":"1960","journal-title":"Arch Pathol."},{"issue":"4","key":"10.1016\/j.jare.2020.09.007_b0120","first-page":"209","article-title":"Clinical manifestations and basic mechanisms of myocardial ischemia\/reperfusion injury","volume":"30","author":"Yang","year":"2018","journal-title":"Ci Ji Yi Xue Za Zhi."},{"issue":"3","key":"10.1016\/j.jare.2020.09.007_b0125","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.amjcard.2010.03.032","article-title":"Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy","volume":"106","author":"Turer","year":"2010","journal-title":"Am J Cardiol."},{"issue":"11","key":"10.1016\/j.jare.2020.09.007_b0130","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N Engl J Med."},{"issue":"1","key":"10.1016\/j.jare.2020.09.007_b0135","first-page":"44","article-title":"Melatonin-Induced Protective Effects on Cardiomyocytes Against Reperfusion Injury Partly Through Modulation of IP3R and SERCA2a Via Activation of ERK1","volume":"110","author":"Hu","year":"2018","journal-title":"Arq Bras Cardiol."},{"issue":"2","key":"10.1016\/j.jare.2020.09.007_b0140","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12542","article-title":"Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion\/mitophagy and activating the AMPK-OPA1 signaling pathways","volume":"66","author":"Zhang","year":"2019","journal-title":"J Pineal Res."},{"issue":"1","key":"10.1016\/j.jare.2020.09.007_b0145","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12192-017-0827-4","article-title":"Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via suppression of IP3R-[Ca(2+)]c\/VDAC-[Ca(2+)]m axis by activation of MAPK\/ERK signaling pathway","volume":"23","author":"Zhu","year":"2018","journal-title":"Cell Stress Chaperones."},{"issue":"3","key":"10.1016\/j.jare.2020.09.007_b0150","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/jpi.12070","article-title":"JAK2\/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia\/reperfusion injury","volume":"55","author":"Yang","year":"2013","journal-title":"J Pineal Res."},{"issue":"2","key":"10.1016\/j.jare.2020.09.007_b0155","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12419","article-title":"Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis","volume":"63","author":"Zhai","year":"2017","journal-title":"J Pineal Res."},{"issue":"6","key":"10.1016\/j.jare.2020.09.007_b0160","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/1755-5922.12210","article-title":"Humanin exerts cardioprotection against cardiac ischemia\/reperfusion injury through attenuation of mitochondrial dysfunction","volume":"34","author":"Thummasorn","year":"2016","journal-title":"Cardiovasc Ther."},{"issue":"7","key":"10.1016\/j.jare.2020.09.007_b0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102374","article-title":"Combined vildagliptin and metformin exert better cardioprotection than monotherapy against ischemia-reperfusion injury in obese-insulin resistant rats","volume":"9","author":"Apaijai","year":"2014","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.jare.2020.09.007_b0170","doi-asserted-by":"crossref","DOI":"10.1111\/1755-5922.12289","article-title":"High-dose Humanin analogue applied during ischemia exerts cardioprotection against ischemia\/reperfusion injury by reducing mitochondrial dysfunction","volume":"35","author":"Thummasorn","year":"2017","journal-title":"Cardiovasc Ther."},{"issue":"15","key":"10.1016\/j.jare.2020.09.007_b0175","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1042\/CS20180510","article-title":"Differential temporal inhibition of mitochondrial fission by Mdivi-1 exerts effective cardioprotection in cardiac ischemia\/reperfusion injury","volume":"132","author":"Maneechote","year":"2018","journal-title":"Clin Sci (Lond)."},{"issue":"3","key":"10.1016\/j.jare.2020.09.007_b0180","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1042\/CS20190014","article-title":"Balancing mitochondrial dynamics via increasing mitochondrial fusion attenuates infarct size and left ventricular dysfunction in rats with cardiac ischemia\/reperfusion injury","volume":"133","author":"Maneechote","year":"2019","journal-title":"Clin Sci (Lond)."},{"issue":"1","key":"10.1016\/j.jare.2020.09.007_b0185","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1600-079X.2005.00280.x","article-title":"Short- and long-term effects of melatonin on myocardial post-ischemic recovery","volume":"40","author":"Lochner","year":"2006","journal-title":"J Pineal Res."},{"issue":"5","key":"10.1016\/j.jare.2020.09.007_b0190","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3349\/ymj.2008.49.5.735","article-title":"The effect of high dose melatonin on cardiac ischemia- reperfusion Injury","volume":"49","author":"Ceyran","year":"2008","journal-title":"Yonsei Med J."},{"key":"10.1016\/j.jare.2020.09.007_b0195","doi-asserted-by":"crossref","first-page":"41337","DOI":"10.1038\/srep41337","article-title":"Melatonin ameliorates myocardial ischemia\/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1alpha-SIRT3 signaling","volume":"7","author":"Yu","year":"2017","journal-title":"Sci Rep."},{"key":"10.1016\/j.jare.2020.09.007_b0200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s11658-016-0031-z","article-title":"p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation","volume":"21","author":"Liu","year":"2016","journal-title":"Cell Mol Biol Lett."},{"issue":"5","key":"10.1016\/j.jare.2020.09.007_b0205","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00395-019-0748-8","article-title":"Connexin 43 dephosphorylation contributes to arrhythmias and cardiomyocyte apoptosis in ischemia\/reperfusion hearts","volume":"114","author":"Xue","year":"2019","journal-title":"Basic Res Cardiol."},{"issue":"4","key":"10.1016\/j.jare.2020.09.007_b0210","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12605","article-title":"Melatonin receptor activation protects against low potassium-induced ventricular fibrillation by preserving action potentials and connexin-43 topology in isolated rat hearts","volume":"67","author":"Prado","year":"2019","journal-title":"J Pineal Res."},{"issue":"4","key":"10.1016\/j.jare.2020.09.007_b0215","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/jpi.12175","article-title":"A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases","volume":"57","author":"Yang","year":"2014","journal-title":"J Pineal Res."},{"key":"10.1016\/j.jare.2020.09.007_b0220","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/978-3-319-55330-6_10","article-title":"Functional Role of Mitochondria in Arrhythmogenesis","volume":"982","author":"Gambardella","year":"2017","journal-title":"Adv Exp Med Biol."},{"issue":"6","key":"10.1016\/j.jare.2020.09.007_b0225","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2217\/fca.12.58","article-title":"Mitochondrial membrane permeabilization and cell death during myocardial infarction: roles of calcium and reactive oxygen species","volume":"8","author":"Webster","year":"2012","journal-title":"Future Cardiol."},{"issue":"1038","key":"10.1016\/j.jare.2020.09.007_b0230","article-title":"Role of the Extracellular Signal-Regulated Kinase 1\/2 Signaling Pathway in Ischemia-Reperfusion Injury","volume":"10","author":"Kong","year":"2019","journal-title":"Front Physiol."},{"issue":"1","key":"10.1016\/j.jare.2020.09.007_b0235","doi-asserted-by":"crossref","DOI":"10.1007\/s00395-017-0662-x","article-title":"The RISK pathway and beyond","volume":"113","author":"Rossello","year":"2018","journal-title":"Basic Res Cardiol."},{"issue":"3\u20134","key":"10.1016\/j.jare.2020.09.007_b0240","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10741-007-9026-1","article-title":"Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection","volume":"12","author":"Hausenloy","year":"2007","journal-title":"Heart Fail Rev."},{"issue":"3","key":"10.1016\/j.jare.2020.09.007_b0245","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.biocel.2005.09.017","article-title":"Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection","volume":"38","author":"Davidson","year":"2006","journal-title":"Int J Biochem Cell Biol."},{"issue":"8","key":"10.1016\/j.jare.2020.09.007_b0250","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jacc.2005.01.021","article-title":"Failure to protect the myocardium against ischemia\/reperfusion injury after chronic atorvastatin treatment is recaptured by acute atorvastatin treatment: A potential role for phosphatase and tensin homolog deleted on chromosome ten?","volume":"45","author":"Mensah","year":"2005","journal-title":"J Am Coll Cardiol."},{"issue":"5","key":"10.1016\/j.jare.2020.09.007_b0255","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/01.CIR.103.5.670","article-title":"Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure","volume":"103","author":"Haq","year":"2001","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.jare.2020.09.007_b0260","doi-asserted-by":"crossref","first-page":"135","DOI":"10.5152\/eurasianjmed.2015.0267","article-title":"A Review of Melatonin, Its Receptors and Drugs","volume":"48","author":"Emet","year":"2016","journal-title":"The Eurasian journal of medicine."},{"key":"10.1016\/j.jare.2020.09.007_b0265","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-pharmtox-010814-124742","article-title":"MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective","volume":"56","author":"Liu","year":"2016","journal-title":"Annu Rev Pharmacol Toxicol."},{"issue":"3","key":"10.1016\/j.jare.2020.09.007_b0270","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/jpi.12312","article-title":"The nuclear melatonin receptor RORalpha is a novel endogenous defender against myocardial ischemia\/reperfusion injury","volume":"60","author":"He","year":"2016","journal-title":"J Pineal Res."}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123220302174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123220302174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T20:50:19Z","timestamp":1761857419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123220302174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":54,"alternative-id":["S2090123220302174"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2020.09.007","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin as a therapy in cardiac ischemia-reperfusion injury: Potential mechanisms by which MT2 activation mediates cardioprotection","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2020.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}