{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T02:37:03Z","timestamp":1794623823221,"version":"4.9.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31729004"],"award-info":[{"award-number":["31729004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002207"],"award-info":[{"award-number":["32002207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","award":["CARS-36"],"award-info":[{"award-number":["CARS-36"]}],"id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013807","name":"Wuhan University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jare.2021.11.009","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T12:00:17Z","timestamp":1637755217000},"page":"1-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["Cross-tissue single-cell transcriptomic landscape reveals the key cell subtypes and their potential roles in the nutrient absorption and metabolism in dairy cattle"],"prefix":"10.1016","volume":"37","author":[{"given":"Jia-Jin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senlin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengfei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa G.","family":"Valencak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Zeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1554","key":"10.1016\/j.jare.2021.11.009_b0005","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1098\/rstb.2010.0149","article-title":"Food consumption trends and drivers","volume":"365","author":"Kearney","year":"2010","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"4","key":"10.1016\/j.jare.2021.11.009_b0010","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41558-021-01000-1","article-title":"Anthropogenic climate change has slowed global agricultural productivity growth","volume":"11","author":"Ortiz-Bobea","year":"2021","journal-title":"Nat Clim Change"},{"issue":"7","key":"10.1016\/j.jare.2021.11.009_b0015","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1017\/S1751731109991285","article-title":"Gene expression in the digestive tissues of ruminants and their relationships with feeding and digestive processes","volume":"4","author":"Connor","year":"2010","journal-title":"Animal"},{"key":"10.1016\/j.jare.2021.11.009_b0020","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1196\/annals.1419.022","article-title":"Plant cell wall breakdown by anaerobic microorganisms from the mammalian digestive tract","volume":"1125","author":"Flint","year":"2008","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"10.1016\/j.jare.2021.11.009_b0025","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.3168\/jds.S0022-0302(97)76074-0","article-title":"Relationship Between Fermentation Acid Production in the Rumen and the Requirement for Physically Effective Fiber","volume":"80","author":"Allen","year":"1997","journal-title":"J Dairy Sci"},{"key":"10.1016\/j.jare.2021.11.009_b0030","doi-asserted-by":"crossref","unstructured":"Sun HZ, Zhou M, Wang O, Chen Y, Liu JX, Guan LL. Multi-omics reveals functional genomic and metabolic mechanisms of milk production and quality in dairy cows. Bioinformatics 2020; 36:2530-2537.","DOI":"10.1093\/bioinformatics\/btz951"},{"issue":"6","key":"10.1016\/j.jare.2021.11.009_b0035","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41587-020-0465-8","article-title":"Systematic comparison of single-cell and single-nucleus RNA-sequencing methods","volume":"38","author":"Ding","year":"2020","journal-title":"Nat Biotechnol"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11434-014-0634-6","article-title":"Single cell sequencing: technique, application, and future development","volume":"60","author":"Xue","year":"2015","journal-title":"Sci Bull"},{"issue":"5","key":"10.1016\/j.jare.2021.11.009_b0045","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","article-title":"Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets","volume":"161","author":"Macosko","year":"2015","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.jare.2021.11.009_b0050","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jare.2021.11.009_b0055","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst"},{"issue":"12","key":"10.1016\/j.jare.2021.11.009_b0060","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat Methods"},{"issue":"5","key":"10.1016\/j.jare.2021.11.009_b0065","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"issue":"7745","key":"10.1016\/j.jare.2021.11.009_b0070","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","article-title":"The single-cell transcriptional landscape of mammalian organogenesis","volume":"566","author":"Cao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jare.2021.11.009_b0075","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1038\/s41467-019-11738-0","article-title":"Metabolic landscape of the tumor microenvironment at single cell resolution","volume":"10","author":"Xiao","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0080","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using Cell Chat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0085","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-020-02210-0","article-title":"Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs","volume":"21","author":"He","year":"2020","journal-title":"Genome Biol"},{"issue":"6446","key":"10.1016\/j.jare.2021.11.009_b0090","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav6202","article-title":"Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits","volume":"364","author":"Chen","year":"2019","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0095","doi-asserted-by":"crossref","DOI":"10.1186\/s40104-019-0314-0","article-title":"Protein profiles of enzymatically isolated rumen epithelium in sheep fed a fibrous diet","volume":"10","author":"Bond","year":"2019","journal-title":"J Anim Sci Biotechnol"},{"issue":"6","key":"10.1016\/j.jare.2021.11.009_b0100","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.jaci.2020.01.042","article-title":"Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis","volume":"145","author":"He","year":"2020","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.jare.2021.11.009_b0105","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.devcel.2020.11.002","article-title":"A single-cell transcriptomic atlas of human skin aging","volume":"56","author":"Zou","year":"2021","journal-title":"Dev Cell"},{"issue":"13","key":"10.1016\/j.jare.2021.11.009_b0110","doi-asserted-by":"crossref","first-page":"12732","DOI":"10.1074\/jbc.M411619200","article-title":"The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation","volume":"280","author":"Robitaille","year":"2005","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0115","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a002576","article-title":"Gap junctions","volume":"1","author":"Goodenough","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"9","key":"10.1016\/j.jare.2021.11.009_b0120","doi-asserted-by":"crossref","first-page":"7654","DOI":"10.3168\/jds.2016-10880","article-title":"Short communication: Initial evidence supporting existence of potential rumen epidermal stem and progenitor cells","volume":"99","author":"Yohe","year":"2016","journal-title":"J Dairy Sci"},{"issue":"5","key":"10.1016\/j.jare.2021.11.009_b0125","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.cell.2020.10.003","article-title":"Co-option of Neutrophil Fates by Tissue Environments","volume":"183","author":"Ballesteros","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jare.2021.11.009_b0130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jare.2017.11.004","article-title":"Arachidonic acid: Physiological roles and potential health benefits \u2013 A review","volume":"11","author":"Tallima","year":"2018","journal-title":"J Adv Res"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0135","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1146\/annurev.biochem.78.072407.102340","article-title":"The structural and biochemical foundations of thiamin biosynthesis","volume":"78","author":"Jurgenson","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jare.2021.11.009_b0140","article-title":"KEGG mapping tools for uncovering hidden features in biological data","author":"Kanehisa","year":"2021","journal-title":"Protein Sci"},{"issue":"2","key":"10.1016\/j.jare.2021.11.009_b0145","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.cell.2020.11.043","article-title":"Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates","volume":"184","author":"Wang","year":"2021","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jare.2021.11.009_b0150","doi-asserted-by":"crossref","first-page":"G1098","DOI":"10.1152\/ajpgi.90442.2008","article-title":"Bicarbonate-dependent and bicarbonate-independent mechanisms contribute to nondiffusive uptake of acetate in the ruminal epithelium of sheep","volume":"296","author":"Aschenbach","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"10.1016\/j.jare.2021.11.009_b0155","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1017\/S0022029920000369","article-title":"Ruminal epithelium: A checkpoint for cattle health","volume":"87","author":"Baaske","year":"2020","journal-title":"J Dairy Res"},{"key":"10.1016\/j.jare.2021.11.009_b0160","doi-asserted-by":"crossref","unstructured":"Xiang R, Oddy VH, Archibald AL, Vercoe PE, Dalrymple BP. Epithelial, metabolic and innate immunity transcriptomic signatures differentiating the rumen from other sheep and mammalian gastrointestinal tract tissues. PeerJ 2016; 4:e1762.","DOI":"10.7717\/peerj.1762"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0165","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03751-6","article-title":"Massive mining of publicly available RNA-seq data from human and mouse","volume":"9","author":"Lachmann","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0170","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1079\/AHRR200237","article-title":"Transfer of energy substrates across the ruminal epithelium: implications and limitations","volume":"3","author":"G\u00e4bel","year":"2002","journal-title":"Anim Health Res Rev"},{"issue":"12","key":"10.1016\/j.jare.2021.11.009_b0175","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/iub.400","article-title":"Gluconeogenesis in dairy cows: the secret of making sweet milk from sour dough","volume":"62","author":"Aschenbach","year":"2010","journal-title":"IUBMB Life"},{"issue":"3","key":"10.1016\/j.jare.2021.11.009_b0180","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.cell.2020.06.014","article-title":"Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy","volume":"182","author":"Wu","year":"2020","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jare.2021.11.009_b0185","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.immuni.2016.02.007","article-title":"Intestinal interleukin-17 receptor signaling mediates reciprocal control of the gut microbiota and autoimmune inflammation","volume":"44","author":"Kumar","year":"2016","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jare.2021.11.009_b0190","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.it.2017.01.006","article-title":"IL-17 Signaling: The Yin and the Yang","volume":"38","author":"Amatya","year":"2017","journal-title":"Trends Immunol"},{"issue":"5","key":"10.1016\/j.jare.2021.11.009_b0195","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1101\/gr.250704.119","article-title":"Comprehensive analyses of 723 transcriptomes enhance genetic and biological interpretations for complex traits in cattle","volume":"30","author":"Fang","year":"2020","journal-title":"Genome Res"},{"key":"10.1016\/j.jare.2021.11.009_b0200","doi-asserted-by":"crossref","unstructured":"Amatschek S, Kriehuber E, Bauer W, Reininger B, Meraner P, Wolpl A, et al. Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environment. Blood 2007; 109:4777-4785.","DOI":"10.1182\/blood-2006-10-053280"},{"issue":"4","key":"10.1016\/j.jare.2021.11.009_b0205","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/eji.200323710","article-title":"Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs","volume":"33","author":"Storset","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jare.2021.11.009_b0210","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/s41467-017-02001-5","article-title":"Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing","volume":"8","author":"Bach","year":"2017","journal-title":"Nat Commun"},{"issue":"10","key":"10.1016\/j.jare.2021.11.009_b0215","doi-asserted-by":"crossref","first-page":"108819","DOI":"10.1016\/j.celrep.2021.108819","article-title":"Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution","volume":"34","author":"Busslinger","year":"2021","journal-title":"Cell Rep"},{"issue":"11","key":"10.1016\/j.jare.2021.11.009_b0220","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s41422-020-0374-x","article-title":"Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma","volume":"30","author":"Chen","year":"2020","journal-title":"Cell Res"},{"key":"10.1016\/j.jare.2021.11.009_b0225","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1177\/1753425912446954","article-title":"Classically or alternatively activated bovine monocyte-derived macrophages in vitro do not resemble CD163\/Calprotectin biased macrophage populations in the teat","volume":"18","author":"Duvel","year":"2012","journal-title":"Innate Immun"},{"issue":"7","key":"10.1016\/j.jare.2021.11.009_b0230","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/ni.3445","article-title":"Immunological Genome Project C. Expression profiling of constitutive mast cells reveals a unique identity within the immune system","volume":"17","author":"Dwyer","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jare.2021.11.009_b0235","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fvets.2017.00112","article-title":"Dairy Cows Naturally Infected with Bovine Leukemia Virus Exhibit Abnormal B- and T-Cell Phenotypes after Primary and Secondary Exposures to Keyhole Limpet Hemocyanin","volume":"4","author":"Frie","year":"2017","journal-title":"Front Vet Sci"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0240","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/imm.12708","article-title":"Frequency and phenotype of natural killer cells and natural killer cell subsets in bovine lymphoid compartments and blood","volume":"151","author":"Hamilton","year":"2017","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0245","doi-asserted-by":"crossref","DOI":"10.1186\/s13567-018-0547-5","article-title":"Development of in vitro enteroids derived from bovine small intestinal crypts","volume":"49","author":"Hamilton","year":"2018","journal-title":"Vet Res"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0250","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-018-1426-0","article-title":"Mapping human pluripotent stem cell differentiation pathways using high throughput single-cell RNA-sequencing","volume":"19","author":"Han","year":"2018","journal-title":"Genome Biol"},{"issue":"5","key":"10.1016\/j.jare.2021.11.009_b0255","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.cell.2018.02.001","article-title":"Mapping the Mouse Cell Atlas by Microwell-Seq","volume":"172","author":"Han","year":"2018","journal-title":"Cell"},{"issue":"7808","key":"10.1016\/j.jare.2021.11.009_b0260","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-2157-4","article-title":"Construction of a human cell landscape at single-cell level","volume":"581","author":"Han","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jare.2021.11.009_b0265","doi-asserted-by":"crossref","unstructured":"Hauser BR, Aure MH, Kelly MC, Genomics, Computational Biology C, Hoffman MP, et al. Generation of a Single-Cell RNAseq Atlas of Murine Salivary Gland Development. iScience 2020; 23:101838.","DOI":"10.1016\/j.isci.2020.101838"},{"issue":"45","key":"10.1016\/j.jare.2021.11.009_b0270","doi-asserted-by":"crossref","first-page":"35047","DOI":"10.1074\/jbc.M110.164541","article-title":"Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum","volume":"285","author":"Horst","year":"2010","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.jare.2021.11.009_b0275","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.cell.2019.10.027","article-title":"Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways","volume":"179","author":"Huang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jare.2021.11.009_b0280","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.3389\/fimmu.2017.01875","article-title":"Heterogeneity of Bovine Peripheral Blood Monocytes","volume":"8","author":"Hussen","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jare.2021.11.009_b0285","doi-asserted-by":"crossref","unstructured":"Liu Z, Jin YQ, Chen L, Wang Y, Yang X, Cheng J, et al. Specific marker expression and cell state of Schwann cells during culture in vitro. PLoS One 2015; 10:e0123278.","DOI":"10.1371\/journal.pone.0123278"},{"issue":"5","key":"10.1016\/j.jare.2021.11.009_b0290","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.cell.2020.02.008","article-title":"Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging","volume":"180","author":"Ma","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0295","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2021.11.009_b0300","doi-asserted-by":"crossref","first-page":"11906","DOI":"10.1073\/pnas.1818488116","article-title":"Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVdelta1 and TCRVdelta2 gammadelta T lymphocytes","volume":"116","author":"Pizzolato","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2748","key":"10.1016\/j.jare.2021.11.009_b0305","article-title":"Distinct Features of Canine Non-conventional CD4(-)CD8alpha(-) Double-Negative TCRalphabeta(+) vs","volume":"10","author":"Rabiger","year":"2019","journal-title":"TCRgammadelta(+) T Cells. Front Immunol"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0310","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-02289-3","article-title":"Estimation of immune cell content in tumour tissue using single-cell RNA-seq data","volume":"8","author":"Schelker","year":"2017","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.jare.2021.11.009_b0315","doi-asserted-by":"crossref","DOI":"10.1177\/1759091414548916","article-title":"MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells","volume":"6","author":"Schmid","year":"2014","journal-title":"ASN Neuro"},{"key":"10.1016\/j.jare.2021.11.009_b0320","doi-asserted-by":"crossref","unstructured":"Talker SC, Baumann A, Barut GT, Keller I, Bruggmann R, Summerfield A. Precise Delineation and Transcriptional Characterization of Bovine Blood Dendritic-Cell and Monocyte Subsets. Front Immunol 2018; 9:2505.","DOI":"10.3389\/fimmu.2018.02505"},{"issue":"6335","key":"10.1016\/j.jare.2021.11.009_b0325","doi-asserted-by":"crossref","DOI":"10.1126\/science.aah4573","article-title":"Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors","volume":"356","author":"Villani","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jare.2021.11.009_b0330","doi-asserted-by":"crossref","unstructured":"Wang Y, Song W, Wang J, Wang T, Xiong X, Qi Z, et al. Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. J Exp Med 2020; 217: e20191130.","DOI":"10.1084\/jem.20191130"},{"issue":"6402","key":"10.1016\/j.jare.2021.11.009_b0335","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1126\/science.aat1699","article-title":"Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors","volume":"361","author":"Young","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jare.2021.11.009_b0340","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1242\/dev.124891","article-title":"Stomach development, stem cells and disease","volume":"143","author":"Kim","year":"2016","journal-title":"Development"},{"issue":"6","key":"10.1016\/j.jare.2021.11.009_b0345","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.3168\/jds.2015-10351","article-title":"Development and physiology of the rumen and the lower gut: Targets for improving gut health","volume":"99","author":"Steele","year":"2016","journal-title":"J Dairy Sci"},{"issue":"3","key":"10.1016\/j.jare.2021.11.009_b0350","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.cell.2015.07.022","article-title":"A Call for Systematic Research on Solute Carriers","volume":"162","author":"C\u00e9sar-Razquin","year":"2015","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.jare.2021.11.009_b0355","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1152\/physiolgenomics.00058.2019","article-title":"Profiling solute-carrier transporters in key metabolic tissues during the postpartum evolution of mammary epithelial cells from nonsecretory to secretory","volume":"51","author":"Patel","year":"2019","journal-title":"Physiol Genomics"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0360","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3168\/jds.2020-19092","article-title":"Effects of a proinflammatory response on metabolic function of cultured, primary ruminal epithelial cells","volume":"104","author":"Kent-Dennis","year":"2021","journal-title":"J Dairy Sci"},{"issue":"4","key":"10.1016\/j.jare.2021.11.009_b0365","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00424-017-2105-9","article-title":"A look at the smelly side of physiology: transport of short chain fatty acids","volume":"470","author":"Stumpff","year":"2018","journal-title":"Pfl\u00fcgers Arch"},{"issue":"eaba8310","key":"10.1016\/j.jare.2021.11.009_b0370","article-title":"gammadelta T cells regulate the intestinal response to nutrient sensing","volume":"371","author":"Sullivan","year":"2021","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.jare.2021.11.009_b0375","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nri2586","article-title":"Structure and signalling in the IL-17 receptor family","volume":"9","author":"Gaffen","year":"2009","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10.1016\/j.jare.2021.11.009_b0380","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cvfa.2019.08.006","article-title":"Mucosal Immune System of Cattle: All Immune Responses Begin Here","volume":"35","author":"Chase","year":"2019","journal-title":"Vet Clin North Am Food Anim Pract"},{"issue":"1","key":"10.1016\/j.jare.2021.11.009_b0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11427-020-1828-8","article-title":"Modes of genetic adaptations underlying functional innovations in the rumen","volume":"64","author":"Pan","year":"2021","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.jare.2021.11.009_b0390","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.3389\/fimmu.2018.01270","article-title":"Cytokine Tuning of Intestinal Epithelial Function","volume":"9","author":"Andrews","year":"2018","journal-title":"Front Immunol"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123221002289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123221002289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:46:26Z","timestamp":1762598786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123221002289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":78,"alternative-id":["S2090123221002289"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2021.11.009","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cross-tissue single-cell transcriptomic landscape reveals the key cell subtypes and their potential roles in the nutrient absorption and metabolism in dairy cattle","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2021.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}