{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:26:03Z","timestamp":1792599963560,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMU-KI109003"],"award-info":[{"award-number":["KMU-KI109003"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["CA-110-PP-23"],"award-info":[{"award-number":["CA-110-PP-23"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["107-2314-B-400-036-MY3"],"award-info":[{"award-number":["107-2314-B-400-036-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jare.2022.03.005","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T11:31:05Z","timestamp":1647084665000},"page":"45-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["TRPM1 promotes tumor progression in acral melanoma by activating the Ca2+\/CaMKII\u03b4\/AKT pathway"],"prefix":"10.1016","volume":"43","author":[{"given":"Chi-Che","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Chiu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Ying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamichi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kaku-Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Tsung","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Tzong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daw-Yang","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Hung","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jare.2022.03.005_b0005","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/path.5213","article-title":"Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilities","volume":"247","author":"Rabbie","year":"2019","journal-title":"J Pathol"},{"key":"10.1016\/j.jare.2022.03.005_b0010","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jss.2020.02.010","article-title":"Acral Lentiginous Melanoma: Incidence and Survival in the United States, 2006\u20132015, an Analysis of the SEER Registry","volume":"251","author":"Huang","year":"2020","journal-title":"J Surg Res"},{"issue":"7653","key":"10.1016\/j.jare.2022.03.005_b0015","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature22071","article-title":"Whole-genome landscapes of major melanoma subtypes","volume":"545","author":"Hayward","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jare.2022.03.005_b0020","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/jid.2009.177","article-title":"Understanding melanoma signaling networks as the basis for molecular targeted therapy","volume":"130","author":"Smalley","year":"2010","journal-title":"J Invest Dermatol"},{"issue":"7","key":"10.1016\/j.jare.2022.03.005_b0025","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.cell.2015.05.044","article-title":"Genomic Classification of Cutaneous Melanoma","volume":"161","author":"Akbani","year":"2015","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jare.2022.03.005_b0030","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0092-8674(04)00215-6","article-title":"Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF","volume":"116","author":"Wan","year":"2004","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.jare.2022.03.005_b0035","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrclinonc.2017.43","article-title":"Targeted agents and immunotherapies: optimizing outcomes in melanoma","volume":"14","author":"Luke","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"issue":"3","key":"10.1016\/j.jare.2022.03.005_b0040","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3390\/jcm9030690","article-title":"Immunohistochemical BRAF V600E Expression and Intratumor BRAF V600E Heterogeneity in Acral Melanoma: Implication in Melanoma-Specific Survival","volume":"9","author":"Ito","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.jare.2022.03.005_b0045","doi-asserted-by":"crossref","unstructured":"Dika E, Veronesi G, Altimari A, Riefolo M, Ravaioli GM, Piraccini BM, et al. BRAF, KIT, and NRAS Mutations of Acral Melanoma in White Patients. Am J Clin Pathol. 2020;153(5):664-71.","DOI":"10.1093\/ajcp\/aqz209"},{"issue":"1","key":"10.1016\/j.jare.2022.03.005_b0050","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18988-3","article-title":"Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity","volume":"11","author":"Newell","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2022.03.005_b0055","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/geno.1998.5549","article-title":"Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1)","volume":"54","author":"Hunter","year":"1998","journal-title":"Genomics"},{"issue":"2","key":"10.1016\/j.jare.2022.03.005_b0060","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1158\/0008-5472.CAN-03-2440","article-title":"Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma","volume":"64","author":"Miller","year":"2004","journal-title":"Cancer Res"},{"issue":"11","key":"10.1016\/j.jare.2022.03.005_b0065","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0046-8177(00)80003-9","article-title":"Patterns of melastatin mRNA expression in melanocytic tumors","volume":"31","author":"Deeds","year":"2000","journal-title":"Hum Pathol"},{"issue":"9","key":"10.1016\/j.jare.2022.03.005_b0070","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1600-0625.2012.01565.x","article-title":"Role of TRPM in melanocytes and melanoma","volume":"21","author":"Guo","year":"2012","journal-title":"Exp Dermatol"},{"issue":"7","key":"10.1016\/j.jare.2022.03.005_b0075","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/modpathol.2009.56","article-title":"TRPM1 (Melastatin-1\/MLSN1) mRNA expression in Spitz nevi and nodular melanomas","volume":"22","author":"Erickson","year":"2009","journal-title":"Mod Pathol"},{"issue":"5","key":"10.1016\/j.jare.2022.03.005_b0080","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.molcel.2010.11.020","article-title":"Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma","volume":"40","author":"Levy","year":"2010","journal-title":"Mol Cell"},{"issue":"29","key":"10.1016\/j.jare.2022.03.005_b0085","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1705206114","article-title":"BRAF(V600) inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells","volume":"114","author":"Lunavat","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.jare.2022.03.005_b0090","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrg3185","article-title":"Insights into the regulation of protein abundance from proteomic and transcriptomic analyses","volume":"13","author":"Vogel","year":"2012","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jare.2022.03.005_b0095","doi-asserted-by":"crossref","first-page":"24799","DOI":"10.1038\/srep24799","article-title":"Cross-tissue Analysis of Gene and Protein Expression in Normal and Cancer Tissues","volume":"6","author":"Kosti","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jare.2022.03.005_b0100","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2016.03.014","article-title":"On the Dependency of Cellular Protein Levels on mRNA Abundance","volume":"165","author":"Liu","year":"2016","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.jare.2022.03.005_b0105","first-page":"2604","article-title":"TRPM Channels in Human Diseases","volume":"9","author":"Jimenez","year":"2020","journal-title":"TRPM Channels in Human Diseases Cells"},{"issue":"19","key":"10.1016\/j.jare.2022.03.005_b0110","doi-asserted-by":"crossref","first-page":"10692","DOI":"10.1073\/pnas.191360198","article-title":"Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform","volume":"98","author":"Xu","year":"2001","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.jare.2022.03.005_b0115","doi-asserted-by":"crossref","first-page":"C679","DOI":"10.1152\/ajpcell.00092.2009","article-title":"Calcium homeostasis in human melanocytes: role of transient receptor potential melastatin 1 (TRPM1) and its regulation by ultraviolet light","volume":"297","author":"Devi","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"10.1016\/j.jare.2022.03.005_b0120","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00008390-200206000-00004","article-title":"Changes in the motility of B16F10 melanoma cells induced by alterations in resting calcium influx","volume":"12","author":"Cox","year":"2002","journal-title":"Melanoma Res"},{"issue":"5","key":"10.1016\/j.jare.2022.03.005_b0125","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.cell.2005.11.017","article-title":"CaMKII structure\u2013an elegant design","volume":"123","author":"Hunter","year":"2005","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jare.2022.03.005_b0130","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.cell.2011.07.038","article-title":"A mechanism for tunable autoinhibition in the structure of a human Ca2+\/calmodulin- dependent kinase II holoenzyme","volume":"146","author":"Chao","year":"2011","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jare.2022.03.005_b0135","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1074\/jbc.R000013200","article-title":"Cellular signaling through multifunctional Ca2+\/calmodulin-dependent protein kinase II","volume":"276","author":"Soderling","year":"2001","journal-title":"J Biol Chem"},{"issue":"7","key":"10.1016\/j.jare.2022.03.005_b0140","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.jmb.2019.02.001","article-title":"The KN-93 Molecule Inhibits Calcium\/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca(2+)\/CaM","volume":"431","author":"Wong","year":"2019","journal-title":"J Mol Biol"},{"issue":"3","key":"10.1016\/j.jare.2022.03.005_b0145","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/sj.bjc.6606072","article-title":"Polyclonality of BRAF mutations in primary melanoma and the selection of mutant alleles during progression","volume":"104","author":"Lin","year":"2011","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.jare.2022.03.005_b0150","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1073\/pnas.0912730107","article-title":"TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade","volume":"107","author":"Koike","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"41","key":"10.1016\/j.jare.2022.03.005_b0155","doi-asserted-by":"crossref","first-page":"9889","DOI":"10.1523\/JNEUROSCI.0824-17.2017","article-title":"The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit","volume":"37","author":"Kozuka","year":"2017","journal-title":"J Neurosci"},{"issue":"45","key":"10.1016\/j.jare.2022.03.005_b0160","doi-asserted-by":"crossref","first-page":"19174","DOI":"10.1073\/pnas.0908711106","article-title":"TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells","volume":"106","author":"Morgans","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.jare.2022.03.005_b0165","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-021-00751-5","article-title":"AUY922 induces retinal toxicity through attenuating TRPM1","volume":"28","author":"Shen","year":"2021","journal-title":"J Biomed Sci"},{"issue":"17","key":"10.1016\/j.jare.2022.03.005_b0170","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1007\/s00018-008-8086-2","article-title":"Ca(2+)\/calmodulin-dependent protein kinases","volume":"65","author":"Swulius","year":"2008","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"10.1016\/j.jare.2022.03.005_b0175","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.molcel.2017.05.028","article-title":"Intracellular Ca(2+) Sensing: Its Role in Calcium Homeostasis and Signaling","volume":"66","author":"Bagur","year":"2017","journal-title":"Mol Cell"},{"issue":"6","key":"10.1016\/j.jare.2022.03.005_b0180","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-2553-6","article-title":"CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis"},{"issue":"5","key":"10.1016\/j.jare.2022.03.005_b0185","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.3892\/mmr.2014.2525","article-title":"Calcium\/calmodulindependent protein kinase II enhances metastasis of human gastric cancer by upregulating nuclear factorkappaB and Aktmediated matrix metalloproteinase9 production","volume":"10","author":"Liu","year":"2014","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.jare.2022.03.005_b0190","doi-asserted-by":"crossref","DOI":"10.1038\/srep33132","article-title":"Phosphorylation of calcium\/calmodulin-stimulated protein kinase II at T286 enhances invasion and migration of human breast cancer cells","volume":"6","author":"Chi","year":"2016","journal-title":"Sci Rep"},{"issue":"33","key":"10.1016\/j.jare.2022.03.005_b0195","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.3748\/wjg.v23.i33.6111","article-title":"Ca(2+)\/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1\/2 and p38 pathways","volume":"23","author":"Chen","year":"2017","journal-title":"World J Gastroenterol"},{"issue":"24","key":"10.1016\/j.jare.2022.03.005_b0200","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1182\/blood-2012-06-434894","article-title":"CaMKII gamma, a critical regulator of CML stem\/progenitor cells, is a target of the natural product berbamine","volume":"120","author":"Gu","year":"2012","journal-title":"Blood"},{"issue":"18","key":"10.1016\/j.jare.2022.03.005_b0205","doi-asserted-by":"crossref","first-page":"16069","DOI":"10.18632\/oncotarget.3866","article-title":"Ca2+\/calmodulin-dependent protein kinase IIgamma enhances stem-like traits and tumorigenicity of lung cancer cells","volume":"6","author":"Chai","year":"2015","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.jare.2022.03.005_b0210","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1172\/JCI73411","article-title":"CaMK4-dependent activation of AKT\/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance","volume":"124","author":"Koga","year":"2014","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.jare.2022.03.005_b0215","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/art.30085","article-title":"Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium\/calmodulin-dependent protein kinase type IV","volume":"63","author":"Ichinose","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jare.2022.03.005_b0220","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.lfs.2019.01.010","article-title":"Chronic CaMKII inhibition reverses cardiac function and cardiac reserve in HF mice","volume":"219","author":"He","year":"2019","journal-title":"Life Sci"},{"issue":"9","key":"10.1016\/j.jare.2022.03.005_b0225","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/labinvest.3700658","article-title":"alpha-CaMKII controls the growth of human osteosarcoma by regulating cell cycle progression","volume":"87","author":"Yuan","year":"2007","journal-title":"Lab Invest"},{"issue":"11","key":"10.1016\/j.jare.2022.03.005_b0230","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0161-5890(00)00087-0","article-title":"Calcium-induced ERK activation in human T lymphocytes occurs via p56(Lck) and CaM-kinase","volume":"37","author":"Franklin","year":"2000","journal-title":"Mol Immunol"},{"issue":"Pt 11","key":"10.1016\/j.jare.2022.03.005_b0235","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1113\/jphysiol.2008.165258","article-title":"Activation by Ca2+\/calmodulin of an exogenous myosin light chain kinase in mouse arteries","volume":"587","author":"Raina","year":"2009","journal-title":"J Physiol"},{"issue":"3","key":"10.1016\/j.jare.2022.03.005_b0240","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0022-3565(24)37893-0","article-title":"KN-93, an inhibitor of multifunctional Ca++\/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart","volume":"287","author":"Anderson","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"issue":"38","key":"10.1016\/j.jare.2022.03.005_b0245","doi-asserted-by":"crossref","first-page":"35061","DOI":"10.1074\/jbc.M202928200","article-title":"Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+\/calmodulin-dependent protein kinase II antagonism","volume":"277","author":"Smyth","year":"2002","journal-title":"The Journal of biological chemistry"},{"issue":"2","key":"10.1016\/j.jare.2022.03.005_b0250","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3390\/ijms22020976","article-title":"NECTIN4: A Novel Therapeutic Target for Melanoma","volume":"22","author":"Tanaka","year":"2021","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123222000662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123222000662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:51:00Z","timestamp":1778835060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123222000662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":50,"alternative-id":["S2090123222000662"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2022.03.005","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRPM1 promotes tumor progression in acral melanoma by activating the Ca2+\/CaMKII\u03b4\/AKT pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2022.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}