{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T06:39:54Z","timestamp":1770791994993,"version":"3.50.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2017ZX10202102"],"award-info":[{"award-number":["2017ZX10202102"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2017ZX10304402\u2013002-007"],"award-info":[{"award-number":["2017ZX10304402\u2013002-007"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008100","name":"Southern University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008100","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1303402"],"award-info":[{"award-number":["2016YFC1303402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014137","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC12018112"],"award-info":[{"award-number":["SHDC12018112"]}],"id":[{"id":"10.13039\/501100014137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014137","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2020CR3002A"],"award-info":[{"award-number":["SHDC2020CR3002A"]}],"id":[{"id":"10.13039\/501100014137","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jare.2022.08.008","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T22:25:47Z","timestamp":1660947947000},"page":"163-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Rapid generation of a mouse model for evaluating on-target normal tissue toxicity of human CAR-T cells using replication-defective recombinant adenovirus"],"prefix":"10.1016","volume":"47","author":[{"given":"Qibin","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoqun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuisong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiqi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangqing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongxun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jare.2022.08.008_b0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nchembio.2565","article-title":"Rewiring T-cell responses to soluble factors with chimeric antigen receptors","volume":"14","author":"Chang","year":"2018","journal-title":"Nat Chem Biol"},{"issue":"1","key":"10.1016\/j.jare.2022.08.008_b0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/cancers11010047","article-title":"Chimeric antigen receptor T-cell (CAR T) therapy for hematologic and solid malignancies: efficacy and safety-a systematic review with meta-analysis","volume":"11","author":"Yu","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"13","key":"10.1016\/j.jare.2022.08.008_b0015","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1200\/JCO.2006.05.9964","article-title":"Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience","volume":"24","author":"Lamers","year":"2006","journal-title":"JCO"},{"issue":"4","key":"10.1016\/j.jare.2022.08.008_b0020","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/mt.2010.24","article-title":"Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2","volume":"18","author":"Morgan","year":"2010","journal-title":"Mol Ther"},{"issue":"10","key":"10.1016\/j.jare.2022.08.008_b0025","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1154","article-title":"Severe delayed pulmonary toxicity following PD-L1-specific CAR-T cell therapy for non-small cell lung cancer","volume":"9","author":"Liu","year":"2020","journal-title":"Clin Transl Immunology"},{"key":"10.1016\/j.jare.2022.08.008_b0030","doi-asserted-by":"crossref","unstructured":"U.S. Department of Health and Human Services, Food and Drug Administration, Center for Biologics Evaluation and Research. Guidance for human somatic cell therapy and gene therapy, Hum Gene Ther, 12(3) (2001), pp. 303-314. doi: 10.1089\/10430340150218431.","DOI":"10.1089\/10430340150218431"},{"issue":"5","key":"10.1016\/j.jare.2022.08.008_b0035","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/mt.2012.73","article-title":"Human tumor xenografts: the good, the bad, and the ugly","volume":"20","author":"Morgan","year":"2012","journal-title":"Mol Ther"},{"key":"10.1016\/j.jare.2022.08.008_b0040","doi-asserted-by":"crossref","unstructured":"Liu X, Jiang S, Fang C, Yang S, Olalere D, Pequignot EC, et al. Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice. Cancer Res 75(17) (2015), pp. 3596-3607. doi: 10.1158\/0008-5472.CAN-15-0159.","DOI":"10.1158\/0008-5472.CAN-15-0159"},{"issue":"17","key":"10.1016\/j.jare.2022.08.008_b0045","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1158\/0008-5472.CAN-15-0139","article-title":"Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent antitumor activity","volume":"75","author":"Caruso","year":"2015","journal-title":"Cancer Res"},{"issue":"14","key":"10.1016\/j.jare.2022.08.008_b0050","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.136012","article-title":"A rational mouse model to detect on-target, off-tumor CAR T cell toxicity","volume":"5","author":"Castellarin","year":"2020","journal-title":"JCI Insight"},{"issue":"S1","key":"10.1016\/j.jare.2022.08.008_b0055","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1002\/jgm.496","article-title":"Adenoviral vectors for gene transfer and therapy","volume":"6","author":"Volpers","year":"2004","journal-title":"J Gene Med"},{"issue":"13","key":"10.1016\/j.jare.2022.08.008_b0060","doi-asserted-by":"crossref","first-page":"4970","DOI":"10.1073\/pnas.1323279111","article-title":"Rapid generation of a mouse model for Middle East respiratory syndrome","volume":"111","author":"Zhao","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.jare.2022.08.008_b0065","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.cell.2020.06.010","article-title":"Generation of a broadly useful model for COVID-19 pathogenesis, vaccination, and treatment","volume":"182","author":"Sun","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jare.2022.08.008_b0070","doi-asserted-by":"crossref","DOI":"10.1038\/srep39833","article-title":"An oxygen sensitive self-decision making engineered CAR T-cell","volume":"7","author":"Juillerat","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jare.2022.08.008_b0075","doi-asserted-by":"crossref","DOI":"10.1186\/s40364-020-00238-9","article-title":"Engineering T cells with hypoxia-inducible chimeric antigen receptor (HiCAR) for selective tumor killing","volume":"8","author":"Liao","year":"2020","journal-title":"Biomark Res"},{"issue":"4","key":"10.1016\/j.jare.2022.08.008_b0080","doi-asserted-by":"crossref","first-page":"100227","DOI":"10.1016\/j.xcrm.2021.100227","article-title":"Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors","volume":"2","author":"Kosti","year":"2021","journal-title":"Cell Rep Med"},{"issue":"1","key":"10.1016\/j.jare.2022.08.008_b0085","doi-asserted-by":"crossref","DOI":"10.1186\/s40364-020-00237-w","article-title":"PD-L1 chimeric costimulatory receptor improves the efficacy of CAR-T cells for PD-L1-positive solid tumors and reduces toxicity in vivo","volume":"8","author":"Liao","year":"2020","journal-title":"Biomark Res"},{"issue":"5","key":"10.1016\/j.jare.2022.08.008_b0090","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J Immunol"},{"issue":"9","key":"10.1016\/j.jare.2022.08.008_b0095","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.3390\/ijms19092564","article-title":"Tracking of adipose-derived mesenchymal stromal\/stem cells in a model of cisplatin-induced acute kidney injury: comparison of bioluminescence imaging versus qRT-PCR","volume":"19","author":"Schubert","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.jare.2022.08.008_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/cancers9100139","article-title":"CD47-CAR-T cells effectively kill target cancer cells and block pancreatic tumor growth","volume":"9","author":"Golubovskaya","year":"2017","journal-title":"Cancers (Basel)"},{"issue":"12","key":"10.1016\/j.jare.2022.08.008_b0105","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nrc2540","article-title":"The impact of O2 availability on human cancer","volume":"8","author":"Bertout","year":"2008","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10.1016\/j.jare.2022.08.008_b0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri981","article-title":"Hepatic T cells and liver tolerance","volume":"3","author":"Crispe","year":"2003","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.jare.2022.08.008_b0115","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ymthe.2003.10.010","article-title":"Ablating CAR and integrin binding in adenovirus vectors reduces nontarget organ transduction and permits sustained bloodstream persistence following intraperitoneal administration","volume":"9","author":"Akiyama","year":"2004","journal-title":"Mol Ther"},{"issue":"9","key":"10.1016\/j.jare.2022.08.008_b0120","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.tibtech.2015.06.009","article-title":"piggyBac-ing models and new therapeutic strategies","volume":"33","author":"Woodard","year":"2015","journal-title":"Trends Biotechnol"},{"issue":"8","key":"10.1016\/j.jare.2022.08.008_b0125","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/sj.gt.3302210","article-title":"Hydroporation as the mechanism of hydrodynamic delivery","volume":"11","author":"Zhang","year":"2004","journal-title":"Gene Ther"},{"key":"10.1016\/j.jare.2022.08.008_b0130","article-title":"Cloning and large-scale production of high-capacity adenoviral vectors based on the human adenovirus type 5","volume":"107","author":"Ehrke-Schulz","year":"2016","journal-title":"J Vis Exp"},{"issue":"7","key":"10.1016\/j.jare.2022.08.008_b0135","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/mt.2008.86","article-title":"Modification of adenoviral vectors with polyethylene glycol modulates in vivo tissue tropism and gene expression","volume":"16","author":"Hofherr","year":"2008","journal-title":"Mol Ther"},{"issue":"2","key":"10.1016\/j.jare.2022.08.008_b0140","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/156652309787909544","article-title":"Two key challenges for effective adenovirus-mediated liver gene therapy: innate immune responses and hepatocyte-specific transduction","volume":"9","author":"Descamps","year":"2009","journal-title":"Curr Gene Ther"},{"issue":"31","key":"10.1016\/j.jare.2022.08.008_b0145","doi-asserted-by":"crossref","first-page":"30675","DOI":"10.18632\/oncotarget.5169","article-title":"Progresses towards safe and efficient gene therapy vectors","volume":"6","author":"Chira","year":"2015","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.jare.2022.08.008_b0150","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cell.2016.01.011","article-title":"Precision tumor recognition by T cells with combinatorial antigen-sensing circuits","volume":"164","author":"Roybal","year":"2016","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jare.2022.08.008_b0155","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ymthe.2016.10.011","article-title":"Masked chimeric antigen receptor for tumor-specific activation","volume":"25","author":"Han","year":"2017","journal-title":"Mol Ther"},{"issue":"8","key":"10.1016\/j.jare.2022.08.008_b0160","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay9209","article-title":"Engineering light-controllable CAR T cells for cancer immunotherapy","volume":"6","author":"Huang","year":"2020","journal-title":"Sci Adv"},{"issue":"3","key":"10.1016\/j.jare.2022.08.008_b0165","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.jconrel.2012.05.035","article-title":"Site-specific targeting of antibody activity in vivo mediated by disease-associated proteases","volume":"161","author":"Erster","year":"2012","journal-title":"J Control Release"},{"issue":"12","key":"10.1016\/j.jare.2022.08.008_b0170","doi-asserted-by":"crossref","first-page":"108542","DOI":"10.1016\/j.celrep.2020.108542","article-title":"Exploitation of elevated extracellular ATP to specifically direct antibody to tumor microenvironment","volume":"33","author":"Mimoto","year":"2020","journal-title":"Cell Rep"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123222001898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123222001898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T20:56:32Z","timestamp":1761857792000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123222001898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":34,"alternative-id":["S2090123222001898"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2022.08.008","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid generation of a mouse model for evaluating on-target normal tissue toxicity of human CAR-T cells using replication-defective recombinant adenovirus","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2022.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}