{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:20:32Z","timestamp":1792592432874,"version":"4.5.0"},"reference-count":241,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874010"],"award-info":[{"award-number":["81874010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272554"],"award-info":[{"award-number":["82272554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC2009004"],"award-info":[{"award-number":["2020YFC2009004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2501700"],"award-info":[{"award-number":["2021YFC2501700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jare.2022.08.019","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T05:26:14Z","timestamp":1663219574000},"page":"63-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Pathophysiological mechanism of acute bone loss after fracture"],"prefix":"10.1016","volume":"49","author":[{"given":"Xuan-Qi","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-liang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Li","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jare.2022.08.019_b0005","doi-asserted-by":"crossref","DOI":"10.1359\/jbmr.2003.18.12.2083","article-title":"Disorders Associated with Acute Rapid and Severe Bone Loss","author":"Epstein","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0010","doi-asserted-by":"crossref","DOI":"10.1007\/s12018-018-9253-0","article-title":"Systemic Bone Loss After Fracture","author":"Osipov","year":"2018","journal-title":"Clin Rev Bone Miner Metab"},{"key":"10.1016\/j.jare.2022.08.019_b0015","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2016-210289","article-title":"EULAR\/EFORT recommendations for management of patients older than 50 years with a fragility fracture and prevention of subsequent fractures","author":"Lems","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2022.08.019_b0020","author":"Compston","year":"2019","journal-title":"Osteoporosis Lancet"},{"key":"10.1016\/j.jare.2022.08.019_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-8587(17)30188-2","article-title":"Osteoporosis treatment: recent developments and ongoing challenges","author":"Khosla","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jare.2022.08.019_b0030","article-title":"Treatment of low bone density or osteoporosis to prevent fractures in men and women: A clinical practice guideline update from the American college of physicians","author":"Qaseem","year":"2017","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jare.2022.08.019_b0035","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1359\/jbmr.1999.14.5.821","article-title":"Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures","volume":"14","author":"Black","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0040","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1359\/jbmr.2000.15.4.721","article-title":"Patients with prior fractures have an increased risk of future fractures: A summary of the literature and statistical synthesis","volume":"15","author":"Klotzbuecher","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0045","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.2106\/00004623-200310000-00011","article-title":"Colles fracture, spine fracture, and subsequent risk of hip fracture in men and women a meta-analysis","volume":"85","author":"Haentjens","year":"2003","journal-title":"J Bone Jt Surg - Ser A"},{"key":"10.1016\/j.jare.2022.08.019_b0050","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2106\/JBJS.G.01529","article-title":"Proximal humeral fracture as a risk factor for subsequent hip fractures","volume":"91","author":"Clinton","year":"2009","journal-title":"J Bone Jt Surg - Ser A"},{"key":"10.1016\/j.jare.2022.08.019_b0055","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.2106\/00004623-200209000-00004","article-title":"Refractures in patients at least forty-five years old: A prospective analysis of twenty-two thousand and sixty patients","volume":"84","author":"Robinson","year":"2002","journal-title":"J Bone Jt Surg - Ser A"},{"key":"10.1016\/j.jare.2022.08.019_b0060","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archinte.162.1.33","article-title":"Fractures between the ages of 20 and 50 years increase women\u2019s risk of subsequent fractures","volume":"162","author":"Wu","year":"2002","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jare.2022.08.019_b0065","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1007\/s00198-018-4606-6","article-title":"Incident fracture is associated with a period of accelerated loss of hip BMD: the Study of Osteoporotic Fractures","volume":"29","author":"Christiansen","year":"2018","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jare.2022.08.019_b0070","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jbmr.3579","article-title":"Age Dependence of Systemic Bone Loss and Recovery Following Femur Fracture in Mice","volume":"34","author":"Emami","year":"2019","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0075","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/jbmr.3924","article-title":"Deterioration of Cortical and Trabecular Microstructure Identifies Women With Osteopenia or Normal Bone Mineral Density at Imminent and Long-Term Risk for Fragility Fracture: A Prospective Study","volume":"35","author":"Chapurlat","year":"2020","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0080","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1152\/japplphysiol.00021.2014","article-title":"Bone loss patterns in cortical, subcortical, and trabecular compartments during simulated microgravity","volume":"117","author":"Cervinka","year":"2014","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b0085","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/cs0640537","article-title":"Vertebral bone loss: An unheeded side effect of therapeutic bed rest","volume":"64","author":"Krolner","year":"1983","journal-title":"Clin Sci"},{"key":"10.1016\/j.jare.2022.08.019_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(10)62289-1","article-title":"Vertebroplasty versus conservative treatment for vertebral fractures","author":"Denaro","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2022.08.019_b0095","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000337.pub2","article-title":"Conservative versus operative treatment for hip fractures in adults","author":"Handoll","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jare.2022.08.019_b0100","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.L.00183","article-title":"Plaster: Our orthopaedic heritage - AAOS exhibit selection","author":"DeMaio","year":"2012","journal-title":"J Bone Jt Surg - Ser A"},{"key":"10.1016\/j.jare.2022.08.019_b0105","doi-asserted-by":"crossref","DOI":"10.7748\/ns.23.51.49.s48","article-title":"Orthopaedic plaster casting: nurse and patient education","author":"Bakody","year":"2009","journal-title":"Nurs Stand"},{"key":"10.1016\/j.jare.2022.08.019_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbiomech.2009.09.016","article-title":"Boning up on Wolff\u2019s Law: Mechanical regulation of the cells that make and maintain bone","author":"Chen","year":"2010","journal-title":"J Biomech"},{"key":"10.1016\/j.jare.2022.08.019_b0115","doi-asserted-by":"crossref","DOI":"10.1002\/ajpa.20155","article-title":"The aging of Wolff\u2019s \u201claw\u201d: Ontogeny and responses to mechanical loading in cortical bone","author":"Pearson","year":"2004","journal-title":"Yearb Phys Anthropol"},{"key":"10.1016\/j.jare.2022.08.019_b0120","article-title":"update of bone physiology and Wolff s law for clinicians","volume":"2004","author":"Frost","year":"2003","journal-title":"Angle Orthod"},{"key":"10.1016\/j.jare.2022.08.019_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom10030432","article-title":"Interactions between muscle and bone\u2014where physics meets biology","volume":"10","author":"Herrmann","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.jare.2022.08.019_b0130","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11154-015-9313-4","article-title":"Physiological mechanisms and therapeutic potential of bone mechanosensing","volume":"16","author":"Xiao","year":"2015","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.jare.2022.08.019_b0135","article-title":"Disuse Osteoporosis: Clinical and Mechanistic Insights","author":"Rolvien","year":"2021","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jare.2022.08.019_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2008.10.044","article-title":"Recovery of muscle atrophy and bone loss from 90 days bed rest: Results from a one-year follow-up","author":"Rittweger","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.jare.2022.08.019_b0145","doi-asserted-by":"crossref","DOI":"10.3109\/17453670903486992","article-title":"Bone density of the femoral neck following Birmingham hip resurfacing","author":"Cooke","year":"2009","journal-title":"Acta Orthop"},{"key":"10.1016\/j.jare.2022.08.019_b0150","article-title":"Changes in bone mass and bone turnover following distal forearm fracture","author":"Ingle","year":"1999","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jare.2022.08.019_b0155","doi-asserted-by":"crossref","DOI":"10.2307\/2312521","article-title":"Mathematical Methods for Digital Computers","author":"Way","year":"1961","journal-title":"Am Math Mon"},{"key":"10.1016\/j.jare.2022.08.019_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.566346","article-title":"Mechano-Regulation of Trabecular Bone Adaptation Is Controlled by the Local in vivo Environment and Logarithmically Dependent on Loading Frequency","author":"Scheuren","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jare.2022.08.019_b0165","doi-asserted-by":"crossref","DOI":"10.1186\/s12938-016-0267-x","article-title":"Mathematically modeling fluid flow and fluid shear stress in the canaliculi of a loaded osteon","author":"Wu","year":"2016","journal-title":"Biomed Eng Online"},{"key":"10.1016\/j.jare.2022.08.019_b0170","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/jbmr.211","article-title":"Real-time measurement of solute transport within the lacunar-canalicular system of mechanically loaded bone: Direct evidence for load-induced fluid flow","volume":"26","author":"Price","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2020.103700","article-title":"Research on solute transport behaviors in the lacunar-canalicular system using numerical simulation in microgravity","volume":"119","author":"Liu","year":"2020","journal-title":"Comput Biol Med"},{"key":"10.1016\/j.jare.2022.08.019_b0180","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0700636104","article-title":"Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism","author":"Malone","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2022.08.019_b0185","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1002\/stem.1235","article-title":"Primary cilia-mediated mechanotransduction in human mesenchymal stem cells","volume":"30","author":"Hoey","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.jare.2022.08.019_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115346","article-title":"Primary cilia act as microgravity sensors by depolymerizing microtubules to inhibit osteoblastic differentiation and mineralization","volume":"136","author":"Shi","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.jare.2022.08.019_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.622822","article-title":"Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin Please","author":"Smith","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jare.2022.08.019_b0200","doi-asserted-by":"crossref","DOI":"10.1038\/s41594-020-0507-4","article-title":"The molecular structure of mammalian primary cilia revealed by cryo-electron tomography","author":"Kiesel","year":"2020","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.jare.2022.08.019_b0205","doi-asserted-by":"crossref","DOI":"10.1038\/s41580-018-0086-y","article-title":"Hippo\u2013YAP\/TAZ signalling in organ regeneration and regenerative medicine","author":"Moya","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jare.2022.08.019_b0210","doi-asserted-by":"crossref","DOI":"10.1038\/s41573-020-0070-z","article-title":"Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine","author":"Dey","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jare.2022.08.019_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcb.2019.10.005","article-title":"The Hippo Pathway, YAP\/TAZ, and the Plasma Membrane","author":"Rausch","year":"2020","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jare.2022.08.019_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2014.07.034","article-title":"Regulation of YAP by mechanical strain through Jnk and Hippo signaling","author":"Codelia","year":"2014","journal-title":"Curr Biol"},{"key":"10.1016\/j.jare.2022.08.019_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2013.07.042","article-title":"A mechanical checkpoint controls multicellular growth through YAP\/TAZ regulation by actin-processing factors","author":"Aragona","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jare.2022.08.019_b0230","doi-asserted-by":"crossref","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jare.2022.08.019_b0235","first-page":"1","article-title":"Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells via depolymerizing F-actin to impede TAZ nuclear translocation","volume":"6","author":"Chen","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jare.2022.08.019_b0240","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbrc.2015.11.006","article-title":"Simulated microgravity inhibits osteogenic differentiation of mesenchymal stem cells through down regulating the transcriptional co-activator TAZ","volume":"468","author":"Chen","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jare.2022.08.019_b0245","article-title":"Dedifferentiation by adenovirus E1A due to inactivation of hippo pathway effectors YAP and TAZ","author":"Zemke","year":"2019","journal-title":"Genes Dev"},{"key":"10.1016\/j.jare.2022.08.019_b0250","article-title":"Matrix stiffening by self-mineralizable guided bone regeneration","author":"Li","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jare.2022.08.019_b0255","doi-asserted-by":"crossref","DOI":"10.1038\/ng1916","article-title":"BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing","author":"Tsuji","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.jare.2022.08.019_b0260","doi-asserted-by":"crossref","DOI":"10.1038\/nrendo.2016.12","article-title":"BMP signalling in skeletal development, disease and repair","author":"Salazar","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jare.2022.08.019_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2020.07.015","article-title":"Heparan sulfate co-immobilized with cRGD ligands and BMP2 on biomimetic platforms promotes BMP2-mediated osteogenic differentiation","author":"Sefkow-Werner","year":"2020","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jare.2022.08.019_b0270","article-title":"The role of the micro-pattern and nano-topography of hydroxyapatite bioceramics on stimulating osteogenic differentiation of mesenchymal stem cells","author":"Zhao","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jare.2022.08.019_b0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/advs.201902931","article-title":"BMP-2 Signaling and Mechanotransduction Synergize to Drive Osteogenic Differentiation via YAP\/TAZ","volume":"7","author":"Wei","year":"2020","journal-title":"Adv Sci"},{"key":"10.1016\/j.jare.2022.08.019_b0280","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.24945","article-title":"Extracellular Ca2+ Promotes Odontoblastic Differentiation of Dental Pulp Stem Cells via BMP2-Mediated Smad1\/5\/8 and Erk1\/2 Pathways","author":"Li","year":"2015","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b0285","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.REV119.007963","article-title":"Control of cellular responses to mechanical cues through YAP\/TAZ regulation","author":"Dasgupta","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2022.08.019_b0290","doi-asserted-by":"crossref","DOI":"10.1038\/nrm.2017.87","article-title":"Mechanobiology of YAP and TAZ in physiology and disease","author":"Panciera","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jare.2022.08.019_b0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41536-021-00164-w","article-title":"Cyclic pulsation stress promotes bone formation of tissue engineered laminae through the F-actin\/YAP-1\/\u03b2-Catenin signaling axis","volume":"6","author":"Li","year":"2021","journal-title":"Npj Regen Med"},{"key":"10.1016\/j.jare.2022.08.019_b0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41526-020-00125-5","article-title":"Low-intensity vibration restores nuclear YAP levels and acute YAP nuclear shuttling in mesenchymal stem cells subjected to simulated microgravity","volume":"6","author":"Thompson","year":"2020","journal-title":"npj Microgravity"},{"key":"10.1016\/j.jare.2022.08.019_b0305","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-019-1499-2","article-title":"Force-induced conformational changes in PIEZO1","author":"Lin","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jare.2022.08.019_b0310","doi-asserted-by":"crossref","DOI":"10.1038\/nature25744","article-title":"Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel","author":"He","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jare.2022.08.019_b0315","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41413-021-00168-8","article-title":"Roles of mechanosensitive channel Piezo1\/2 proteins in skeleton and other tissues","volume":"9","author":"Qin","year":"2021","journal-title":"Bone Res"},{"key":"10.1016\/j.jare.2022.08.019_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibs.2021.01.008","article-title":"Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels","author":"Jiang","year":"2021","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.jare.2022.08.019_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.08.049","article-title":"Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels","author":"Douguet","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jare.2022.08.019_b0330","doi-asserted-by":"crossref","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","author":"Coste","year":"2010","journal-title":"Science (80-)"},{"key":"10.1016\/j.jare.2022.08.019_b0335","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/jbmr.4198","article-title":"Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation","volume":"36","author":"Hendrickx","year":"2021","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.49631","article-title":"Stimulation of piezo1 by mechanical signals promotes bone anabolism","volume":"8","author":"Li","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jare.2022.08.019_b0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-020-00124-y","article-title":"Piezo1 channel activation in response to mechanobiological acoustic radiation force in osteoblastic cells","volume":"9","author":"Zhang","year":"2021","journal-title":"Bone Res"},{"key":"10.1016\/j.jare.2022.08.019_b0350","article-title":"TMCO1-mediated Ca 2+ leak underlies osteoblast functions via CaMKII signaling","volume":"10","author":"Li","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2022.08.019_b0355","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-020-01657-z","article-title":"Comprehensive analysis of skeletal muscle- A nd bone-derived mesenchymal stem\/stromal cells in patients with osteoarthritis and femoral neck fracture","author":"\u010camernik","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jare.2022.08.019_b0360","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.15891","article-title":"Periosteum progenitors could stimulate bone regeneration in aged murine bone defect model","author":"Xiao","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jare.2022.08.019_b0365","doi-asserted-by":"crossref","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: Skeletal muscle as a secretory organ","author":"Pedersen","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jare.2022.08.019_b0370","doi-asserted-by":"crossref","DOI":"10.1038\/s41574-019-0174-x","article-title":"Physical activity and muscle\u2013brain crosstalk","author":"Pedersen","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jare.2022.08.019_b0375","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1002\/jbmr.1969","article-title":"Bone and skeletal muscle: Neighbors with close ties","volume":"28","author":"Digirolamo","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2015.02.010","article-title":"Bone and muscle: Interactions beyond mechanical","author":"Brotto","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.jare.2022.08.019_b0385","doi-asserted-by":"crossref","DOI":"10.3357\/AMHP.5097.2019","article-title":"Muscle activation during gravity-independent resistance exercise compared to common exercises","author":"Alkner","year":"2019","journal-title":"Aerosp Med Hum Perform"},{"key":"10.1016\/j.jare.2022.08.019_b0390","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2014716117","article-title":"Targeting myostatin\/activin A protects against skeletal muscle and bone loss during spaceflight","author":"Lee","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2022.08.019_b0395","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00592","article-title":"Structural and Functional Changes in the Coupling of Fascial Tissue, Skeletal Muscle, and Nerves During Aging","author":"Zullo","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b0400","article-title":"Regulation of Protein Synthesis in Inactivated Skeletal Muscle: Signal Inputs, Protein Kinase Cascades, and Ribosome Biogenesis","author":"Mirzoev","year":"2018","journal-title":"Biochem"},{"key":"10.1016\/j.jare.2022.08.019_b0405","doi-asserted-by":"crossref","DOI":"10.1152\/ajpregu.00292.2007","article-title":"Contractile and connective tissue protein content of human skeletal muscle: Effects of 35 and 90 days of simulated microgravity and exercise countermeasures","author":"Haus","year":"2007","journal-title":"Am J Physiol - Regul Integr Comp Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b0410","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(19)32910-1","article-title":"Muscular dystrophies","author":"Mercuri","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jare.2022.08.019_b0415","doi-asserted-by":"crossref","DOI":"10.1002\/jcsm.12470","article-title":"Muscle-specific changes in protein synthesis with aging and reloading after disuse atrophy","author":"Miller","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.jare.2022.08.019_b0420","article-title":"Increased adenine nucleotide degradation in skeletal muscle atrophy","author":"Miller","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2022.08.019_b0425","doi-asserted-by":"crossref","DOI":"10.1097\/WNR.0b013e32834f4048","article-title":"Disuse muscle atrophy exacerbates motor neuronal degeneration caudal to the site of spinal cord injury","author":"Ohnishi","year":"2012","journal-title":"NeuroReport"},{"key":"10.1016\/j.jare.2022.08.019_b0430","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13601","article-title":"Blood flow controls bone vascular function and osteogenesis","author":"Ramasamy","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2022.08.019_b0435","doi-asserted-by":"crossref","DOI":"10.3390\/cells10071749","article-title":"Vascularization strategies in bone tissue engineering","author":"Simunovic","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jare.2022.08.019_b0440","article-title":"3D bioprinting in orthopedics translational research","author":"Zheng","year":"2019","journal-title":"J Biomater Sci Polym Ed"},{"key":"10.1016\/j.jare.2022.08.019_b0445","doi-asserted-by":"crossref","DOI":"10.1177\/0022034518767120","article-title":"Vascularization in Craniofacial Bone Tissue Engineering","author":"Tian","year":"2018","journal-title":"J Dent Res"},{"key":"10.1016\/j.jare.2022.08.019_b0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2020.11.011","article-title":"Robotic in situ 3D bio-printing technology for repairing large segmental bone defects","author":"Li","year":"2021","journal-title":"J Adv Res"},{"key":"10.1016\/j.jare.2022.08.019_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2018.11.008","article-title":"Prefabrication of a large pedicled bone graft by engineering the germ for de novo vascularization and osteoinduction","author":"Epple","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jare.2022.08.019_b0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2019.10.002","article-title":"Hydroxyapatite\/silver electrospun fibers for anti-infection and osteoinduction","author":"Liu","year":"2020","journal-title":"J Adv Res"},{"key":"10.1016\/j.jare.2022.08.019_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in Signaling and Disease: Beyond Discovery and Development","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jare.2022.08.019_b0470","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.1958","article-title":"ATF4 promotes bone angiogenesis by increasing vegf expression and release in the bone environment","author":"Zhu","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0475","doi-asserted-by":"crossref","DOI":"10.1007\/s00223-018-0496-z","article-title":"Osteoblasts Regulate Angiogenesis in Response to Mechanical Unloading","author":"Veeriah","year":"2019","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jare.2022.08.019_b0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2013.03.040","article-title":"Osteogenic graft vascularization and bone resorption by VEGF-expressing human mesenchymal progenitors","author":"Helmrich","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jare.2022.08.019_b0485","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34323.019","article-title":"VEGF-C promotes the development of lymphatics in bone and bone loss","author":"Hominick","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.jare.2022.08.019_b0490","article-title":"VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism","author":"Zhang","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jare.2022.08.019_b0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.matbio.2016.02.005","article-title":"VEGF stimulates intramembranous bone formation during craniofacial skeletal development","author":"Duan","year":"2016","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jare.2022.08.019_b0500","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.26196","article-title":"Suppressing angiogenesis regulates the irradiation-induced stimulation on osteoclastogenesis in vitro","author":"Tong","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b0505","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc8479","article-title":"Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span","author":"Grunewald","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jare.2022.08.019_b0510","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/jbmr.3755","article-title":"VEGFA From Early Osteoblast Lineage Cells (Osterix+) Is Required in Mice for Fracture Healing","volume":"34","author":"Buettmann","year":"2019","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0515","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/jbmr.3610","article-title":"Chondrocytes Promote Vascularization in Fracture Healing Through a FOXO1-Dependent Mechanism","volume":"34","author":"Zhang","year":"2019","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0520","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/jbmr.2318","article-title":"SDF-1\/CXCR4 axis in tie2-Lineage cells including endothelial progenitor cells contributes to bone fracture healing","volume":"30","author":"Kawakami","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0525","doi-asserted-by":"crossref","DOI":"10.1007\/s00774-013-0538-6","article-title":"Synergistic and sequential effects of BMP-2, bFGF and VEGF on osteogenic differentiation of rat osteoblasts","author":"Li","year":"2014","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.jare.2022.08.019_b0530","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/03008207.2019.1669577","article-title":"Evidence of biglycan structure-function in bone homeostasis and aging","volume":"61","author":"Miguez","year":"2020","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.jare.2022.08.019_b0535","doi-asserted-by":"crossref","unstructured":"Hu L, Zang M de, Wang H xiao, Li J fang, Su L ping, Yan M, et al. Biglycan stimulates VEGF expression in endothelial cells by activating the TLR signaling pathway. Mol Oncol 2016;10:1473\u201384. https:\/\/doi.org\/10.1016\/j.molonc.2016.08.002.","DOI":"10.1016\/j.molonc.2016.08.002"},{"key":"10.1016\/j.jare.2022.08.019_b0540","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.matbio.2013.12.004","article-title":"Biglycan modulates angiogenesis and bone formation during fracture healing","volume":"35","author":"Berendsen","year":"2014","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jare.2022.08.019_b0545","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/jbmr.2786","article-title":"Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats","volume":"31","author":"Su","year":"2016","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0550","doi-asserted-by":"crossref","DOI":"10.1007\/s10439-009-9661-x","article-title":"Biomechanics: Cell research and applications for the next decade","author":"Discher","year":"2009","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.jare.2022.08.019_b0555","doi-asserted-by":"crossref","DOI":"10.1002\/jez.2340","article-title":"Defining biological stress and stress responses based on principles of physics","author":"K\u00fcltz","year":"2020","journal-title":"J Exp Zool Part A Ecol Integr Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2016.11.006","article-title":"Strain shielding in trabecular bone at the tibial cement-bone interface","author":"Srinivasan","year":"2017","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.jare.2022.08.019_b0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2008.07.013","article-title":"The Effect of Modular Tapered Fluted Stems on Proximal Stress Shielding in The Human Femur","author":"Hnat","year":"2009","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.jare.2022.08.019_b0570","doi-asserted-by":"crossref","DOI":"10.1002\/jor.24286","article-title":"Bone resorption triggered by high radial stress: The mechanism of screw loosening in plate fixation of long bone fractures","author":"Feng","year":"2019","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jare.2022.08.019_b0575","doi-asserted-by":"crossref","DOI":"10.1002\/jbm.820170304","article-title":"A new approach to the design of internal fixation plates","author":"Woo","year":"1983","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.jare.2022.08.019_b0580","article-title":"An experimental study on stress-shielding effects of locked compression plates in fixing intact dog femur","author":"Zhao","year":"2021","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.jare.2022.08.019_b0585","doi-asserted-by":"crossref","DOI":"10.1002\/jor.24072","article-title":"Multi-objective design optimization of high tibial osteotomy for improvement of biomechanical effect by using finite element analysis","author":"Koh","year":"2018","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jare.2022.08.019_b0590","doi-asserted-by":"crossref","DOI":"10.1097\/BOT.0b013e318207885b","article-title":"Biomechanics of far cortical locking","author":"Bottlang","year":"2011","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.jare.2022.08.019_b0595","doi-asserted-by":"crossref","DOI":"10.3238\/arztebl.2019.0757","article-title":"The Treatment of Proximal Humerus Fracture Using Internal Fixation With Fixed-angle Plates","author":"Ziegler","year":"2019","journal-title":"Dtsch Aerzteblatt Online"},{"key":"10.1016\/j.jare.2022.08.019_b0600","doi-asserted-by":"crossref","DOI":"10.1016\/S0020-1383(18)30295-X","article-title":"Evolution of plate design and material composition","author":"Hak","year":"2018","journal-title":"Injury"},{"key":"10.1016\/j.jare.2022.08.019_b0605","article-title":"Recent advances in bioprinting technologies for engineering different cartilage-based tissues","volume":"123","author":"Agarwal","year":"2021","journal-title":"Mater Sci Eng C"},{"key":"10.1016\/j.jare.2022.08.019_b0610","doi-asserted-by":"crossref","DOI":"10.1097\/00005131-199308000-00003","article-title":"Influences of some design parameters on the biomechanics of the unreamed tibial intramedullary nail","author":"Henley","year":"1993","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.jare.2022.08.019_b0615","doi-asserted-by":"crossref","DOI":"10.1097\/00005131-199710000-00006","article-title":"Effect of stainless steel and titanium low-Contact dynamic compression plate application on the vascularity and mechanical properties of cortical bone after fracture","author":"Jain","year":"1997","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.jare.2022.08.019_b0620","article-title":"Biomechanical properties of novel transpedicular transdiscal screw fixation with interbody arthrodesis technique in lumbar spine: A finite element study","author":"Lv","year":"2018","journal-title":"J Orthop Transl"},{"key":"10.1016\/j.jare.2022.08.019_b0625","article-title":"Re-fracture and correlated risk factors in patients with osteoporotic vertebral fractures","author":"Ma","year":"2019","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.jare.2022.08.019_b0630","doi-asserted-by":"crossref","DOI":"10.1001\/archinte.162.1.33","article-title":"Fractures between the ages of 20 and 50 years increase women\u2019s risk of subsequent fractures","author":"Wu","year":"2002","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jare.2022.08.019_b0635","article-title":"Correlation of Sagittal Imbalance and Recollapse after Percutaneous Vertebroplasty for Thoracolumbar Osteoporotic Vertebral Compression Fracture: A Multivariate Study of Risk Factors. Asian","author":"Kim","year":"2021","journal-title":"Spine J"},{"key":"10.1016\/j.jare.2022.08.019_b0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2015.10.026","article-title":"The positive correlation between upper adjacent vertebral fracture and the kyphosis angle of injured vertebral body after percutaneous kyphoplasty: An in vitro study","author":"Lu","year":"2015","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.jare.2022.08.019_b0645","doi-asserted-by":"crossref","DOI":"10.1016\/j.jos.2018.03.008","article-title":"The degeneration of adjacent intervertebral discs negatively influence union rate of osteoporotic vertebral fracture: A multicenter cohort study","author":"Rahmani","year":"2018","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.jare.2022.08.019_b0650","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-014-0485-1","article-title":"The role of peripheral nerve fibers and their neurotransmitters in cartilage and bone physiology and pathophysiology","author":"Gr\u00e4ssel","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jare.2022.08.019_b0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.matbio.2014.06.007","article-title":"Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification","author":"Niedermair","year":"2014","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jare.2022.08.019_b0660","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.61","article-title":"Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity","author":"Lee","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0665","doi-asserted-by":"crossref","DOI":"10.1002\/stem.2383","article-title":"Neuropeptide Y Induces Hematopoietic Stem\/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts","author":"Park","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.jare.2022.08.019_b0670","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jemt.10121","article-title":"Adrenergic regulation of bone metabolism: Possible involvement of sympathetic innervation of osteoblastic and osteoclastic cells","volume":"58","author":"Togari","year":"2002","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.jare.2022.08.019_b0675","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.2001.012575","article-title":"Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight","volume":"538","author":"Levine","year":"2002","journal-title":"J Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b0680","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1172\/JCI136105","article-title":"A GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress\u2013induced bone loss","volume":"130","author":"Yang","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2022.08.019_b0685","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2018.01.020","article-title":"Characterization of the bone marrow adipocyte niche with three-dimensional electron microscopy","author":"Robles","year":"2019","journal-title":"Bone"},{"key":"10.1016\/j.jare.2022.08.019_b0690","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2019.00668","article-title":"Shared autonomic pathways connect bone marrow and peripheral adipose tissues across the central neuraxis","author":"Wee","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jare.2022.08.019_b0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101522","article-title":"Neural regulation of bone marrow adipose tissue","volume":"35","author":"Zhang","year":"2021","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.jare.2022.08.019_b0700","doi-asserted-by":"crossref","DOI":"10.1210\/endo.142.8.8346","article-title":"Leptin Reduces Ovariectomy-Induced Bone Loss in Rats","author":"Burguera","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.jare.2022.08.019_b0705","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0092-8674(02)01049-8","article-title":"Leptin regulates bone formation via the sympathetic nervous system","volume":"111","author":"Takeda","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jare.2022.08.019_b0710","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20102608","article-title":"Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual","author":"Kajimura","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.jare.2022.08.019_b0715","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.21761","article-title":"Functional \u03b11- and \u03b22-adrenergic receptors in human osteoblasts","author":"Huang","year":"2009","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b0720","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2007.12.051","article-title":"Beta-2 adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms","author":"Aitken","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.jare.2022.08.019_b0725","article-title":"Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models","author":"Li","year":"2018","journal-title":"Neurosci Bull"},{"key":"10.1016\/j.jare.2022.08.019_b0730","doi-asserted-by":"crossref","DOI":"10.1136\/rapm-2021-102539","article-title":"Protein kinase G signaling pathway is involved in sympathetically maintained pain by modulating ATP-sensitive potassium channels","author":"Li","year":"2021","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.jare.2022.08.019_b0735","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21020405","article-title":"Impact of the sensory and sympathetic nervous system on fracture healing in ovariectomized mice","volume":"21","author":"Niedermair","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jare.2022.08.019_b0740","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2016.01.026","article-title":"Fracture pain-Traveling unknown pathways","author":"Alves","year":"2016","journal-title":"Bone"},{"key":"10.1016\/j.jare.2022.08.019_b0745","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115272","article-title":"An understanding of bone pain: A narrative review","author":"Oostinga","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.jare.2022.08.019_b0750","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2020.12.009","article-title":"Fibroblast growth factor 13 stabilizes microtubules to promote Na+ channel function in nociceptive DRG neurons and modulates inflammatory pain","author":"Wang","year":"2021","journal-title":"J Adv Res"},{"key":"10.1016\/j.jare.2022.08.019_b0755","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1172-7-S1-S3","article-title":"Pathophysiology and medical treatment of pain in fibrous dysplasia of bone","volume":"7","author":"Chapurlat","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jare.2022.08.019_b0760","doi-asserted-by":"crossref","unstructured":"Casta\u00f1eda-corral G, Jimenez-andrade JM, Bloom AP, Reid N, Mantyh WG, Kaczmarska MJ, et al. the Majority of Myelinated and Unmyelinated 2012:196\u2013207. https:\/\/doi.org\/10.1016\/j.neuroscience.2011.01.039.THE.","DOI":"10.1016\/j.neuroscience.2011.01.039"},{"key":"10.1016\/j.jare.2022.08.019_b0765","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/j.celrep.2016.08.002","article-title":"NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone","volume":"16","author":"Tomlinson","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.jare.2022.08.019_b0770","doi-asserted-by":"crossref","first-page":"E3632","DOI":"10.1073\/pnas.1701054114","article-title":"NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice","volume":"114","author":"Tomlinson","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2022.08.019_b0775","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2021.644929","article-title":"Piezo2 Knockdown Inhibits Noxious Mechanical Stimulation and NGF-Induced Sensitization in A-Delta Bone Afferent Neurons","volume":"12","author":"Nencini","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b0780","first-page":"1","article-title":"NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma","volume":"12","author":"Lee","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2022.08.019_b0785","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/jor.22892","article-title":"Analgesia via blockade of NGF\/TrkA signaling does not influence fracture healing in mice","volume":"33","author":"Rapp","year":"2015","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jare.2022.08.019_b0790","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/annrheumdis-2014-207203","article-title":"Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis","volume":"75","author":"Nwosu","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2022.08.019_b0795","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.115908","article-title":"The TrkA agonist gambogic amide augments skeletal adaptation to mechanical loading","volume":"147","author":"Fioravanti","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.jare.2022.08.019_b0800","doi-asserted-by":"crossref","DOI":"10.1038\/emboj.2010.126","article-title":"P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain","author":"Ulmann","year":"2010","journal-title":"EMBO J"},{"key":"10.1016\/j.jare.2022.08.019_b0805","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.clim.2006.01.016","article-title":"Prostaglandin E2 synthesis and secretion: The role of PGE2 synthases","volume":"119","author":"Park","year":"2006","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jare.2022.08.019_b0810","doi-asserted-by":"crossref","unstructured":"Pinto LG, Souza GR, Kusuda R, Lopes AH, Sant\u2019Anna MB, Cunha FQ, et al. Non-Peptidergic Nociceptive Neurons Are Essential for Mechanical Inflammatory Hypersensitivity in Mice. Mol Neurobiol 2019. https:\/\/doi.org\/10.1007\/s12035-019-1494-5.","DOI":"10.1007\/s12035-019-1494-5"},{"key":"10.1016\/j.jare.2022.08.019_b0815","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146442","article-title":"Enhancement of acid-sensing ion channel activity by prostaglandin E2 in rat dorsal root ganglion neurons","author":"Zhou","year":"2019","journal-title":"Brain Res"},{"key":"10.1016\/j.jare.2022.08.019_b0820","article-title":"Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis","volume":"10","author":"Chen","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2022.08.019_b0825","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1359\/jbmr.090412","article-title":"PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis","volume":"24","author":"Tsutsumi","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0830","doi-asserted-by":"crossref","DOI":"10.1016\/j.tem.2009.12.004","article-title":"Prostaglandins in bone: Bad cop, good cop?","author":"Blackwell","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jare.2022.08.019_b0835","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13476-9","article-title":"Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice","volume":"10","author":"Ni","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2022.08.019_b0840","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.115867","article-title":"Effects of treatment with a bone-targeted prostaglandin E2 receptor 4 agonist C3 (Mes-1007) in a mouse model of severe osteogenesis imperfecta","author":"Boraschi-Diaz","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.jare.2022.08.019_b0845","article-title":"TRPV1 Channel Activated by the PGE2\/EP4 Pathway Mediates Spinal Hypersensitivity in a Mouse Model of Vertebral Endplate Degeneration","author":"Liu","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jare.2022.08.019_b0850","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-021-00155-z","article-title":"PGE2\/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib","volume":"9","author":"Xue","year":"2021","journal-title":"Bone Res"},{"key":"10.1016\/j.jare.2022.08.019_b0855","article-title":"Effect of Single Versus Multiple Fractures on Systemic Bone Loss in Mice","author":"Zhang","year":"2021","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0860","doi-asserted-by":"crossref","DOI":"10.1002\/jor.25116","article-title":"Sex differences in systemic bone and muscle loss following femur fracture in mice","author":"Osipov","year":"2022","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jare.2022.08.019_b0865","doi-asserted-by":"crossref","DOI":"10.1002\/jor.22129","article-title":"Strongly enhanced levels of sclerostin during human fracture healing","author":"Sarahrudi","year":"2012","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jare.2022.08.019_b0870","doi-asserted-by":"crossref","DOI":"10.1210\/er.2011-1060","article-title":"Sclerostin and dickkopf-1 as therapeutic targets in bone diseases","author":"Ke","year":"2012","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jare.2022.08.019_b0875","doi-asserted-by":"crossref","DOI":"10.1007\/s12272-016-0810-0","article-title":"inhibits signal transduction of IL-6 and prevents ovariectomy-induced bone loss by suppressing osteoclastogenesis","author":"Kim","year":"2016","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.jare.2022.08.019_b0880","doi-asserted-by":"crossref","DOI":"10.1139\/cjpp-2019-0632","article-title":"Blockade of IL-6 alleviates bone loss induced by modelled microgravity in mice","author":"He","year":"2020","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jare.2022.08.019_b0885","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2021.151718","article-title":"IL-6 regulates the bone metabolism and inflammatory microenvironment in aging mice by inhibiting Setd7","author":"Wang","year":"2021","journal-title":"Acta Histochem"},{"key":"10.1016\/j.jare.2022.08.019_b0890","article-title":"Interleukin-6 Knockout Inhibits Senescence of Bone Mesenchymal Stem Cells in High-Fat Diet-Induced Bone Loss","author":"Li","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jare.2022.08.019_b0895","doi-asserted-by":"crossref","DOI":"10.3390\/nu10121930","article-title":"Calcium Intake in bone health: A focus on calcium-rich mineral waters","author":"Vannucci","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jare.2022.08.019_b0900","doi-asserted-by":"crossref","DOI":"10.22203\/eCM.v035a25","article-title":"Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover. Eur","author":"Fischer","year":"2018","journal-title":"Cells Mater"},{"key":"10.1016\/j.jare.2022.08.019_b0905","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-024595","article-title":"Comparison of fracture risk using different supplemental doses of Vitamin D, calcium or their combination: A network meta-analysis of randomised controlled trials","author":"Hu","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.jare.2022.08.019_b0910","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2012.164487","article-title":"Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: A randomized controlled trial","author":"McAlindon","year":"2013","journal-title":"JAMA - J Am Med Assoc"},{"key":"10.1016\/j.jare.2022.08.019_b0915","doi-asserted-by":"crossref","DOI":"10.1016\/j.maturitas.2014.07.005","article-title":"The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: A consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)","author":"Rizzoli","year":"2014","journal-title":"Maturitas"},{"key":"10.1016\/j.jare.2022.08.019_b0920","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2014.08.002","article-title":"Calcium and vitamin D supplementation maintains parathyroid hormone and improves bone density during initial military training: A randomized, double-blind, placebo controlled trial","author":"Gaffney-Stomberg","year":"2014","journal-title":"Bone"},{"key":"10.1016\/j.jare.2022.08.019_b0925","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2016.11.002","article-title":"Vitamin D and calcium supplementation for three years in postmenopausal osteoporosis significantly alters bone mineral and organic matrix quality","author":"Paschalis","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.jare.2022.08.019_b0930","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.2237","article-title":"The relationship between vitamin a and risk of fracture: Meta-analysis of prospective studies","author":"Wu","year":"2014","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b0935","article-title":"Vitamin K supplementation in postmenopausal women with osteopenia (ECKO Trial): A randomized controlled trial","author":"Cheung","year":"2008","journal-title":"PLoS Med"},{"key":"10.1016\/j.jare.2022.08.019_b0940","article-title":"Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model","author":"Zheng","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jare.2022.08.019_b0945","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2018.12.021","article-title":"Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging","author":"Hayashi","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.jare.2022.08.019_b0950","doi-asserted-by":"crossref","DOI":"10.1172\/JCI115588","article-title":"Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation","author":"Chow","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2022.08.019_b0955","doi-asserted-by":"crossref","DOI":"10.1007\/s11154-010-9137-1","article-title":"SERMs and SERMs with estrogen for postmenopausal osteoporosis","author":"Bolognese","year":"2010","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.jare.2022.08.019_b0960","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.00066.2017","article-title":"The activity of peptides of the calcitonin family in bone","author":"Naot","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jare.2022.08.019_b0965","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.00034.2013","article-title":"Calcitonin gene-related peptide: physiology and pathophysiology","author":"Russell","year":"2014","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jare.2022.08.019_b0970","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav9166","article-title":"ATRAID regulates the action of nitrogen-containing bisphosphonates on bone","author":"Surface","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jare.2022.08.019_b0975","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa0802633","article-title":"Giant Osteoclast Formation and Long-Term Oral Bisphosphonate Therapy","author":"Weinstein","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jare.2022.08.019_b0980","doi-asserted-by":"crossref","DOI":"10.1172\/JCI125915","article-title":"RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass","author":"Bonnet","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2022.08.019_b0985","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.03.010","article-title":"Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption","author":"McDonald","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jare.2022.08.019_b0990","article-title":"Biosimilar for teriparatide safe and effective","author":"Collison","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jare.2022.08.019_b0995","article-title":"316:7 (722\u2013733))","volume":"2017","author":"Erratum: Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: A randomized clinical trial (JAMA - Journal of the American Medical Association","year":"2016","journal-title":"JAMA - J Am Med Assoc"},{"key":"10.1016\/j.jare.2022.08.019_b1000","doi-asserted-by":"crossref","DOI":"10.1210\/er.2004-0006","article-title":"Parathyroid hormone and teriparatide for the treatment of osteoporosis: A review of the evidence and suggested guidelines for its use","author":"Hodsman","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jare.2022.08.019_b1005","doi-asserted-by":"crossref","DOI":"10.1007\/s00774-021-01235-0","article-title":"Long-term pretreatment with alendronate inhibits calvarial defect healing in an osteoporotic rat model","author":"Zhang","year":"2021","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.jare.2022.08.019_b1010","article-title":"Combination Therapy of PTH and Antiresorptive Drugs on Osteoporosis: A Review of Treatment Alternatives","author":"Zhang","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jare.2022.08.019_b1015","doi-asserted-by":"crossref","DOI":"10.1002\/jor.24953","article-title":"Once-weekly parathyroid hormone combined with ongoing long-term alendronate treatment promotes osteoporotic fracture healing in ovariectomized rats","author":"Zhang","year":"2021","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jare.2022.08.019_b1020","doi-asserted-by":"crossref","DOI":"10.5435\/00124635-200801000-00005","article-title":"Cast and splint immobilization: Complications","author":"Halanski","year":"2008","journal-title":"J Am Acad Orthop Surg"},{"key":"10.1016\/j.jare.2022.08.019_b1025","article-title":"Splints and casts: Indications and methods","author":"Boyd","year":"2009","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.jare.2022.08.019_b1030","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00198-019-05274-2","article-title":"Fracture risk following high-trauma versus low-trauma fracture: a registry-based cohort study","volume":"31","author":"Leslie","year":"2020","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jare.2022.08.019_b1035","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-019-1116-y","article-title":"An enhanced recovery after surgery program in orthopedic surgery: A systematic review and meta-analysis","author":"Hu","year":"2019","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.jare.2022.08.019_b1040","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2021.0586","article-title":"Opportunities and Challenges for the Next Phase of Enhanced Recovery after Surgery: A Review","author":"Ljungqvist","year":"2021","journal-title":"JAMA Surg"},{"key":"10.1016\/j.jare.2022.08.019_b1045","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1900544116","article-title":"BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle","author":"Delezie","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2022.08.019_b1050","doi-asserted-by":"crossref","DOI":"10.1113\/jphysiol.2010.200733","article-title":"Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression","author":"Pedersen","year":"2011","journal-title":"J Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b1055","doi-asserted-by":"crossref","DOI":"10.4161\/adip.20344","article-title":"Muscle-to-organ cross talk mediated by myokines","author":"Pedersen","year":"2012","journal-title":"Adipocyte"},{"key":"10.1016\/j.jare.2022.08.019_b1060","doi-asserted-by":"crossref","unstructured":"Tanaka K ichiro, Matsumoto E, Higashimaki Y, Sugimoto T, Seino S, Kaji H. FAM5C is a soluble osteoblast differentiation factor linking muscle to bone. Biochem Biophys Res Commun 2012. https:\/\/doi.org\/10.1016\/j.bbrc.2011.12.147.","DOI":"10.1016\/j.bbrc.2011.12.147"},{"key":"10.1016\/j.jare.2022.08.019_b1065","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021013118","article-title":"FGF-2\u2013dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis","author":"Mathes","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2022.08.019_b1070","doi-asserted-by":"crossref","DOI":"10.1038\/s41418-020-0508-1","article-title":"Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration","author":"Cong","year":"2020","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jare.2022.08.019_b1075","doi-asserted-by":"crossref","DOI":"10.1002\/j.2040-4603.2019.tb00062.x","article-title":"Insulin-like growth factor i regulation and its actions in skeletal muscle","author":"Vassilakos","year":"2019","journal-title":"Compr Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b1080","doi-asserted-by":"crossref","DOI":"10.1046\/j.1468-1331.2003.00481.x","article-title":"Eosinophilic major basic protein and interleukin-5 in eosinophilic myositis","author":"Murata","year":"2003","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.jare.2022.08.019_b1085","doi-asserted-by":"crossref","DOI":"10.1172\/JCI133572","article-title":"Muscle-derived interleukin 6 increases exercise capacity by signaling in osteoblasts","author":"Chowdhury","year":"2020","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2022.08.019_b1090","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.00094.2009","article-title":"IL-7 is expressed and secreted by human skeletal muscle cells","author":"Haugen","year":"2010","journal-title":"Am J Physiol - Cell Physiol"},{"key":"10.1016\/j.jare.2022.08.019_b1095","doi-asserted-by":"crossref","DOI":"10.1172\/JCI44945","article-title":"Loss of IL-15 receptor \u03b1 alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles","author":"Pistilli","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2022.08.019_b1100","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01131-0","article-title":"Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy","author":"Reza","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2022.08.019_b1105","article-title":"Leukaemia inhibitory factor - An exercise-induced myokine","author":"Broholm","year":"2010","journal-title":"Exerc Immunol Rev"},{"key":"10.1016\/j.jare.2022.08.019_b1110","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143737","article-title":"IRE1\u03b1 regulates skeletal muscle regeneration through myostatin mRNA decay","author":"He","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2022.08.019_b1115","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.139.3.709","article-title":"Neurotrophin-3-enhanced nerve regeneration selectively improves recovery of muscle fibers expressing myosin heavy chains 2b","author":"Sterne","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jare.2022.08.019_b1120","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1705420114","article-title":"Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration & strength","author":"Ho","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2022.08.019_b1125","doi-asserted-by":"crossref","DOI":"10.1096\/fj.13-228528","article-title":"TGF\u03b21 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of Rho-kinase-2 activation","author":"Cencetti","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.jare.2022.08.019_b1130","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.226","article-title":"The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa c-terminal fragment","author":"Lu","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b1135","doi-asserted-by":"crossref","DOI":"10.1136\/ard.2010.132852","article-title":"Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression","author":"Heiland","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jare.2022.08.019_b1140","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.478","article-title":"FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone","author":"W\u00f6hrle","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b1145","doi-asserted-by":"crossref","DOI":"10.1517\/14728222.2016.1162293","article-title":"Hepatocyte growth factor and alternative splice variants - expression, regulation and implications in osteogenesis and bone health and repair","author":"Frisch","year":"2016","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.jare.2022.08.019_b1150","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1607235113","article-title":"Gut microbiota induce IGF-1 and promote bone formation and growth","author":"Yan","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jare.2022.08.019_b1155","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.345","article-title":"Sclerostin is a locally acting regulator of late-osteoblast\/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism","author":"Atkins","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b1160","doi-asserted-by":"crossref","DOI":"10.1080\/19336918.2019.1686103","article-title":"Splicing factor-modulated generation of mechano growth factor regulates physiological processes in osteoblasts under mechanical stimuli","author":"Yi","year":"2019","journal-title":"Cell Adhes Migr"},{"key":"10.1016\/j.jare.2022.08.019_b1165","doi-asserted-by":"crossref","DOI":"10.1080\/08923970600816723","article-title":"Effect of Buthus martensi Karsch on aromatase activity and cytokine-inducded NOS and NO production in osteoblasts and leukaemic cell line FLG 29.1","author":"Jin","year":"2006","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.jare.2022.08.019_b1170","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-018-0019-6","article-title":"Paracrine and endocrine actions of bone - The functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts","author":"Han","year":"2018","journal-title":"Bone Res"},{"key":"10.1016\/j.jare.2022.08.019_b1175","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-020-00106-0","article-title":"BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl\/Opg expression ratio in osteoblasts","author":"Yahiro","year":"2020","journal-title":"Bone Res"},{"key":"10.1016\/j.jare.2022.08.019_b1180","article-title":"Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis","author":"Chen","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jare.2022.08.019_b1185","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-018-0040-9","article-title":"RANKL-RANK signaling regulates osteoblast differentiation and bone formation","author":"Cao","year":"2018","journal-title":"Bone Res"},{"key":"10.1016\/j.jare.2022.08.019_b1190","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.2342","article-title":"Methylation of bone SOST, its mRNA, and serum sclerostin levels correlate strongly with fracture risk in postmenopausal women","author":"Reppe","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jare.2022.08.019_b1195","doi-asserted-by":"crossref","DOI":"10.1016\/j.tips.2014.03.005","article-title":"Targeting TGF\u03b2 signaling in subchondral bone and articular cartilage homeostasis","author":"Zhen","year":"2014","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.jare.2022.08.019_b1200","doi-asserted-by":"crossref","DOI":"10.1172\/JCI82585","article-title":"Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair","author":"Hu","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jare.2022.08.019_b1205","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2007-10-120253","article-title":"Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth","author":"Qiang","year":"2008","journal-title":"Blood"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123222002004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123222002004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T20:56:21Z","timestamp":1761857781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123222002004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":241,"alternative-id":["S2090123222002004"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2022.08.019","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathophysiological mechanism of acute bone loss after fracture","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2022.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}